Lung Function Changes and Exercise-Induced Ventilatory Responses to External Resistive Loads in Normal Subjects

Respiration ◽  
1995 ◽  
Vol 62 (4) ◽  
pp. 177-184 ◽  
Author(s):  
Klaus Wassermann ◽  
Anselm Gitt ◽  
Joanna Weyde ◽  
Hans Edmund Eckel
Keyword(s):  
Lung Function ◽  
Normal Subjects ◽  
Ventilatory Responses ◽  
Resistive Loads ◽  
Exercise Induced

Effect of ethanol and naloxone on control of ventilation and load perception

1983 ◽  
Vol 55 (3) ◽  
pp. 929-934 ◽  
Author(s):  
T. M. Michiels ◽  
R. W. Light ◽  
C. K. Mahutte
Keyword(s):  
Normal Subjects ◽  
Ethanol Ingestion ◽  
Resistive Load ◽  
Load Compensation ◽  
Ventilatory Responses ◽  
Resistive Loading ◽  
Resistive Loads ◽  
Mouth Occlusion Pressure ◽  
Load Perception ◽  
Respiratory Depressant

The respiratory depressant effects of ethanol and their potential reversibility by naloxone were studied in 10 normal subjects. Ventilatory and mouth occlusion pressure (P0.1) responses to hypercapnia and hypoxia without and with an inspiratory resistive load (13 cmH2O X 1(-1) X S) were measured. The resistive load detected with 50% probability (delta R50) and the exponent (n) in Stevens' psychophysical law for magnitude estimation of resistive loads were studied using standard psychophysical techniques. Each of these studies was performed before ethanol ingestion, after ethanol ingestion (1.5 ml/kg, by mouth), and then again after naloxone (0.8 mg iv). Ethanol increased delta R50 (P less than 0.05) and decreased n (P less than 0.05). Naloxone caused no further change in these parameters. The load compensation (Lc), defined as the ratio of loaded to unloaded response slopes, was not significantly changed after ethanol and naloxone. No correlation was found between the Lc and delta R50 or n. The ventilatory and P0.1 responses to hypercapnia and hypoxia with and without inspiratory resistive loading decreased after ethanol (P less than 0.05, hypercapnia; NS, hypoxia). After naloxone the hypercapnic ventilatory responses increased (P less than 0.05). This suggests that the respiratory depressant effects of ethanol may be mediated via endorphins.

Is low-level respiratory resistive loading during exercise perceived as breathlessness?

1987 ◽  
Vol 73 (6) ◽  
pp. 627-634 ◽  
Author(s):  
R. Lane ◽  
L. Adams ◽  
A. Guz
Keyword(s):  
Loading Condition ◽  
Work Of Breathing ◽  
Respiratory Muscles ◽  
Normal Subjects ◽  
Low Level ◽  
Resistive Loading ◽  
The Subject ◽  
Resistive Loads ◽  
Exercise Induced ◽  
Subjective Estimates

1. The effect of adding low-level (2.7 cmH2O 1−1 s) external respiratory resistive loads on exercise-induced breathlessness has been examined in naive normal subjects; the intensity of this loading was chosen to simulate that confronting an asthmatic subject during exercise. 2. Each of 18 subjects performed two separate tests in which workload was oscillated while the respiratory loading was changed every minute between no loading, inspiratory loading only, and inspiratory plus expiratory loading. Each loading condition was given three times, and both these changes and those in workload were unpredictable as far as the subject was concerned. 3. The purpose was to ‘confuse’ subjects and obtain subjective estimates of their intensity of breathlessness independent of any expectation associated solely with the readily perceptible changes in external resistances to breathing. The study design was balanced for the group as a whole, both in terms of workload and respiratory loading condition. 4. The addition of these respiratory resistive loads during exercise did not result in a significant increase in the intensity of breathlessness. 5. Estimates of the rate of work of breathing revealed that this increased more with respiratory loading than it did as ventilation rose throughout the test; on the other hand, the intensity of breathlessness increased by a greater extent with continued exercise compared with the changes accompanying the addition of respiratory loads. 6. It is concluded that the intensity of the sensation of breathlessness experienced by normal subjects during exercise is not simply a reflection of an increased rate of work of breathing being performed by the respiratory muscles. 7. It is further suggested that similar studies in which internal resistances are increased experimentally are indicated in order to analyse the factors underlying the breathlessness of asthma.

Analysis of the exercise-induced orthogonal P wave changes in normal subjects and patients with coronary artery disease.

1986 ◽  
Vol 27 (4) ◽  
pp. 443-460 ◽  
Author(s):  
Mitsuhiro YOKOTA ◽  
Shoji NODA ◽  
Masafumi KOIDE ◽  
Naoki KAWAI ◽  
Reiki YOSHIDA ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Normal Subjects ◽  
P Wave ◽  
Artery Disease ◽  
Exercise Induced

Detection Latency of Added Loads to Breathing

1982 ◽  
Vol 63 (1) ◽  
pp. 11-15 ◽  
Author(s):  
J. G. W. Burdon ◽  
K. J. Killian ◽  
E. J. M. Campbell
Keyword(s):  
Peak Inspiratory Pressure ◽  
Normal Subjects ◽  
Reciprocal Relationship ◽  
Respiratory Cycle ◽  
Curvilinear Relationship ◽  
Similar Relationship ◽  
Detection Latency ◽  
Mechanical Information ◽  
Resistive Loads ◽  
Comparable Magnitude

