Effects of GLP-1 on Gastric Acid and Pancreatic Exocrine Secretion and on Gastrointestinal Motility

1997 ◽  
pp. 194-206
Author(s):  
Michael A. Nauck ◽  
Wolfgang Schepp ◽  
Jens J. Holst ◽  
Wolff H. Schmiegel
Keyword(s):  
Gastric Acid ◽  
Gastrointestinal Motility ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine

Structural requirements of peptide YY for biological activity at enteric sites

1992 ◽  
Vol 263 (5) ◽  
pp. G695-G701 ◽  
Author(s):  
K. Yoshinaga ◽  
T. Mochizuki ◽  
N. Yanaihara ◽  
K. Oshima ◽  
M. Izukura ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Insulin Release ◽  
Peptide Yy ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Structural Requirements ◽  
Pancreatic Exocrine

Peptide YY (PYY) is a colonic hormone consisting of 36 amino acids that is a potent inhibitor of pancreatic exocrine, gastric acid, and insulin secretion. The objective of the present experiments was to characterize the structural requirements of PYY for inhibition of pancreatic exocrine, gastric acid, and insulin secretion, using conscious dogs prepared with gastric and pancreatic fistulas. Intravenous administration of PYY-(1-36), PYY-(3-36), or PYY-(4-36) (400 pmol.kg-1 x h-1) inhibited cholecystokinin-8-stimulated (25 pmol.kg-1 x h-1) pancreatic exocrine secretion (P < 0.05); however, PYY-(1-10), PYY-(1-20), PYY-(6-36), PYY-(10-36), PYY-(13-36), PYY-(24-36), and PYY-(27-36) did not inhibit pancreatic exocrine secretion. Intravenous administration of PYY-(1-36), PYY-(3-36), or PYY-(4-36) (200, 400, 800 pmol.kg-1 x h-1) inhibited pentagastrin (0.5 microgram.kg-1 x h-1)-stimulated gastric acid secretion (P < 0.05), as well as 2-deoxy-D-glucose-stimulated insulin release (75 mg/kg) in a dose-related manner. PYY-(6-36), PYY-(13-36), and [Leu31, Pro34] neuropeptide Y did not inhibit either gastric acid secretion or insulin release. In the gastric acid and insulin secretion bioassays, PYY-(1-36) was significantly more potent than PYY-(3-36) and PYY-(4-36); however, in the pancreatic exocrine secretion bioassay, the inhibitory effects of PYY-(3-36) and PYY-(1-36) did not differ significantly. PYY-(4-36) was less potent than PYY-(1-36) on pancreatic exocrine secretion.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs

1986 ◽  
Vol 250 (1) ◽  
pp. G127-G133
Author(s):  
T. Pappas ◽  
H. T. Debas ◽  
J. H. Walsh ◽  
J. Rivier ◽  
Y. Tache
Keyword(s):  
Gastric Emptying ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Calcitonin Gene Related Peptide ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Pancreatic Exocrine

Calcitonin gene-related peptide (CGRP) is a 37-residue peptide recently characterized in the brain and found in high concentrations in the gut, particularly in the stomach and pancreas. The effects of intravenous infusion of human and rat CGRP (260 pmol . kg-1 . h-1) on gastric secretion and emptying and pancreatic exocrine secretion were studied in conscious dogs. CGRP inhibited by 60-75% gastric acid secretion stimulated by a meal, sham feeding, or step doses of bombesin but did not modify acid response to step doses of histamine or bethanechol. The inhibitory effect of CGRP is not due to blockage of postprandial or bombesin-stimulated gastrin release. CGRP did not influence basal or meal-stimulated pancreatic exocrine secretion or the rate of gastric emptying of a saline meal. These results indicate that CGRP is a potent and selective inhibitor of gastrin-mediated acid secretion in dogs and, under these conditions, did not alter other gastrointestinal functions such as gastric emptying or pancreatic exocrine secretion.

