Dissociation of Luteinizing Hormone and Follicle-Stimulating Hormone Control Mechanisms in Male and Female Rats by Neonatal Administration of Estradiol Benzoate or Testosterone Propionate

1984 ◽  
Vol 19 (2) ◽  
pp. 108-116 ◽  
Author(s):  
E. Aguilar ◽  
A. Tejero ◽  
M.D. Vaticón ◽  
Fernández Galaz
Keyword(s):  
Luteinizing Hormone ◽  
Testosterone Propionate ◽  
Follicle Stimulating Hormone ◽  
Estradiol Benzoate ◽  
Female Rats ◽  
Control Mechanisms ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration ◽  
Hormone Control

CHANGES IN SECRETION OF LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE INDUCED BY HYPOVOLAEMIA IN RATS

1981 ◽  
Vol 88 (1) ◽  
pp. 97-101 ◽  
Author(s):  
V. W. K. LEE ◽  
D. M. DE KRETSER
Keyword(s):  
Luteinizing Hormone ◽  
Blood Volume ◽  
Follicle Stimulating Hormone ◽  
Blood Sampling ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Egg Albumen ◽  
Stimulating Hormone

Changes in levels of LH and FSH in the circulation were examined during repeated blood sampling in untreated rats and gonadectomized male and female rats treated with oestrogen, progesterone and thyroxine. Blood depletion induced a significant increase in levels of LH in steroid-treated rats but the increase was abolished when the depleted blood volume was replaced with egg albumen. The rise in LH was less dramatic in male than in female animals. In untreated rats, levels of LH either decreased or did not change with repeated phlebotomy. In contrast, the levels of FSH either did not alter or were lowered in all situations.

THE EFFECT OF NEONATAL ADMINISTRATION OF SEX HORMONES ON THE TURNOVER OF HEPATIC MICROSOMAL PHOSPHOLIPID IN MALE AND FEMALE RATS

1971 ◽  
Vol 49 (4) ◽  
pp. 659-665 ◽  
Author(s):  
Y. C. TOH
Keyword(s):  
Testosterone Propionate ◽  
Liver Microsomes ◽  
Total Content ◽  
P Uptake ◽  
Female Rats ◽  
Radioactive Phosphorus ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration ◽  
Microsomal Phospholipid

SUMMARY The effect of neonatal administration of testosterone propionate and oestradiol benzoate on the metabolism of microsomal phospholipid in the liver of male and female rats was studied. Males had a greater uptake of radioactive phosphorus than females. Gonadectomy at the age of 4 weeks reduced the incorporation of 32P into the microsomal phospholipid. Administration of testosterone significantly increased 32P uptake both in the intact and ovariectomized females as well as in the castrated males, whereas oestradiol produced no effect. A sex difference of total microsomal phospholipid phosphorus was also found in the gonadectomized rats. Oestrogen caused no change in the intact animals but restored the level of phospholipid in ovariectomized female rats. On the other hand, testosterone significantly increased the total content of the phospholipid in the liver microsomes of both intact and gonadectomized male and female rats.

GONADOTROPHIN PATTERNS IN MALE AND FEMALE RATS:

1968 ◽  
Vol 58 (4) ◽  
pp. 600-612 ◽  
Author(s):  
Robert Boyd ◽  
Donald C. Johnson
Keyword(s):  
Ascorbic Acid ◽  
Testosterone Propionate ◽  
Female Rats ◽  
Female Rat ◽  
Feedback Effects ◽  
Male And Female ◽  
Prostate Weight ◽  
Male And Female Rats ◽  
Males And Females ◽  
Normal Males

ABSTRACT The effects of various doses of testosterone propionate (TP) upon the release of luteinizing hormone (LH or ICSH) from the hypophysis of a gonadectomized male or female rat were compared. Prostate weight in hypophysectomized male parabiotic partners was used to evaluate the quantity of circulating LH. Hypophyseal LH was measured by the ovarian ascorbic acid depletion method. Males castrated when 45 days old secreted significantly more LH and had three times the amount of pituitary LH as ovariectomized females. Administration of 25 μg TP daily reduced the amount of LH in the plasma, and increased the amount in the pituitary gland, in both sexes. Treatment with 50 μg caused a further reduction in plasma LH in males, but not in females, while pituitary levels in both were equal to that of their respective controls. LH fell to the same low level in partners of males or females receiving 100 μg TP. When gonadectomized at 39 days, males and females had the same amount of plasma LH, but males had more stored hormone. Pituitary levels were unchanged from controls following treatment with 12.5, 25 or 50 μg TP daily, but plasma values dropped an equal amount in both sexes with the latter two doses. Androgenized males or females, gonadectomized when 39 days old, were very sensitive to the effects of TP and plasma LH was significantly reduced with 12.5 μg daily. Pituitary LH in androgenized males was higher than that of normal males but was reduced to normal by small amounts of TP. The amount of stored LH in androgenized females was not different from that of normal females and it was unchanged by any dose of TP tested. Results are consistent with the conclusion that the male hypothalamic-hypophyseal axis is at least as sensitive as the female axis to the negative feedback effects of TP. Androgenization increases the sensitivity to TP in both males and females.

