Effect of Glucose Infusion on the Renal Transport of Purine Bases and Oxypurinol

Nephron ◽  
1995 ◽  
Vol 69 (4) ◽  
pp. 424-427 ◽  
Author(s):  
Yuji Moriwaki ◽  
Tetsuya Yamamoto ◽  
Sumio Takahashi ◽  
Michio Suda ◽  
Kazuya Higashino
1990 ◽  
Vol 3 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Justin T. Gerstle ◽  
Fritz R. Bech ◽  
Daniel B. Walsh ◽  
Jack L. Cronenwett

Nephron ◽  
1993 ◽  
Vol 65 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Tetsuya Yamamoto ◽  
Yuji Moriwaki ◽  
Sumio Takahashi ◽  
Yumiko Nasako ◽  
Kazuya Higashino

2004 ◽  
Vol 36 (9) ◽  
pp. 1543-1550 ◽  
Author(s):  
JAMES M. CARTER ◽  
ASKER E. JEUKENDRUP ◽  
CHRIS H. MANN ◽  
DAVID A. JONES

Metabolism ◽  
1999 ◽  
Vol 48 (3) ◽  
pp. 338-341 ◽  
Author(s):  
Tetsuya Yamamoto ◽  
Yuji Moriwaki ◽  
Sumio Takahashi ◽  
Zenta Tsutsumi ◽  
Jun-ichi Yamakita ◽  
...  

1982 ◽  
Vol 10 (2) ◽  
pp. 99-104
Author(s):  
Francisco Mauad-Filho ◽  
Edson Nunes de Morais ◽  
Joaquim Vaz Parente ◽  
Uilho Antonio Gomes ◽  
Renart Leite de Carvalho

1975 ◽  
Vol 34 (3) ◽  
pp. 375-382 ◽  
Author(s):  
N. W. Offer ◽  
M. V. Tas ◽  
R. F. E. Axford ◽  
R. A. Evans

1. Glucose in solution in saline, or saline alone, was administered to a group of twenty ewes during late pregnancy and again after lambing. Sequential blood samples were taken before and after the infusion and the concentration of plasma free amino acids was determined.2. The effect of glucose was to reduce the concentrations of all amino acids except alanine. The reduction was greatest for tryptophan in the pregnant sheep, but this amino acid showed no significant change in the lactating animals.3. An attempt to rank the amino acids on the basis of their response to glucose infusion indicated that, with the exception of tryptophan for the preparturient ewes, groups of essential amino acids could not be distinguished from each other. These groups were, for the preparturient sheep, valine, leucine, phenylalanine and isoleucine, and for the postparturient animals, isoleucine, lysine, methionine, valine and phenylalanine.


1975 ◽  
Vol 80 (1_Suppla) ◽  
pp. S42
Author(s):  
H.-J. Quabbe ◽  
W. Ramek ◽  
A. S. Luyckx

1975 ◽  
Vol 79 (3) ◽  
pp. 483-501 ◽  
Author(s):  
Erol Cerasi

ABSTRACT The effect of repeating a 60 min glucose infusion at a 40 to 70 min interval was investigated after an overnight fast in 14 healthy, non-obese subjects with normal glucose tolerance and normal insulin response to glucose administration. When a hyperglycaemic plateau of around 300 mg/100 ml was induced by the first glucose infusion, the insulin response to a second challenge was enhanced over the range of stimulations used. Both the early and late phase insulin responses were amplified, the enhancement being more marked with higher stimulatory levels of glucose. The blood glucose-insulin dose-response curve became steeper after pretreatment with glucose, the stimulatory threshold level not being altered. These findings suggest that the synergism between the glucose pretreatment, and the insulin releasing effect of glucose, is of multiplicative type, resulting in increase of the maximum effect of the glucose. The dose-dependency of this potentiation was investigated by keeping the second glucose challenge at a constant level and altering the dose of the first infusion. It was necessary to reach hyperglycaemias around and above 300 mg/100 ml during the first infusion in order to obtain enhancement of the insulin response to the second stimulus. The dose-response curve of the potentiating effect of glucose is thus displayed towards the right when compared with that describing the insulin releasing effect of glucose, which has its threshold around 100 mg/100 ml. It is suggested that glucose exerts a dual effect on the pancreatic islets: an immediate one which initiates the release of insulin, and a time-bound one which modulates the first action.


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