scholarly journals A Role for the Extracellular Calcium-Sensing Receptor in Cell-Cell Communication in Pancreatic Islets of Langerhans

2008 ◽  
Vol 22 (5-6) ◽  
pp. 557-566 ◽  
Author(s):  
Isidora Kitsou-Mylona ◽  
Christopher J. Burns ◽  
Paul E. Squires ◽  
Shanta J. Persaud ◽  
Peter M. Jones
Keyword(s):  
Pancreatic Islets ◽  
Islets Of Langerhans ◽  
Cell Communication ◽  
Extracellular Calcium ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Pancreatic Islets Of Langerhans ◽  
Cell Cell

scholarly journals Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases

2006 ◽  
Vol 190 (3) ◽  
pp. 703-710 ◽  
Author(s):  
Elizabeth Gray ◽  
Dany Muller ◽  
Paul E Squires ◽  
Henry Asare-Anane ◽  
Guo-Cai Huang ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Protein Kinases ◽  
Islets Of Langerhans ◽  
Divalent Cations ◽  
Human Islets ◽  
Extracellular Calcium ◽  
Calcium Sensing Receptor ◽  
Calcium Calmodulin Dependent ◽  
Calcium Sensing ◽  
Pancreatic Islets Of Langerhans

The extracellular calcium-sensing receptor (CaR) is usually associated with systemic Ca2+ homeostasis, but the CaR is also expressed in many other tissues, including pancreatic islets of Langerhans. In the present study, we have used human islets and an insulin-secreting cell line (MIN6) to investigate the effects of CaR activation using the calcimimetic R-568, a CaR agonist that activates the CaR at physiological concentrations of extracellular Ca2+. CaR activation initiated a marked but transient insulin secretory response from both human islets and MIN6 cells at a sub-stimulatory concentration of glucose, and further enhanced glucose-induced insulin secretion. CaR-induced insulin secretion was reduced by inhibitors of phospholipase C or calcium–calmodulin-dependent kinases, but not by a protein kinase C inhibitor. CaR activation was also associated with an activation of p42/44 mitogen-activated protein kinases (MAPK), and CaR-induced insulin secretion was reduced by an inhibitor of p42/44 MAPK activation. We suggest that the β-cell CaR is activated by divalent cations co-released with insulin, and that this may be an important mechanism of intra-islet communication between β-cells.

The extracellular calcium-sensing receptor and cell–cell signaling in epithelia

Cell Calcium ◽  
2004 ◽  
Vol 35 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Aldebaran M Hofer ◽  
Andrea Gerbino ◽  
Rosa Caroppo ◽  
Silvana Curci
Keyword(s):  
Cell Signaling ◽  
Extracellular Calcium ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Cell Cell
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