Content of Sulfur Amino Acids and Vitamin B6 and Related Enzyme Activities in Rats with Chronic Renal Failure Fed a High Methionine Diet

Nephron ◽  
1996 ◽  
Vol 74 (1) ◽  
pp. 175-182 ◽  
Author(s):  
Kozo Asagi ◽  
Mitsuo Nakayama ◽  
Masaru Kobayashi ◽  
Shiro Awata ◽  
Kazuko Nakayama ◽  
...  
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Enzyme Activities ◽  
Vitamin B ◽  
Sulfur Amino Acids ◽  
Related Enzyme

scholarly journals Alterations in Sulfur Amino Acids as Biomarkers of Disease

2020 ◽  
Vol 150 (Supplement_1) ◽  
pp. 2532S-2537S ◽  
Author(s):  
Sally P Stabler
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Alcohol Use Disorder ◽  
Rna Synthesis ◽  
Megaloblastic Anemia ◽  
Serum Vitamin ◽  
Sulfur Amino Acids ◽  
Dna And Rna ◽  
Dna And Rna Synthesis

ABSTRACT Homocysteine (Hcy) is methylated by methionine synthase to form methionine with methyl-cobalamin as a cofactor. The reaction demethylates 5-methyltetrahydrofolate to tetrahydrofolate, which is required for DNA and RNA synthesis. Deficiency of either of the cobalamin (Cbl) and/or folate cofactors results in elevated Hcy and megaloblastic anemia. Elevated Hcy is a sensitive biomarker of Cbl and/or folate status and more specific than serum vitamin assays. Elevated Hcy normalizes when the correct vitamin is given. Elevated Hcy is associated with alcohol use disorder and drugs that target folate or Cbl metabolism, and is a risk factor for thrombotic vascular disease. Elevated methionine and cystathionine are associated with liver disease. Elevated Hcy, cystathionine, and cysteine, but not methionine, are common in patients with chronic renal failure. Higher cysteine predicts obesity and future weight gain. Serum S-adenosylhomocysteine (AdoHcy) is elevated in Cbl deficiency and chronic renal failure. Drugs that require methylation for catabolism may deplete liver S-adenosylmethionine and raise AdoHcy and Hcy. Deficiency of Cbl or folate or perturbations of their metabolism cause major changes in sulfur amino acids.

Disposal of exogenous amino acids by muscle in patients with chronic renal failure

1995 ◽  
Vol 62 (1) ◽  
pp. 136-142 ◽  
Author(s):  
G Garibotto ◽  
G Deferrari ◽  
C Robaudo ◽  
S Saffioti ◽  
A Sofia ◽  
...  
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure

Early alterations of plasma free amino acids in chronic renal failure

1990 ◽  
Vol 188 (2) ◽  
pp. 101-108 ◽  
Author(s):  
I. Ceballos ◽  
P. Chauveau ◽  
V. Guerin ◽  
J. Bardet ◽  
P. Parvy ◽  
...  
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Free Amino Acids ◽  
Free Amino ◽  
Plasma Free Amino Acids

Elimination of Amino Acids in Chronic Renal Failure

1986 ◽  
Vol 13 (6) ◽  
pp. 262-267
Author(s):  
W. Druml ◽  
G. Weinberger ◽  
U. Bürger ◽  
P. Balcke ◽  
A. Laggner ◽  
...  
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure

Vitamin B-6 metabolism is altered in chronic renal failure rats

1994 ◽  
Vol 14 (2) ◽  
pp. 271-278 ◽  
Author(s):  
Ien-Lan Wei ◽  
Tze-Kong Young
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Vitamin B

scholarly journals Progression of chronic renal failure in patients given ketoacids following amino acids

1987 ◽  
Vol 32 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Mackenzie Walser ◽  
Norman D. LaFrance ◽  
Lynne Ward ◽  
Mary Ann VanDuyn
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure

D-Amino acids in chronic renal failure and the effects of dialysis and urinary losses

Amino Acids ◽  
1994 ◽  
Vol 6 (3) ◽  
pp. 283-293 ◽  
Author(s):  
G. A. Young ◽  
S. Kendall ◽  
A. M. Brownjohn
Keyword(s):  
Amino Acids ◽  
Renal Failure ◽  
Chronic Renal Failure
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