In Reply.—
We thank Dannenhoffer and Crawford for their thoughtful comments on our recent study of testosterone treatment of constitutional delay. We agree that the size of the study population was relatively small, and that subject randomization resulted in a significant difference in mean height at the time of entry into the study. Nevertheless, we believe the data still support the conclusion that short-term testosterone treatment can result in significant growth acceleration in this population. In general, linear growth in children correlates better with bone age than with chronologic age, and the skeletal ages of the two groups in this study were not significantly different.
Short term linear growth in asthmatic children during treatment with prednisolone.