scholarly journals Recurrent IgA Nephropathy in a Renal Allograft Presenting as Crescentic Glomerulonephritis

Nephron ◽  
1994 ◽  
Vol 66 (1) ◽  
pp. 113-114 ◽  
Author(s):  
C.P. Streather ◽  
J.E. Scoble
2017 ◽  
Vol 45 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Rupali S. Avasare ◽  
Paul E. Rosenstiel ◽  
Ziad S. Zaky ◽  
Demetra S. Tsapepas ◽  
Gerald B. Appel ◽  
...  

Background: Most studies that have assessed the predictors of recurrent IgA nephropathy (IgAN) in the renal allograft have focused on post-transplant features. Identifying high-risk pre-transplant features of IgAN is useful for counseling patients and may help in tailoring post-transplant immunosuppression. Methods: We investigated the pre-transplant clinical and biopsy features of 62 patients with IgAN who received transplants at Columbia University Medical Center from 2001 to 2012 and compared the characteristics and outcomes of patients with IgAN recurrence to those without recurrence. The primary outcome was time to recurrent IgAN. Secondary outcomes were a composite of doubling of creatinine or allograft failure, and recurrent IgAN as a cause of allograft dysfunction. Results: Of the 62 patients, 14 had recurrent IgAN in the allograft. Mean time to recurrence was 2.75 years. Those with recurrent disease were younger at the time of native kidney biopsy (29 vs. 41 years, p < 0.0009). Black race and Hispanic ethnicity composed a higher proportion of the recurrent disease group. On multivariable analysis, significant predictors of recurrent IgAN included age at diagnosis (hazards ratio (HR) 0.911, 95% CI 0.85-0.98), burden of crescents on native biopsy (HR 1.21 per 10% increase in crescents, 95% CI 1.00-1.47) and allograft rejection (HR 3.59, 95% CI 1.10-11.7). Conclusions: Features of native IgAN can help predict the risk of recurrent disease in the renal allograft. In particular, immunologically active disease represented by earlier age of onset and greater burden of crescents on native biopsy is more likely to recur after transplant.


2010 ◽  
Vol 73 (01) ◽  
pp. 68-71 ◽  
Author(s):  
T. Tsuchiya ◽  
S. Ito ◽  
Y. Yamaguchi ◽  
Y. Moriyama ◽  
H. Ehara ◽  
...  

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 579
Author(s):  
H J. Jeong ◽  
Y M. Cho ◽  
M S. Kim ◽  
Y S. Kim ◽  
S I. Kim ◽  
...  

2021 ◽  
Author(s):  
Catherine R. Kavanagh ◽  
Francesca Zanoni ◽  
Rita Leal ◽  
Namrata G. Jain ◽  
Megan Nicole Stack ◽  
...  

2005 ◽  
Vol 20 (6) ◽  
pp. 1214-1221 ◽  
Author(s):  
Arun Chandrakantan ◽  
Piti Ratanapanichkich ◽  
Mowaffaq Said ◽  
Catherine V. Barker ◽  
Bruce A. Julian

Nephrology ◽  
2003 ◽  
Vol 8 (s4) ◽  
pp. A115-A115
Author(s):  
Hiroko CHIKAMOTO ◽  
Motoshi HATTORI ◽  
Shigeru HORITA ◽  
Toshihiro SAWAI ◽  
Tae OHMORI ◽  
...  

1984 ◽  
Vol 73 (12) ◽  
pp. 1856-1860 ◽  
Author(s):  
Takehisa YURI ◽  
Keita TATEISHI ◽  
Naoyasu SUGISHITA ◽  
Yoshihiro FUKUDA ◽  
Yoshio TANI ◽  
...  

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