Aspartic acid administered neonatally affects ventilation of male and female rats differently

1986 ◽  
Vol 61 (2) ◽  
pp. 780-784 ◽  
Author(s):  
E. H. Schlenker ◽  
M. Goldman
Keyword(s):  
Aspartic Acid ◽  
Ventilatory Response ◽  
Minute Ventilation ◽  
Female Rats ◽  
Male Rats ◽  
Metabolic Rates ◽  
Control Male ◽  
Male And Female ◽  
Male And Female Rats ◽  
Neonatal Administration

In this study ventilation was evaluated in 12-mo-old male and female rats who had received large doses of aspartic acid neonatally. Rats of both sexes treated with aspartic acid were obese, stunted, and exhibited hypogonadism. Although metabolic rates of the aspartic acid-treated rats were not different compared with sex-matched controls, ventilatory patterns were different. Aspartic acid-treated females breathed with a smaller tidal volume (VT), higher frequency (f), and similar minute ventilation (VE) compared with control females. This pattern is commonly observed in many patients who are obese. The aspartic acid-treated females responded to hypercapnic and hypoxic challenges by increasing f more than VT. Tissue pocket gases (PCO2 and PO2) of aspartic acid-treated females were normal. In contrast, aspartic acid-treated males hypoventilated compared with control males. Tissue pocket gas values suggested that aspartic acid-treated males were hypoxemic and hypercapnic. Moreover, the response of aspartic acid-treated males to hypercapnia was parallel to but was less than that of control male rats. The ventilatory response of aspartic acid-treated male rats to hypoxia was blunted. This study has shown that neonatal administration of aspartic acid causes a decreased ventilation and blunted response to hypoxia in adult male but not female rats.

SOME BIOLOGICAL PROPERTIES OF A POTENT FOLLICLE STIMULATING HORMONE PREPARATION

1965 ◽  
Vol 48 (3) ◽  
pp. 439-445 ◽  
Author(s):  
Harold Papkoff
Keyword(s):  
Interstitial Cell ◽  
Follicle Stimulating Hormone ◽  
Intrinsic Property ◽  
Biological Properties ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Stimulating Hormone

ABSTRACT A preparation of ovine follicle stimulating hormone (FSH) which is approximately 50 times as active as NIH-FSH-S1 has been tested in hypophysectomized male and female rats and found to be a potent steroidogenic factor. Contamination of the FSH preparation with interstitial cell-stimulating hormone (ICSH, LH) was found to be very low (0.006–0.016 unit/mg) and could not account for the observed activity. In addition, treatment of the FSH preparation with 6 m urea and neuraminidase indicates that the steroidogenic activity is either an intrinsic property of the FSH molecule or a discrete entity which differs chemically from ICSH.

INHIBITION OF SEXUAL DEVELOPMENT IN MALE AND FEMALE RATS TREATED WITH VARIOUS STEROIDS AT THE AGE OF FIVE DAYS

1965 ◽  
Vol 49 (2) ◽  
pp. 193-206 ◽  
Author(s):  
Fred A. Kind ◽  
A. Folch Pi ◽  
M. Maqueo ◽  
L. Herrera Lasso ◽  
A. Oriol ◽  
...  
Keyword(s):  
Sexual Development ◽  
Testosterone Propionate ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

ABSTRACT The effect of various steroids injected into 5 day old male and female rats was evaluated at the age of 45 days. In the males the degree in which testes and accessory sex tissues were atrophied, and in the females the degree of inhibition of luteinization were the indices. Various synthetic oestrogens were potent inhibitors of sexual development in both sexes while androgens were less active. The activity of several oestrogens in this test does not correlate with oestrogenic potency as measured in the uterotrophic test. Testosterone propionate produced moderate atrophy of testes and accessory sex tissue but spermatogenesis was not impaired.

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