Surface Adsorption of Pulmonary Surfactant in Relation to Bulk-Phase Concentration and Presence of CaCl2

Respiration ◽  
1983 ◽  
Vol 44 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Tsutomu Kobayashi ◽  
Bengt Robertson
Keyword(s):  
Pulmonary Surfactant ◽  
Surface Adsorption ◽  
Bulk Phase ◽  
Phase Concentration

Dextran restores albumin-inhibited surface activity of pulmonary surfactant extract

1999 ◽  
Vol 86 (6) ◽  
pp. 1778-1784 ◽  
Author(s):  
Tsutomu Kobayashi ◽  
Keisuke Ohta ◽  
Katsumi Tashiro ◽  
Kazuo Nishizuka ◽  
Wei-Min Chen ◽  
...  
Keyword(s):  
Surface Activity ◽  
Pulmonary Surfactant ◽  
Inhibitory Action ◽  
Surface Adsorption ◽  
Underlying Mechanism ◽  
Surfactant Proteins ◽  
Plasma Albumin ◽  
Adsorption Time ◽  
Natural Surfactant ◽  
Minimum Surface Tension

We examined the effect of dextran (molecular weight 71,000) in counteracting the surfactant inhibitory action of plasma albumin. The surface adsorption time of 0.5 mg/ml modified natural surfactant (MNS; porcine lung extract consisting of phospholipids and hydrophobic surfactant proteins) with 7.5 mg/ml albumin decreased from 681 to 143 s by addition of dextran at a concentration of 10 mg/ml ( P < 0.01). The minimum surface tension of 2.0 mg/ml MNS with 30 mg/ml albumin decreased from over 21 mN/m to below 3 mN/m when dextran was added at a concentration of 10 mg/ml ( P < 0.01). Surfactant-deficient newborn rabbits given 10 ml/kg of a liquid containing 2.0 mg/ml MNS with 30 mg/ml albumin had a mean tidal volume ≤5 ml/kg after 5 min of mechanical ventilation, but, in those animals given the liquid containing 10 mg/ml dextran also, the volume was >13 ml/kg ( P < 0.05). Although the underlying mechanism remains to be elucidated, we conclude that dextran restores the albumin-inhibited surface activity of MNS.

Thermal Stability and DPPC/Ca2+Interactions of Pulmonary Surfactant SP-A from Bulk-Phase and Monolayer IR Spectroscopy†

Biochemistry ◽  
2001 ◽  
Vol 40 (45) ◽  
pp. 13659-13669 ◽  
Author(s):  
Xiaohong Bi ◽  
Svetla Taneva ◽  
Kevin M. W. Keough ◽  
Richard Mendelsohn ◽  
Carol R. Flach
Keyword(s):  
Thermal Stability ◽  
Ir Spectroscopy ◽  
Pulmonary Surfactant ◽  
Bulk Phase

Pulmonary surfactant given prophylactically alleviates an asthma attack in guinea-pigs

1996 ◽  
Vol 26 (3) ◽  
pp. 270-275 ◽  
Author(s):  
M. LIU ◽  
L. WANG ◽  
E. LI ◽  
G. ENHORNING
Keyword(s):  
Guinea Pigs ◽  
Pulmonary Surfactant ◽  
Asthma Attack

Pb Electrodeposition in the Presence of Chlorine Ions on Cu(100): An in Situ Optical Reflectivity Difference Study

2003 ◽  
Vol 781 ◽  
Author(s):  
J. Gray ◽  
W. Schwarzacher ◽  
X.D. Zhu
Keyword(s):  
Oblique Incidence ◽  
Opposite Sign ◽  
Bulk Phase ◽  
Phase Layer ◽  
Optical Reflectivity ◽  
Scan Rate ◽  
Different Types ◽  
Chlorine Ions ◽  
High Overpotentials

AbstractWe studied the initial stages of the electrodeposition of Pb in the presence of chlorine ions on Cu(100), using an oblique-incidence optical reflectivity difference (OIRD) technique. The OI-RD results reveal that immediately following the underpotential deposition (UPD) of the first Pb monolayer, two different types of bulk-phase films grow depending upon the magnitude of overpotential and cyclic voltammetry (CV) scan rate. At low overpotentials and/or slow scan rates, we propose that a bulk-phase Pb film grows on top of the UPD monolayer. At high overpotentials and/or fast scan rates, either a PbO, PbCl2, or a rough Pb bulk-phase layer grows on top of the UPD layer such that the reflectivity difference signal from such a film has an opposite sign.

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