Effect of Acute Intravenous Growth Hormone-Releasing Factor on Plasma Prolactin in Short Children and Patients with Growth Hormone Deficiency

1985 ◽  
Vol 22 (1-2) ◽  
pp. 46-51 ◽  
Author(s):  
P.G. Chatelain ◽  
G. Sassolas ◽  
N. Catbeh ◽  
S. Bio-Laporte ◽  
S. Ferry ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Plasma Prolactin ◽  
Growth Hormone Releasing Factor ◽  
Short Children

scholarly journals Comparison of food intake and height increment in normal and constitutionally short children and in children with growth hormone deficiency.

1979 ◽  
Vol 26 (1) ◽  
pp. 133-136 ◽  
Author(s):  
YOSHIAKI OKADA ◽  
KAZUO WATANABE ◽  
TORU TAKEUCHI ◽  
TOSHIO ONISHI ◽  
KIYOJI TANAKA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Food Intake ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Height Increment ◽  
Short Children

Prospective clinical trial of human growth hormone in short children without growth hormone deficiency

1984 ◽  
Vol 104 (2) ◽  
pp. 172-176 ◽  
Author(s):  
J.M. Gertner ◽  
M. Genel ◽  
S.P. Gianfredi ◽  
R.L. Hintz ◽  
R.G. Rosenfeld ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Prospective Clinical Trial ◽  
Hormone Deficiency ◽  
Short Children

The Role of Auxologic and Growth Factor Measurements in the Diagnosis of Growth Hormone Deficiency

PEDIATRICS ◽  
1998 ◽  
Vol 102 (Supplement_3) ◽  
pp. 524-526
Author(s):  
Raymond L. Hintz
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Growth Hormone Deficiency ◽  
Short Stature ◽  
The Body ◽  
Hormone Deficiency ◽  
Insulin Like Growth Factor ◽  
Growth Study ◽  
Short Children ◽  
National Cooperative

The use of auxologic measurements in the diagnosis of short stature in children has a long history in pediatric endocrinology, and they have even been used as the primary criteria in selecting children for growth hormone (GH) therapy. Certainly, an abnormality in the control of growth is more likely in short children than in children of normal stature. However, most studies have shown little or no value of auxologic criteria in differentiating short children who have classic growth hormone deficiency (GHD) from short children who do not. In National Cooperative Growth Study Substudy VI, in more than 6000 children being assessed for short stature, the overall mean height SD score was −2.5 ± 1.1 and the body mass index standard deviation score was −0.5 ± 1.4. However, there were no significant differences in these measures between the patients who were found subsequently to have GHD and those who were not. There also was no consistent difference in the growth rates between the patients with classic GHD and those short children without a diagnosis of GHD. This probably reflects the fact that we are dealing with a selected population of children who were referred for short stature and are further selecting those who are the shortest for additional investigation. Growth factor measurements have been somewhat more useful in selecting patients with GHD and have been proposed as primary diagnostic criteria. However, in National Cooperative Growth Study Substudy VI, only small differences in the levels of insulin-like growth factor I and insulin-like growth factor binding protein 3 were seen between the patients who were selected for GH treatment and those who were not. Many studies indicate that the primary value of growth factor measurements is to exclude patients who are unlikely to have GHD or to identify those patients in whom an expedited work-up should be performed. The diagnosis of GHD remains difficult and must be based on all of the data possible and the best judgment of an experienced clinician. Even under ideal circumstances, errors of both overdiagnosis and underdiagnosis of GHD still are likely.

scholarly journals GROWTH HORMONE RELEASING FACTOR GENE STRUCTURE IN GROWTH HORMONE DEFICIENCY

1984 ◽  
Vol 18 ◽  
pp. 172A-172A ◽  
Author(s):  
John S Parks ◽  
Laura C Sexton ◽  
Edwin F Slott ◽  
Richard L Mallonee ◽  
John A Phillips
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Gene Structure ◽  
Hormone Deficiency ◽  
Growth Hormone Releasing Factor ◽  
Factor Gene

Do Short Children Secrete Insufficient Growth Hormone?

PEDIATRICS ◽  
1985 ◽  
Vol 76 (3) ◽  
pp. 355-360
Author(s):  
Zvi Zadik ◽  
Stuart A. Chalew ◽  
Salvatore Raiti ◽  
A. Avinoam Kowarski
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Normal Growth ◽  
Mean Value ◽  
Hormone Deficiency ◽  
Short Children ◽  
Stimulation Tests ◽  
Normal Stature ◽  
Hormone Responses ◽  
The Mean

The 24-hour integrated concentration of growth hormone from 46 children of normal stature was compared with that of 90 short children. Nineteen of the short children had classic growth hormone deficiency by standard pharmacologic growth hormone stimulation tests. Seventy-one children had normal growth hormone responses to stimulation. The mean integrated concentration of growth hormone for children with normal stature (6.6 ± 1.9 ng/mL) was greater than the mean value for those with normal stimulated growth hormone (3.8 ± 2.3 ng/mL) and greater than the mean value for those with growth hormone deficiency (1.6 ± 0.6 ng/mL); differences between groups were all statistically significant (P < .0001). Forty-five percent of children with normal stimulated growth hormone responses had integrated concentration of growth hormone within the range of values for the group with growth hormone deficiency; this finding may provide the explanation for their poor growth. Thus, patients with normal growth hormone responses have a spectrum of spontaneous growth hormone secretion ranging from normal to impaired. Recent reports indicate that children with normal growth hormone responses who have very low integrated concentration of growth hormone may have the potential to improve their growth with growth hormone therapy. Therefore, use of the integrated concentration of growth hormone may be a more effective method than standard pharmacologic stimulation tests for determining which short children are potentially able to respond to growth hormone therapy.

scholarly journals Evaluation of Clinical Features and Growth Hormone Deficiency in Short Children Born Small For Gestational Age

2018 ◽  
Vol 40 (3) ◽  
pp. 253-257
Author(s):  
Tomomi IKEGAMI ◽  
Shunsuke ARAKI ◽  
Mami KUWAMURA ◽  
Aoi TAKU ◽  
Reiko SAITO ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Clinical Features ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Hormone Deficiency ◽  
Short Children
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