Continuous Ambulatory Peritoneal Dialysis and Vitamin D

Nephron ◽  
1988 ◽  
Vol 48 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Jayson Rapoport ◽  
Shraga Shany ◽  
Cidio Chaimovitz
Keyword(s):  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis

scholarly journals Efficacy of Weekly Split versus Single Doses of Ergocalciferol on Serum 25-Hydroxyvitamin D among Patients on Continuous Ambulatory Peritoneal Dialysis: A Randomized Controlled Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Naowanit Nata ◽  
Jessada Kanchanasinitth ◽  
Pamila Tasanavipas ◽  
Ouppatham Supasyndh ◽  
Bancha Satirapoj
Keyword(s):  
Vitamin D ◽  
Single Dose ◽  
Peritoneal Dialysis ◽  
Vitamin D Deficiency ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Dose Group ◽  
Vitamin D Supplementation ◽  
Split Dose ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Background. Vitamin D deficiency is a common problem among patients on continuous ambulatory peritoneal dialysis (CAPD). Vitamin D supplementation leads to reduced serum parathyroid hormone levels and improved cardiovascular markers. Different doses and time intervals of oral vitamin D supplementation may differ in each patient on dialysis. The study aimed to evaluate the efficacy of weekly split and single dose of ergocalciferol at 60,000 IU on serum 25-hydroxyvitamin D (25(OH)D) among patients on CAPD. Methods. A randomized study was conducted among patients on CAPD with vitamin D deficiency or insufficiency (25(OH)D < 30 ng/mL). Patients were randomly assigned to two groups: the split dose group was given ergocalciferol 20,000 IU three times weekly and the single dose group was given ergocalciferol 60,000 IU once weekly for 8 weeks. Main outcomes measured serum 25(OH)D concentrations, serum calcium, serum phosphate, and intact parathyroid levels at 8 weeks after being enrolled. Results. Of 128 screened patients, 50 met the criteria for eligibility and were randomized. At 8 weeks after treatment, mean serum 25(OH)D concentrations significantly increased from baseline 22.7 ± 5.9 to 29.5 ± 9.5 ng/mL P = 0.004 in the split dose group and 22.9 ± 5.3 to 31.2 ± 12.3 ng/mL P = 0.003 in the single dose group. No significant change was found in increase of serum 25(OH)D between the two groups P = 0.561 . At the end of study, a similar proportion of patients in both groups reached the desirable serum concentration of 25(OH)D ≥ 30 ng/mL (60% in the single group vs. 40% in the split group, P = 0.258 ). No significant cases of hypercalcemia, hyperphosphatemia, or serious adverse events occurred during the study. Conclusion. Weekly single and split doses of ergocalciferol 60,000 IU achieved similar effects on serum 25(OH)D levels among patients on CAPD with vitamin D insufficiency or deficiency, suggesting that weekly single dose would be prescribed for adequate vitamin D repletion. This trial is registered with TCTR20200821005.

Effects of Continuous Ambulatory Peritoneal Dialysis (CAPD) on Renal Osteodystrophy

1985 ◽  
Vol 5 (1) ◽  
pp. 53-55 ◽  
Author(s):  
Carmelo Loschiavo ◽  
Antonia Fabris ◽  
Silvano Adami ◽  
Luciana Tomelleri ◽  
Nicola Tessitore ◽  
...  
Keyword(s):  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Renal Osteodystrophy ◽  
Bone Lesions ◽  
Vitamin D Metabolites ◽  
Vitamin D Metabolism ◽  
Mean Values ◽  
Bone Biopsies ◽  
Normal Mean

