Acute Renal Failure in Kidney Transplant Patients Treated with Interferon Alpha 2b for Chronic Hepatitis C

Nephron ◽  
1996 ◽  
Vol 74 (3) ◽  
pp. 512-516 ◽  
Author(s):  
Lionel Rostaing ◽  
Anne Modesto ◽  
Emmanuel Baron ◽  
JeanMarc Cisterne ◽  
Marie Hélène Chabannier ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Kidney Transplant ◽  
Chronic Hepatitis C ◽  
Interferon Alpha ◽  
Transplant Patients ◽  
Interferon Alpha 2B ◽  
Kidney Transplant Patients

Pegylated interferon alpha 2b for chronic hepatitis C

2009 ◽  
Author(s):  
Tahany Awad ◽  
Kristian Thorlund ◽  
Goran Hauser ◽  
Mahasen Mabrouk ◽  
Davor Stimac ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Alpha ◽  
Pegylated Interferon ◽  
Pegylated Interferon Alpha ◽  
Interferon Alpha 2B

scholarly journals Early Prediction of Nonresponders to Treatment with Interferon Alpha-2B and Ribavirin in Patients with Chronic Hepatitis C

2003 ◽  
Vol 17 (8) ◽  
pp. 483-487 ◽  
Author(s):  
Louis WC Liu ◽  
George Tomlinson ◽  
Tony Mazzulli ◽  
Alison Murray ◽  
Jenny Heathcote
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Alpha ◽  
Baseline Viral Load ◽  
Hcv Rna ◽  
Interferon Alpha 2B ◽  
Quantitative Measurements ◽  
Treatment Responses

BACKGROUND: Treatment of chronic hepatitis C virus (HCV) infection with interferon alpha-2b and ribavirin is costly in terms of side effects, medical resources and drug costs. Furthermore, less than 50% of patients overall have a sustained virological response (SVR).OBJECTIVE: To determine if the log fall in HCV RNA between baseline and week 1 (b-wk1) and between baseline and week 4 (b-wk4) after starting treatment could identify the nonresponders.PATIENTS AND METHODS: Sixty-three patients who had completed a full course of therapy were identified. Quantitative measurements of HCV RNA were analyzed from stored sera, collected prospectively.RESULTS: SVR was achieved in 47.1% and 47.3% of patients in the b-wk1 and b-wk4 groups, respectively. No patients had an SVR with a fall in HCV RNA of less than 0.35 log10and 1.05 log10at week 1 and week 4, respectively. This accounted for 44.4% and 51.7% of the nonresponders in the b-wk1 and b-wk4 groups, respectively. Once the decline in viral load was known, genotype, age, sex and baseline viral load did not provide additional power in predicting treatment responses.CONCLUSION: A fall of 1.05 log10in HCV RNA at week 4 predicts those patients who will not respond, identifying one-half of all nonresponders; this allows therapy to be stopped early, without depriving any patient who would have an SVR from treatment.

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