Dose-Dependent Effects of an Anabolic Steroid, Nandrolone Phenylpropionate (Durabolin), on Body Composition and Muscle Protein Metabolism in Female Rats

1991 ◽  
Vol 35 (3) ◽  
pp. 141-147 ◽  
Author(s):  
J.J. Choo ◽  
P.W. Emery ◽  
N.J. Rothwell
Keyword(s):  
Body Composition ◽  
Anabolic Steroid ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Female Rats ◽  
Muscle Protein Metabolism ◽  
Dose Dependent ◽  
Nandrolone Phenylpropionate

Synergistic effects of citrulline supplementation and exercise on performance in male rats: evidence for implication of protein and energy metabolisms

2017 ◽  
Vol 131 (8) ◽  
pp. 775-790 ◽  
Author(s):  
Arthur Goron ◽  
Frédéric Lamarche ◽  
Valérie Cunin ◽  
Hervé Dubouchaud ◽  
Christophe Hourdé ◽  
...  
Keyword(s):  
Body Composition ◽  
Protein Synthesis ◽  
Endurance Training ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Synergistic Effects ◽  
Male Rats ◽  
Healthy Male ◽  
Proteomic Approach ◽  
Muscle Protein Metabolism

Background: Exercise and citrulline (CIT) are both regulators of muscle protein metabolism. However, the combination of both has been under-studied yet may have synergistic effects on muscle metabolism and performance. Methods: Three-month-old healthy male rats were randomly assigned to be fed ad libitum for 4 weeks with either a citrulline-enriched diet (1 g·kg−1·day−1) (CIT) or an isonitrogenous standard diet (by addition of nonessential amino acid) (Ctrl) and trained (running on treadmill 5 days·week−1) (ex) or not. Maximal endurance activity and body composition were assessed, and muscle protein metabolism (protein synthesis, proteomic approach) and energy metabolism [energy expenditure, mitochondrial metabolism] were explored. Results: Body composition was affected by exercise but not by CIT supplementation. Endurance training was associated with a higher maximal endurance capacity than sedentary groups (P<0.001), and running time was 14% higher in the CITex group than the Ctrlex group (139±4 min versus 122±6 min, P<0.05). Both endurance training and CIT supplementation alone increased muscle protein synthesis (by +27% and +33%, respectively, versus Ctrl, P<0.05) with an additive effect (+48% versus Ctrl, P<0.05). Mitochondrial metabolism was modulated by exercise but not directly by CIT supplementation. However, the proteomic approach demonstrated that CIT supplementation was able to affect energy metabolism, probably due to activation of pathways generating acetyl-CoA. Conclusion: CIT supplementation and endurance training in healthy male rats modulates both muscle protein and energy metabolisms, with synergic effects on an array of parameters, including performance and protein synthesis.

Effects of the anabolic steroid stanozolol on growth and protein metabolism in the rat

1987 ◽  
Vol 114 (3) ◽  
pp. 373-381 ◽  
Author(s):  
P. C. Bates ◽  
L. F. Chew ◽  
D. J. Millward
Keyword(s):  
Protein Synthesis ◽  
Anabolic Steroid ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Muscle Growth ◽  
Female Rats ◽  
Male Rats ◽  
Anabolic Action ◽  
Rna Concentration

ABSTRACT The effects of the anabolic steroid stanozolol on whole body and muscle growth and protein metabolism in the rat have been examined. No responses could be found in normal well-fed male rats. Female rats responded to 1 mg/kg per day with an increased body and skeletal muscle growth rate and an increase in muscle protein synthesis. The anabolic action on muscle protein synthesis was due to increased RNA concentration with no change in the rate of protein synthesis per unit RNA (KRNA). Investigation of any anticatabolic effects of stanozolol treatment in male rats deprived of food for 24 h indicated no response of protein balance and turnover. However, rats treated with catabolic doses of corticosterone (50 mg/kg per day) did respond to stanozolol with decreased muscle growth inhibition due to better-maintained muscle protein synthesis. The latter response was due to a reversal of the corticosterone-induced reduction of KRNA, but with no effect on RNA concentration. Thus there appear to be at least two effects of stanozolol; an anabolic action evident only in female rats, involving increased muscle RNA concentrations, and an anticatabolic action involving inhibition of the corticosterone-induced fall in muscle RNA activity. In both cases, stanozolol influenced muscle protein synthesis with no evident effects on protein degradation. J. Endocr. (1987) 114, 373–381

1460 Muscle protein metabolism of growing Holstein × Gyr heifers

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 709-709
Author(s):  
F. A. S. Silva ◽  
S. C. Valadares Filho ◽  
L. N. Rennó ◽  
S. A. Santos ◽  
D. Zanetti ◽  
...  
Keyword(s):  
Protein Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Metabolism

Postabsorptive muscle protein metabolism in type 1 diabetic patients after pancreas transplantation

2000 ◽  
Vol 37 (4) ◽  
pp. 219-224 ◽  
Author(s):  
L. Luzi ◽  
L. Piceni Sereni ◽  
M. Spessot ◽  
R. Dodesini ◽  
M.R. Pastore ◽  
...  
Keyword(s):  
Protein Metabolism ◽  
Pancreas Transplantation ◽  
Muscle Protein ◽  
Diabetic Patients ◽  
Muscle Protein Metabolism ◽  
Type 1 Diabetic Patients

Resistance Exercise, Aging, Disuse, and Muscle Protein Metabolism

2021 ◽  
pp. 2249-2278
Author(s):  
James McKendry ◽  
Tanner Stokes ◽  
Jonathan C. Mcleod ◽  
Stuart M. Phillips
Keyword(s):  
Resistance Exercise ◽  
Protein Metabolism ◽  
Muscle Protein ◽  
Muscle Protein Metabolism

scholarly journals Effect of Dietary Thyroxine on Muscle Protein Metabolism and Abdominal Fat Content in Broiler Chicken in Hot and Moderate Environments

1990 ◽  
Vol 61 (12) ◽  
pp. 1107-1112
Author(s):  
Kunioki HAYASHI ◽  
Shunichi KUKITA ◽  
Michiko MUKAI ◽  
Masaaki TOYOMIZU ◽  
Yuichiro TOMITA
Keyword(s):  
Protein Metabolism ◽  
Broiler Chicken ◽  
Muscle Protein ◽  
Abdominal Fat ◽  
Fat Content ◽  
Muscle Protein Metabolism
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