The authors performed a metabolic and morphologic investigation of calcium metabolism in 22 patients on continuous ambulatory peritoneal dialysis (CAPD), selected as the first procedure. The patients were kept on a diet containing about 30 Kcal/ kg, 1 g/kg of protein, 950 mg of phosphate and 1500 mg of calcium per day. They showed normal mean values of serum calcium, phosphate, alkaline phosphatase, total protein and albumin at the start and after six, 12 and 21 months of CAPD. Serum PTH levels showed a progressive decrease over 21 months. Serum 25-OH-D3 were low at start and showed a further decrease after 12 months of CAPD. Before and during CAPD, serum 1,25 (OH)2D3 levels were undetectable. The bone mineral content was within normal range at start and showed a slight decrease after 12 months of CAPD. In 64% of the patients, bone biopsies, obtained from the iliac crest at the start showed osteomalacia, either isolated or associated with hyperparathyroidism. After 12 months, osteomalacia was still evident in 71% of this group. The authors concluded that dietary restriction of phosphate is important in preventing secondary hyperparathyroidism in patients on CAPD. However, prevalence of osteomalacia is due to defective vitamin D metabolism and its management requires administration of vitamin D metabolites. In its morphological aspects and clinical features, renal osteodystrophy (RO) may differ significantly between patients on CAPD and those on hemodialysis (1–3). In addition, workers have reported conflicting opinions concerning the incidence and severity of bone lesions in CAPD patients (4–6). We undertook this investigation in order to evaluate the evolution and clinical, biochemical and morphologic aspects of RO in 22 ESRD patients treated with CAPD after long-term restriction of dietary protein and phosphate.

Vitamin D and Vitamin-D-Binding Protein Kinetics in Patients Treated with Continuous Ambulatory Peritoneal Dialysis (CAPD)

1989 ◽  
Vol 9 (4) ◽  
pp. 281-284 ◽  
Author(s):  
Preben Joffe ◽  
James G. Heat
Keyword(s):  
Mass Transfer ◽  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Binding Protein ◽  
Serum Levels ◽  
Vitamin D Binding Protein ◽  
Normal Range ◽  
Protein Kinetics ◽  
25 Hydroxycholecalciferol

Serum and dialysate levels of 25-hydroxycholecalciferol (25-0HD3), 1,25 dihydrox ycholecalciferol (1,25(0H)2D3), and vitamin-D-binding protein (DBP) were measured in 14 patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Serum levels of 25-0HD3 and DBP were within normal range (29.1 ± 22.9 nmollL and 5.9 ± 1.1 μmol/L, respectively). Serum levels of 1,25-(0H)2D3 were subnormal in all «16 pmol/L) but one. In 5 patients, dialysate concentrations of 25-0HD3 were 2.3 ± 0.9 nmol/L, the rest had levels <1.0 nmol/L. Small quantities of 1,25-(0H)2D3 were found in the dialysate effluents. DBP could be detected in the dialysate in all patients (0.24 ± 0.06 μmol/L). Mass transfer (MT) of 25-0HD3 and DBP were respectively -10.4 ± 8.3 nmol/24 h and -1.46 ± 0.46 μmol/24 h. Peritoneal clearances of 25-0HD3 and DBP were low (0.40 ± 0.37 mL/min and 0.18 ± 0.06 mL/ min, respectively. We conclude that CAPD leads to losses of 25-0HD3 and DBP. However, the peritoneal loss of DBP is well compensated and does not result in serum deficiency. Serum 25-0HD3 levels did not correlate with time on CAPD.

Some hormones, minerals and Vitamin D in continuous ambulatory peritoneal dialysis

1987 ◽  
Vol 19 (4) ◽  
pp. 453-459
Author(s):  
L. Janicka ◽  
A. Książek ◽  
Z. Twardowski ◽  
F. Kokot
Keyword(s):  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis

Evaluation of vitamin D-binding protein and vitamin D metabolite loss in children on continuous ambulatory peritoneal dialysis

1992 ◽  
Vol 17 (3) ◽  
pp. 389-398 ◽  
Author(s):  
Wen-tse Chen ◽  
Kanji Yamaoka ◽  
Shigeo Nakajima ◽  
Yoshihisa Tanaka ◽  
Takehisa Yamamoto ◽  
...  
Keyword(s):  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Binding Protein ◽  
Vitamin D Binding Protein

A Cross Sectional Assessment of Serum Vitamin O ANO Trigl Ycerioe Concentrations in a CAPO Population

