Clinical Profile and Course and Outcome of Late Acute Rejection Episodes in Living-Related-Donor Renal Allograft Recipients

Nephron ◽  
1995 ◽  
Vol 71 (1) ◽  
pp. 40-43 ◽  
Author(s):  
R. Mittal ◽  
S.K. Agarwal ◽  
S.C. Dash ◽  
S. Saxena ◽  
S.C. Tiwari ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Renal Allograft ◽  
Clinical Profile ◽  
Related Donor ◽  
Living Related ◽  
Living Related Donor

scholarly journals Severe dengue in a living related donor renal allograft recipient

2015 ◽  
Vol 9 (2) ◽  
pp. 50-51
Author(s):  
V. Chaitanya ◽  
B.S. Lakshmi ◽  
A.C.V. Kumar ◽  
M.H.K. Reddy ◽  
P. Sandeep ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Severe Dengue ◽  
Renal Allograft Recipient ◽  
Related Donor ◽  
Living Related ◽  
Living Related Donor

Radiation dose-benefit analysis of hematopoietic stem cell grafting for tolerence induction across MHC barriers in living related donor renal allograft recipients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 3044-3044
Author(s):  
V. Shankar ◽  
C. Haritha ◽  
H. L. Trivedi ◽  
A. Vanikar ◽  
P. M. Modi ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
T Cell ◽  
Radiation Dose ◽  
Renal Allograft ◽  
Conditioning Regimen ◽  
Tolerance Induction ◽  
Hematopoietic Stem ◽  
Related Donor ◽  
Living Related ◽  
Living Related Donor

3044 Background: Donor specific immunologic tolerance protects an allograft from chronic rejection and allows discontinuation of chronic immunosuppressive therapy. Ahmedabad-tolerance induction protocol (A-TIP) allows grafting in living related donor (LRD) renal allograft recipients with persistent low-level MLHC. Present study aims to define of the ideal radiation dose needed for tolerance induction in patients undergoing A-TIP. Methods: 210 consecutive end stage renal disease patients recruited between May '05 through Mar '07 underwent renal transplantation (RTx) following A-TIP and negative Lymphocytotoxicity cross match (LCM). A-TIP includes (a) 2 DLI's (b) low intensity conditioning, and (c) HSC grafting.The conditioning regimen included fractionated low dose target specific radiation, cyclosporine, cyclophosphamide, anti T-cell a.b and treosulfan. All patients underwent subtotal lymphoid irradiation (STLI) targeting spleen, abdominal, iliac and inguinal lymph nodes, thoraco-lumbar vertebra and 75% of pelvis. Patients were randomized into 3 groups of 70 each: STLI 600, STLI 800, STLI 1000, corresponding to doses of 600cgy, 800cgy and 1000cgy delivered conventionally using 6MV/15MV photons. Unfractionated HSC procured from donor BM was administered into portal circulation, within 24 hours of achieving CD4+/CD8+ T cell count ≤ 10% of baseline. Donor specific cytotoxic antibodies were eliminated before RTx. Immunosuppression (ISp) was withdrawn 3–6 mo after RTx for patients with consistently positive chimerism. Tolerance - Robust (R), Prope (P) and Metastable (M) is defined as RT: Stable allograft function (fn.) for >100 days without ISp; PT: Early adequate, stable grafts fn. with no rejection episodes on minimum ISp; MT: Adequate graft fn. on ISp with single episode of steroid responsive ac. rejection. Results: See Table. Conclusions: The safe and effective dose for tolerance induction in LRD renal transplantation is 1000 cGy. [Table: see text] No significant financial relationships to disclose.

Initial experience with living-related donor liver transplantation in Rabin Medical Center, Israel

1997 ◽  
Vol 29 (6) ◽  
pp. 2633-2634 ◽  
Author(s):  
E. Mor ◽  
N. Bar-Nathan ◽  
D. Shmueli ◽  
E. Shaharabani ◽  
A. Yussim ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Medical Center ◽  
Initial Experience ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Related Donor ◽  
Living Related ◽  
Living Related Donor ◽  
Rabin Medical
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