Comparison of Single Breath and Steady State Methods for the Measurement of Pulmonary Diffusing Capacity for Carbon Monoxide in Non-Homogeneous Lungs

Respiration ◽  
1978 ◽  
Vol 36 (3) ◽  
pp. 117-126 ◽  
Author(s):  
J.N. Pande ◽  
J.S. Guleria
Keyword(s):  
Carbon Monoxide ◽  
Steady State ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity ◽  
Single Breath

Effect of exercise on pulmonary diffusing capacity

1963 ◽  
Vol 18 (3) ◽  
pp. 447-456 ◽  
Author(s):  
G. M. Turino ◽  
E. H. Bergofsky ◽  
R. M. Goldring ◽  
A. P. Fishman
Keyword(s):  
Carbon Monoxide ◽  
Young Adults ◽  
Steady State ◽  
Body Position ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity ◽  
Graded Exercise ◽  
Normal Man ◽  
The Difference

The effect of graded exercise on the pulmonary diffusing capacity for both oxygen and carbon monoxide measured simultaneously was studied in healthy young adults by steady-state methods. Pulmonary diffusing capacity for oxygen increases progressively with increasing severity of exercise; it exceeds the DlCO at high levels of exercise by amounts greater than can be accounted for by the difference in diffusivity of the test gases. Diffusing capacity for carbon monoxide increases less than DlOO2 for comparable grades of exercise but no definite plateau value could be established. The supine or upright body position does not influence the values of either DlOO2 or DlCO during exercise. Diffusing capacity of the lung for oxygen does not limit the maximum levels of exercise which may be achieved by normal man. Submitted on August 6, 1962

Carbon Monoxide Diffusing Capacity of the Lungs Determined by Single-Breath and Steady-State Exercise Methods

1989 ◽  
Vol 64 (1) ◽  
pp. 51-59 ◽  
Author(s):  
KENNETH C. BECK ◽  
ROBERT E. HYATT ◽  
BRUCE A. STAATS ◽  
PAUL L. ENRIGHT ◽  
JOSEPH R. RODARTE
Keyword(s):  
Carbon Monoxide ◽  
Steady State ◽  
Diffusing Capacity ◽  
Single Breath

Effect of Body Temperature on Pulmonary Gas Exchange

1957 ◽  
Vol 188 (2) ◽  
pp. 355-359 ◽  
Author(s):  
A. B. Otis ◽  
James Jude
Keyword(s):  
Carbon Dioxide ◽  
Carbon Monoxide ◽  
Steady State ◽  
Body Temperature ◽  
Gas Exchange ◽  
Diffusing Capacity ◽  
Body Temperatures ◽  
Pulmonary Diffusing Capacity ◽  
Normal Body ◽  
Anesthetized Dogs

Measurements were made of the arterial-alveolar carbon dioxide gradient in anesthetized dogs at body temperatures ranging from normal down to 16°C. Pulmonary diffusing capacity was determined by a steady-state carbon monoxide method in anesthetized dogs at normal body temperatures and at 25°C. From the results it is concluded that although diffusing capacity is reduced at low body temperatures, it is still adequate for transfer of both CO2 and O2 because the metabolic requirements for gas exchange are also reduced.

scholarly journals An Assessment of the Steady-state Carbon Monoxide Method of Estimating Pulmonary Diffusing Capacity

Thorax ◽  
1959 ◽  
Vol 14 (2) ◽  
pp. 166-175 ◽  
Author(s):  
J. MacNamara ◽  
F. J. Prime ◽  
J. D. Sinclair
Keyword(s):  
Carbon Monoxide ◽  
Steady State ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity

The effect of conductive ventilation heterogeneity on diffusing capacity measurement

2008 ◽  
Vol 104 (4) ◽  
pp. 1094-1100 ◽  
Author(s):  
Sylvia Verbanck ◽  
Daniel Schuermans ◽  
Sophie Van Malderen ◽  
Walter Vincken ◽  
Bruce Thompson
Keyword(s):  
Carbon Monoxide ◽  
Vital Capacity ◽  
Experimental Situation ◽  
Normal Subjects ◽  
Diffusing Capacity ◽  
Capacity Measurement ◽  
Alveolar Volume ◽  
Estimation Errors ◽  
Single Breath ◽  
Ventilation Heterogeneity

It has long been assumed that the ventilation heterogeneity associated with lung disease could, in itself, affect the measurement of carbon monoxide transfer factor. The aim of this study was to investigate the potential estimation errors of carbon monoxide diffusing capacity (DlCO) measurement that are specifically due to conductive ventilation heterogeneity, i.e., due to a combination of ventilation heterogeneity and flow asynchrony between lung units larger than acini. We induced conductive airway ventilation heterogeneity in 35 never-smoker normal subjects by histamine provocation and related the resulting changes in conductive ventilation heterogeneity (derived from the multiple-breath washout test) to corresponding changes in diffusing capacity, alveolar volume, and inspired vital capacity (derived from the single-breath DlCO method). Average conductive ventilation heterogeneity doubled ( P < 0.001), whereas DlCO decreased by 6% ( P < 0.001), with no correlation between individual data ( P > 0.1). Average inspired vital capacity and alveolar volume both decreased significantly by, respectively, 6 and 3%, and the individual changes in alveolar volume and in conductive ventilation heterogeneity were correlated ( r = −0.46; P = 0.006). These findings can be brought in agreement with recent modeling work, where specific ventilation heterogeneity resulting from different distributions of either inspired volume or end-expiratory lung volume have been shown to affect DlCO estimation errors in opposite ways. Even in the presence of flow asynchrony, these errors appear to largely cancel out in our experimental situation of histamine-induced conductive ventilation heterogeneity. Finally, we also predicted which alternative combination of specific ventilation heterogeneity and flow asynchrony could affect DlCO estimate in a more substantial fashion in diseased lungs, irrespective of any diffusion-dependent effects.

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