Tubular Secretion of Tamm-Horsfall Protein Is Decreased in Type 1 (Insulin-Dependent) Diabetic Patients with Diabetic Nephropathy

Nephron ◽  
1993 ◽  
Vol 65 (2) ◽  
pp. 227-231 ◽  
Author(s):  
Ole Torffvit ◽  
Carl-David Agardh
Keyword(s):  
Diabetic Nephropathy ◽  
Tubular Secretion ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals Differential glycaemic effects of potato, rice and spaghetti in Type 1 (insulin-dependent) diabetic patients at constant insulinaemia

Diabetologia ◽  
1986 ◽  
Vol 29 (6) ◽  
pp. 358-361 ◽  
Author(s):  
K. Hermansen ◽  
O. Rasmussen ◽  
J. Arnfred ◽  
E. Winther ◽  
O. Schmitz
Keyword(s):  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Decreased distensibility of resistance vessels of the skin in type 1 (insulin-dependent) diabetic patients with microangiopathy

1987 ◽  
Vol 72 (1) ◽  
pp. 123-130 ◽  
Author(s):  
J. Kastrup ◽  
T. Nørgaard ◽  
H.-H. Parving ◽  
N. A. Lassen
Keyword(s):  
Blood Flow ◽  
Inverse Correlation ◽  
Diabetic Patients ◽  
Resistance Vessels ◽  
Head Up Tilt ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Type 1 Diabetic Patients ◽  
Term Type

1. The distensibility of the resistance vessels of the skin at the dorsum of the foot was determined in 11 long-term type 1 (insulin-dependent) diabetic patients with nephropathy and retinopathy, nine short-term type 1 diabetic patients without clinical microangiopathy and in nine healthy non-diabetic subjects. 2. Blood flow was measured by the local 133Xexenon washout technique in a vascular bed locally paralysed by the injection of histamine. Blood flow was measured before, during and after a 40 mmHg increase of the vascular transmural pressure, induced by head-up tilt. 3. The mean increase in blood flow during headup tilt was only 24% in diabetic subjects with and 48% in diabetic patients without clinical microangiopathy, compared with 79% in normal non-diabetic subjects (P < 0.0005 and P < 0.05, respectively). 4. An inverse correlation between microvascular distensibility and degree of hyalinosis of the terminal arterioles in biopsies from the skin was demonstrated (r = − 0.57, P < 0.001). 5. Our results suggest that terminal arteriolar hyalinosis reduces the microvascular distensibility and probably increases the minimal vascular resistance, thereby impeding hyperaemic responses.

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