1. Detection latency of a range of added elastic (0·95–4·50 kPa/l) and resistive (0·73–3·29 kPa l−1 s) loads to breathing were measured in five normal subjects. Detection latency was defined as the time from the onset of the breath to detection of the load. 2. Detection latency followed a curvilinear relationship when plotted as a function of the magnitude of the added loads. A similar relationship was found with both elastic and resistive loads although detection latencies to added elastances were longer than for added resistances. 3. When the added load was expressed in terms of comparable magnitude (peak inspiratory pressure) detection latencies for added elastances were found to be consistently longer than for added resistive loads. 4. These studies show that the detection latency to added inspiratory loads follows a reciprocal relationship, that detection latencies for elastic and resistive loads are clearly different and suggest that these loads are detected during the respiratory cycle at a time when the mechanical information regarding muscular pressure is greatest.

Effects of expiratory loading on respiration in humans

1980 ◽  
Vol 49 (4) ◽  
pp. 601-608 ◽  
Author(s):  
B. Gothe ◽  
N. S. Cherniack
Keyword(s):  
Muscle Activity ◽  
Healthy Subjects ◽  
Respiratory Muscle ◽  
Resistive Load ◽  
Similar Magnitude ◽  
Occlusion Pressure ◽  
Ventilatory Responses ◽  
Residual Capacity ◽  
Resistive Loads ◽  
The Difference

We examined the effects of expiratory resistive loads of 10 and 18 cmH2O.l-1.s in healthy subjects on ventilation and occlusion pressure responses to CO2, respiratory muscle electromyogram, pattern of breathing, and thoracoabdominal movements. In addition, we compared ventilation and occlusion pressure responses to CO2 breathing elicited by breathing through an inspiratory resistive load of 10 cmH2O.l-1.s to those produced by an expiratory load of similar magnitude. Both inspiratory and expiratory loads decreased ventilatory responses to CO2 and increased the tidal volume achieved at any given level of ventilation. Depression of ventilatory responses to Co2 was greater with the larger than with the smaller expiratory load, but the decrease was in proportion to the difference in the severity of the loads. Occlusion pressure responses were increased significantly by the inspiratory resistive load but not by the smaller expiratory load. However, occlusion pressure responses to CO2 were significantly larger with the greater expiratory load than control. Increase in occlusion pressure observed could not be explained by changes in functional residual capacity or chemical drive. The larger expiratory load also produced significant increases in electrical activity measured during both inspiration and expiration. These results suggest that sufficiently severe impediments to breathing, even when they are exclusively expiratory, can enhance inspiratory muscle activity in conscious humans.

Ventilatory and occlusion pressure responses to helium breathing

1983 ◽  
Vol 54 (6) ◽  
pp. 1525-1531 ◽  
Author(s):  
E. L. DeWeese ◽  
T. Y. Sullivan ◽  
P. L. Yu
Keyword(s):  
Breathing Circuit ◽  
Minute Ventilation ◽  
Normal Subjects ◽  
Mouth Pressure ◽  
Partial Pressure Of Co2 ◽  
Lung Resistance ◽  
Balloon Technique ◽  
Resistive Loads ◽  
End Tidal ◽  
Airway Tone

To characterize the ventilatory response to resistive unloading, we studied the effect of breathing 79.1% helium-20.9% oxygen (He-O2) on ventilation and on mouth pressure measured during the first 100 ms of an occluded inspiration (P100) in normal subjects at rest. The breathing circuit was designed so that external resistive loads during both He-O2 and air breathing were similar. Lung resistance, measured in three subjects with an esophageal balloon technique, was reduced by 23 +/- 8% when breathing He-O2. Minute ventilation, tidal volume, respiratory frequency, end-tidal partial pressure of CO2, inspiratory and expiratory durations, and mean inspiratory flow were not significantly different when air was replaced by He-O2. P100, however, was significantly less during He-O2 breathing. We conclude that internal resistive unloading by He-O2 breathing reduces the neuromuscular output required to maintain constant ventilation. Unlike studies involving inhaled bronchodilators, this technique affords a method by which unloading can be examined independent of changes in airway tone.

scholarly journals The effect of posture on ventilatory muscle function and lung function

1986 ◽  
Vol 42 (3) ◽  
pp. 81-84 ◽  
Author(s):  
P. Gounden
Keyword(s):  
Muscle Strength ◽  
Lung Function ◽  
Muscle Function ◽  
Normal Subjects ◽  
Normal Group ◽  
Optimum Position ◽  
Asthmatic Group

The purpose of this study was to determine the influence of posture on ventilatory muscle strength and on lung function.Maximum static inspiratory pressures (MIPS), maximum static expiratory pressures (MEPS) and lung function measurements (FVC, FEV1, PEFR) were obtained in three different body positions in 57 normal subjects and in 16 asthmatic patients.Statistical analysis of the data obtained showed that changes in position influence the ventilatory muscle function and lung function values.The sitting lean forward and the sitting erect positions were the better positions in the normal group. The findings revealed that the sitting lean forward position was the optimum position for the asthmatic group (p 0,001).

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