scholarly journals Cell Death Induced by Uridine 5'-triphosphate (UTP) in Contrast to Adenosine 5'-triphosphate (ATP) in Human Epidermoid Carcinoma Cells (A-431)

2008 ◽  
Vol 22 (5-6) ◽  
pp. 441-454 ◽  
Author(s):  
Thomas Völkl ◽  
Alexandra Ogilvie ◽  
Winfried Neuhuber ◽  
Adaling Ogilvie
1986 ◽  
Vol 127 (1) ◽  
pp. 175-182 ◽  
Author(s):  
Carol L. MacLeod ◽  
Andrew Luk ◽  
Janice Castagnola ◽  
Maureen Cronin ◽  
John Mendelsohn

Acta Naturae ◽  
2012 ◽  
Vol 4 (3) ◽  
pp. 88-94 ◽  
Author(s):  
M. A. Savitskaya ◽  
M. S. Vildanova ◽  
O. P. Kisurina-Evgenieva ◽  
E. A. Smirnova ◽  
G. E. Onischenko

Vitamin E derivatives are known to act as agents exhibiting cytotoxity against tumor cells. The effect of vitamin E succinate on human epidermoid carcinoma cell line A431 was investigated in this study using live imaging, immunocytochemistry, and transmission electron microscopy. -Tocopheryl succinate-induced apoptotic cell death in A431 cells was shown to be both dose- and time-dependent. The hyperproduction of reactive oxygen species, changes in size, shape and ultrastructural characteristics of mitochondria followed by the release of cytochrome c from mitochondria to cytosol were observed. These results suggest that -tocopheryl succinate induces apoptosis that occurs via the mitochondrial pathway. Mitochondria are shown to be crucial targets in -tocopheryl succinate-induced caspase-dependent cell death in human carcinoma A431 cells.


1993 ◽  
Vol 101 (4) ◽  
pp. 528-531 ◽  
Author(s):  
Markus Grewe ◽  
Uwe. Trefzer ◽  
Annette Ballhorn ◽  
Karin Gyufko ◽  
Hanspeter Henninger ◽  
...  

2006 ◽  
Vol 66 (3) ◽  
pp. 852-859 ◽  
Author(s):  
Nand K. Sah ◽  
Anupama Munshi ◽  
Marvette Hobbs ◽  
Bing Z. Carter ◽  
Michael Andreeff ◽  
...  

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