Cyclosporin A in Insulin-Dependent Diabetes mellitus of Recent Onset: A Pilot Study in Children

1988 ◽  
Vol 29 (5-6) ◽  
pp. 177-184 ◽  
Author(s):  
C. Lévy-Marchal ◽  
P. Czernichow
Keyword(s):  
Diabetes Mellitus ◽  
Pilot Study ◽  
Cyclosporin A ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Recent Onset ◽  
Insulin Dependent

Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset

Science ◽  
1984 ◽  
Vol 223 (4643) ◽  
pp. 1362-1367 ◽  
Author(s):  
C. Stiller ◽  
J Dupre ◽  
M Gent ◽  
M. Jenner ◽  
P. Keown ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Recent Onset ◽  
Insulin Dependent

scholarly journals Efficacy and Safety of Allogenic Canine Adipose Tissue-derived Mesenchymal Stem Cell Therapy for Insulin Dependent Diabetes Mellitus in Dogs: A pilot study

2019 ◽  
Author(s):  
Sung-Yong Rhew ◽  
Woo-Jin Song ◽  
Qiang Li ◽  
Ju-Hyun An ◽  
Hyung-Kyu Chae ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Pilot Study ◽  
Diabetic Complications ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
C Peptide ◽  
Insulin Dependent

Abstract Background Since mesenchymal stem cells (MSCs) possess regenerative and immunomodulatory properties, and are capable of controlling the immune dysregulation that leads to β-cell destruction, stem cell transplantation could be used in the management of insulin-dependent diabetes mellitus (IDDM). In this pilot study, we assessed whether canine adipose tissue-derived MSC (cAT-MSC) therapy could be an option for treatment of canine diabetes mellitus. Results With the written informed consent of the owners, allogenic cAT-MSCs were infused intravenously in IDDM dogs. C-peptide was elevated by about 5–15% in 3 of 4 cases, and hyperlipidemia was resolved in 2 of 4 cases. Additionally, fructosamine and Hb/A1c levels were improved in 2 of 4 cases. Conclusions Considering that C-peptide secretion capacity and lipid metabolism are related to diabetic complications, these results suggest that cAT-MSC therapy in diabetic dogs might help to improve the insulin secretory capacity of dogs with IDDM and prevent diabetic complications.

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