Oxidant-lnduced Increase in Vascular Permeability Is Inhibited by Oral Administration of S-5682 (Daflon® 500 mg) and Alpha-Tocopherol

1997 ◽  
Vol 17 (1) ◽  
pp. 18-20 ◽  
Author(s):  
E. Bouskela ◽  
E. Svensjö ◽  
F.Z.G.A. Cyrino ◽  
L. Lerond
Keyword(s):  
Oral Administration ◽  
Vascular Permeability ◽  
Alpha Tocopherol

Serum Alpha-Tocopherol Levels in Relation to Serum Lipids and Lipoproteins after Oral Administration of Vitamin E1

2015 ◽  
pp. 159-165
Author(s):  
R. S. London ◽  
G. S. Sundaram ◽  
S. Manimekalai ◽  
L. Murphy ◽  
M. A. Reynolds ◽  
...  
Keyword(s):  
Oral Administration ◽  
Serum Lipids ◽  
Alpha Tocopherol ◽  
Lipids And Lipoproteins

scholarly journals ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF RUBUS FRUTICOSUS AND ZIZYPHUS VULGARIS METHANOL EXTRACTS

2017 ◽  
Vol 9 (2) ◽  
pp. 69
Author(s):  
Asma Meziti ◽  
Hamama Bouriche ◽  
Meziti Hichem ◽  
Seoussen Kada ◽  
Abderrahmane Senator ◽  
...  
Keyword(s):  
Oral Administration ◽  
Antioxidant Capacity ◽  
Vascular Permeability ◽  
Dna Cleavage ◽  
Total Antioxidant Capacity ◽  
Rubus Fruticosus ◽  
Total Antioxidant ◽  
Anti Inflammatory

<p class="Default"><strong>Objective</strong>:<strong> </strong>This report is an attempt to study the phenolic composition of <em>Rubus fruticosus </em>(RFE) and<em> Zizyphus vulgaris (</em>ZVE<em>) </em>methanol<em> </em>extracts<em> and </em>evaluate their antioxidant and anti-inflammatory effects <em>in-vitro</em> and <em>in-vivo</em>.</p><p><strong>Methods: </strong>Total phenolic and total flavonoids contents of extracts were determined by spectrophotometric methods. Phenolic compounds were identified by<strong> </strong>HPLC-TOF/MS. The antioxidant activities were evaluated <em>in vitro</em> using DPPH, ABTS and FRAP assays. The effect of RFE and ZVE<em> </em>on DNA cleavage induced by H<sub>2</sub>O<sub>2</sub> UV-photolysis was also investigated. The antioxidant effect of RFE and ZVE was tested <em>in vivo</em> using the blood total antioxidant capacity test in mice. On the other hand, the anti-inflammatory activity was assessed <em>in vivo</em> using two models of acute inflammation ear edema and vascular permeability.</p><p><strong>Results: </strong>The phytochemical analysis of these extracts showed that RFE possesses higher polyphenolic and flavonoid content than ZVE. in the same way RFE exerted the highest antioxidant capacity with IC<sub> 50 </sub>value of 14 µg/ml in DPPH assay, 1.58 mmol of Trolox E/mg extract and 3.39 of mmol FesO<sub>4</sub>/mg extract in ABTS, and FRAP assay respectively. The studied extracts showed a concentration-dependent protective effect on DNA cleavage induced by H<sub>2</sub>O<sub>2</sub> UV-photolysis. The daily oral administration of 200 mg/kg of RFE or ZVE during three weeks showed an improvement of the blood total antioxidant capacity; the HT<sub>50</sub> values were151.45 min and 146.72 min for the groups treated with RFE and ZVE, respectively <em>versus</em> 122.5 min for the control group. The topical application of 2 mg/ear of RFE inhibited the croton oil-induced ear edema by 75.72%, while the inhibition exerted by ZVE was 64.24%. These inhibitions were higher than that of indomethacin, used as a reference. Moreover, the oral administration of 400 mg/kg of RFE inhibited significantly (33.57%) acetic acid induced vascular permeability in mice. However, this effect was lower than this of indomethacin. The inhibition effect exerted by ZVE was not significant.</p><p><strong>Conclusion</strong><strong>:</strong><strong> </strong>The results obtained in this investigation showed that RFE possesses strong antioxidant and anti-inflammatory potential in comparison with ZVE, which may be attributed to the presence of polyphenolic phytoconstituents.</p>

Pharmacokinetics and Bioavailability of the RRR and All Racemic Stereoisomers of Alpha-Tocopherol in Humans After Single Oral Administration

1993 ◽  
Vol 33 (1) ◽  
pp. 84-88 ◽  
Author(s):  
Kenneth E. Ferslew ◽  
Robert V. Acuff ◽  
Ernest A. Daigneault ◽  
Thomas W. Woolley ◽  
Paul E. Stanton
Keyword(s):  
Oral Administration ◽  
Alpha Tocopherol ◽  
Single Oral Administration

Reduction in plasma or Skin Alpha Tocopherol Concentration With Long-term Oral Administration of Beta-carottene in Humans and Mice

1992 ◽  
Vol 84 (20) ◽  
pp. 1559-1565 ◽  
Author(s):  
M. J. Xu ◽  
P. M. Plezia ◽  
D. S. Alberts ◽  
S. S. Emerson ◽  
Y. M. Peng ◽  
...  
Keyword(s):  
Oral Administration ◽  
Alpha Tocopherol ◽  
Tocopherol Concentration

scholarly journals Biodiscrimination of alpha-tocopherol stereoisomers in humans after oral administration

1997 ◽  
Vol 65 (3) ◽  
pp. 785-789 ◽  
Author(s):  
C Kiyose ◽  
R Muramatsu ◽  
Y Kameyama ◽  
T Ueda ◽  
O Igarashi
Keyword(s):  
Oral Administration ◽  
Alpha Tocopherol
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