The effect of AFMK (N 1 -acetyl-N 2 -formyl-5-methoxykynuramine) on pancreatic exocrine secretion in the rats

Pancreatology ◽  
2017 ◽  
Vol 17 (3) ◽  
pp. S28
Author(s):  
Katarzyna Nawrot-Porabka ◽  
Anna Leja-Szpak ◽  
Joanna Szklarczyk ◽  
Joanna Bonior ◽  
Marta Góralska ◽  
...  
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine

Effect of Ethanol Intake on Pancreatic Exocrine Secretion in Mice

1992 ◽  
Vol 27 (9) ◽  
pp. 783-786 ◽  
Author(s):  
M. I. Vaccaro ◽  
O. M. Tiscornia ◽  
E. L. Calvo ◽  
M. A. Cresta ◽  
D. Celener
Keyword(s):  
Exocrine Secretion ◽  
Ethanol Intake ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine

Sow milk feeding vs. pancreatic exocrine secretion in pigs

1997 ◽  
Vol 50 (1-2) ◽  
pp. 151-152 ◽  
Author(s):  
S.G. Pierzynowski ◽  
B.R. Weström ◽  
B.W. Karlsson
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine ◽  
Milk Feeding

Feedback Regulation of Pancreatic Exocrine Secretion in Minipigs

1997 ◽  
Vol 32 (4) ◽  
pp. 374-379 ◽  
Author(s):  
T. Houe ◽  
S. S. Sætre ◽  
P. Svendsen ◽  
O. Olsen ◽  
J. F. Rehfeld ◽  
...  
Keyword(s):  
Feedback Regulation ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Pancreatic Exocrine

Vagally mediated, nonparacrine effects of cholecystokinin-8s on rat pancreatic exocrine secretion

2007 ◽  
Vol 293 (2) ◽  
pp. G493-G500 ◽  
Author(s):  
Eddy Viard ◽  
Zhongling Zheng ◽  
Shuxia Wan ◽  
R. Alberto Travagli
Keyword(s):  
Brain Stem ◽  
Protein Secretion ◽  
Exocrine Secretion ◽  
Vagal Afferents ◽  
Dependent Manner ◽  
Pancreatic Exocrine Secretion ◽  
Sprague Dawley ◽  
Pancreatic Exocrine ◽  
Vagal Afferent

Cholecystokinin (CCK) has been proposed to act in a vagally dependent manner to increase pancreatic exocrine secretion via actions exclusively at peripheral vagal afferent fibers. Recent evidence, however, suggests the CCK-8s may also affect brain stem structures directly. We used an in vivo preparation with the aims of 1) investigating whether the actions of intraduodenal casein perfusion to increase pancreatic protein secretion also involved direct actions of CCK at the level of the brain stem and, if so, 2) determining whether, in the absence of vagal afferent inputs, CCK-8s applied to the dorsal vagal complex (DVC) can also modulate pancreatic exocrine secretion (PES). Sprague-Dawley rats (250–400 g) were anesthetized and the common bile-pancreatic duct was cannulated to collect PES. Both vagal deafferentation and pretreatment with the CCK-A antagonist lorglumide on the floor of the fourth ventricle decreased the casein-induced increase in PES output. CCK-8s microinjection (450 pmol) in the DVC significantly increased PES; the increase was larger when CCK-8s was injected in the left side of the DVC. Protein secretion returned to baseline levels within 30 min. Microinjection of CCK-8s increased PES (although to a lower extent) also in rats that underwent complete vagal deafferentation. These data indicate that, as well as activating peripheral vagal afferents, CCK-8s increases pancreatic exocrine secretion via an action in the DVC. Our data suggest that the CCK-8s-induced increases in PES are due mainly to a paracrine effect of CCK; however, a relevant portion of the effects of CCK is due also to an effect of the peptide on brain stem vagal circuits.

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