Abstract.
As both hypoglycaemia and hyperglycaemia may modify plasma levels pancreatic polypeptide (PP), we measured plasma PP by a homologous radioimmunoassay in seven diabetics who were admitted to the hospital in overt diabetic ketoacidosis (initial blood glucose 27.1–55.0 mmol/l). None had circulating PP-antibodies. All were treated with continuous infusion of insulin and fluids.
Before starting treatment, plasma PP ranged from 2585–136 pmol/l (mean 629 pmol/l). Following treatment plasma PP decreased gradually in all patients. The following morning mean plasma PP was 242 pmol/l, 67 pmol/l when one uraemic patient was excluded. The normal value is less than 100 pmol/l.
This study shows that plasma PP is clearly elevated in diabetic ketoacidosis and decreases following treatment.
Cefazolin-Induced Encephalopathy in a Uraemic Patient