1984 ◽  
Vol 4 (4) ◽  
pp. 232-235 ◽  
Author(s):  
Karl D. Nolph ◽  
Leonor Ryan ◽  
Barbara Prowant ◽  
Zbylut Twardowski
Keyword(s):  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Serum Vitamin ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Therapeutic Interventions ◽  
Serum Concentrations ◽  
Cross Sectional ◽  
Vitamin D Levels

A cross sectional analysis of 41 patients on continuous ambulatory peritoneal dialysis (CAPD) for six to 54 months (mean, 21.7) showed that 58.5% and 19.5% had low levels of 1,25-(OH)2 vitamin D and 25-OH vitamin D respectively. C-terminal and N-terminal parathyroid hormone (PTH) levels were elevated in 85 and 75%, respectively. N-terminal PTH correlated (r -0.31, p < 0.05) with serum inorganic phosphorus, but not with vitamin D levels. Triglyceride and cholesterol concentrations were elevated in 76% and 19%; HDL cholesterol was low in 37%. Except for PTH levels, none of the other above measurements correlated with time on CAPD. The findings suggest that most CAPD patients have low 1,25(OH)2 vitamin D and elevated PTH and triglyceride serum concentrations. More study should be made concerning the clinical significance of and proper therapeutic interventions in these circumstances. Reduced serum concentrations of vitamin D metabolities and increased serum triglyceride concentrations have been described frequently in patients on continuous ambulatory peritoneal dialysis (CAPD) (1–4). In 41 patients in our CAPD program, we did a cross-sectional assessment of vitamin D and triglyceride levels to quantitate the frequency and severity of these problems. We correlated serum levels of vitamin D and triglyceride with time on CAPD and other variables.

scholarly journals Minerals, vitamin D, and parathyroid hormone in continuous ambulatory peritoneal dialysis

1982 ◽  
Vol 21 (6) ◽  
pp. 862-867 ◽  
Author(s):  
James A. Delmez ◽  
Eduardo Slatopolsky ◽  
Kevin J. Martin ◽  
Barbara N. Gearing ◽  
Herschel R. Harter
Keyword(s):  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Parathyroid Hormone ◽  
Continuous Ambulatory Peritoneal Dialysis

Scanning Electron Microscopy of Staphylococcus Epidermidis Adherence to Continuous Ambulatory Peritoneal Dialysis Catheters

1985 ◽  
Vol 43 ◽  
pp. 520-521
Author(s):  
William J. Lamoreaux ◽  
David L. Smalley ◽  
Larry M. Baddour ◽  
Alfred P. Kraus
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Staphylococcus Epidermidis ◽  
Sterile Saline ◽  
Intravascular Devices ◽  
Capd Patient ◽  
Scanning Electron

Infections associated with the use of intravascular devices have been documented and have been reported to be related to duration of catheter usage. Recently, Eaton et al. reported that Staphylococcus epidermidis may attach to silastic catheters used in continuous ambulatory peritoneal dialysis (CAPD) treatment. The following study presents findings using scanning electron microscopy (SEM) of S. epidermidis adherence to silastic catheters in an in vitro model. In addition, sections of polyvinyl chloride (PVC) dialysis bags were also evaluated by SEM.The S. epidermidis strain RP62A which had been obtained in a previous outbreak of coagulase-negative staphylococcal sepsis at local hospitals was used in these experiments. The strain produced surface slime on exposure to glucose, whereas a nonadherent variant RP62A-NA, which was also used in these studies, failed to produce slime. Strains were grown overnight on blood agar plates at 37°C, harvested from the surface and resuspended in sterile saline (0.85%), centrifuged (3,000 rpm for 10 minutes) and then washed twice in 0.1 M phosphate-buffered saline at pH 7.0. Organisms were resuspended at a concentration of ca. 106 CFU/ml in: a) sterile unused dianeal at 4.25% dextrose, b) sterile unused dianeal at 1.5% dextrose, c) sterile used dialysate previously containing 4.25% dextrose taken from a CAPD patient, and d) sterile used dialysate previously containing 1.5% dextrose taken from a CAPD patient.

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