Isoniazid-Induced Neurotoxicity in Chronic Dialysis Patients: Report of Three Cases and a Review of the Literature

Nephron ◽  
1993 ◽  
Vol 64 (2) ◽  
pp. 303-306 ◽  
Author(s):  
Mark S. Siskind ◽  
Dana Thienemann ◽  
Linda Kirlin
1997 ◽  
Vol 8 (3) ◽  
pp. 509-514
Author(s):  
J Farrell ◽  
B Bastani

Dialysis-related amyloidosis secondary to beta-2-microglobulin (beta 2m) deposits is a common complication of long-term dialysis patients and is responsible for significant morbidity with potential mortality. Beta 2m amyloid has a propensity to deposit in the osteoarticular tissues, particularly in large bones close to the joint spaces, and in synovial membranes and carpal tunnel tissue. Older age at the onset of dialysis and the duration of dialysis are two important risk factors for development of this disease. The high-flux, more biocompatible membranes have been shown to remove and adsorb beta 2m more efficiently than the cellulosic membranes. This study presents the case of a chronic dialysis patient who developed recurrent arthritis of the left knee, followed by carpal tunnel syndrome; biopsy of the patient's knee showed very large aggregates of beta 2m amyloid deposits in the tendon sheets. A brief review of the literature on this subject is also presented.


2017 ◽  
Vol 68 (2) ◽  
pp. 354-357 ◽  
Author(s):  
Andrei Niculae ◽  
Cristiana David ◽  
Razvan Florin Ion Dragomirescu ◽  
Ileana Peride ◽  
Flavia Liliana Turcu ◽  
...  

Once recombinant human erythropoietin (r-HuEPO) was introduced in daily practice, huge steps were made in combating the adverse effects induced by anemia in chronic kidney disease population. Still, r-HuEPO resistance and the doses ensuring the maximum therapeutic benefit remain matters of debate. The aim of our study was to assess the correlation between the presence and the degree of inflammation and the r-HuEPO requirements in chronic dialysis patients. We conducted a 2 years prospective study on 146 patients undergoing chronic dialysis treated with r-HuEPO. Based on their average CRP (C-reactive protein) levels, obtained from repeated samplings at 3 months interval, 3 groups were formed; we noted in each group the average values of r-HuEPO prescribed to achieve the optimum hemoglobin levels according to the dialysis best practice guidelines and all the adverse effects of the therapy. A direct correlation was observed between CRP levels and r-HuEPO requirements in the first 2 groups of patients (CRP under 6 mg/L and CRP values 6-20 mg/L), with significant increase in r-HuEPO doses between groups (p [ 0.001); the third group, CRP values over 20 mg/dL, showed a minor, insignificant increase in average r-HuEPO doses compared to mild inflammation group (p = 0.199) and more adverse effects of the therapy (p [ 0.05). Inflammation is an important determinant of anemia in chronic dialysis patients and can induce an increase in the doses of r-HuEPO. However, prescribing excessive r-HuEPO doses is not the answer in severe inflammatory status, due to lack of response and possible adverse effects.


2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii511-iii511
Author(s):  
Jose Tarcisio Giffoni de Carvalho ◽  
Marion Schneider ◽  
Lilian Cuppari ◽  
Caren Cristina Grabulosa ◽  
Silvia Regina Manfredi ◽  
...  

2021 ◽  
Vol 6 (4) ◽  
pp. S237
Author(s):  
J. SANTACRUZ ◽  
C. Santacruz Tipanta ◽  
A. Vasquez Pérez ◽  
P. Reinoso ◽  
S. Carlotta ◽  
...  

2006 ◽  
Vol 39 (1) ◽  
pp. 281-288 ◽  
Author(s):  
T. Pliakogiannis ◽  
L. Trpeski ◽  
H. Taskapan ◽  
H. Shah ◽  
M. Ahmad ◽  
...  

1998 ◽  
Vol 32 (4) ◽  
pp. 629-634 ◽  
Author(s):  
CO Stehman-Breen ◽  
S Emerson ◽  
D Gretch ◽  
RJ Johnson

The Lancet ◽  
1979 ◽  
Vol 314 (8150) ◽  
pp. 1024-1025 ◽  
Author(s):  
A. Caralps ◽  
J. Lloveras ◽  
J. Andreu ◽  
A. Brulles ◽  
J. Masramon ◽  
...  

2011 ◽  
Vol 27 (4) ◽  
pp. 1585-1590 ◽  
Author(s):  
H.-F. Lin ◽  
Y.-H. Li ◽  
C.-H. Wang ◽  
C.-L. Chou ◽  
D.-J. Kuo ◽  
...  

2015 ◽  
Vol 28 (3) ◽  
pp. 235-239 ◽  
Author(s):  
Mohamed E. Elsayed ◽  
Austin G. Stack

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