Alterations and Reversibility of the Effects of Gossypol Acetic Acid on the Intestinal Uptake of End Product Nutrients in Normal and Protein Calorie-Malnourished Male Rats

1991 ◽  
Vol 35 (1) ◽  
pp. 53-60 ◽  
Author(s):  
S. Chadha ◽  
S.N. Sanyal ◽  
U. Kanwar
Keyword(s):  
Acetic Acid ◽  
Male Rats ◽  
Intestinal Uptake ◽  
Gossypol Acetic Acid

Antifertility Efficacy of Gossypol Acetic Acid in Male Rats

Andrologia ◽  
2009 ◽  
Vol 14 (3) ◽  
pp. 270-275 ◽  
Author(s):  
G.F. WEINBAUER ◽  
E. ROVAN ◽  
J. FRICK
Keyword(s):  
Acetic Acid ◽  
Male Rats ◽  
Gossypol Acetic Acid

Radioiron Utilization and Gossypol Acetic Acid in Male Rats

1985 ◽  
Vol 8 (1-2) ◽  
pp. 69-82 ◽  
Author(s):  
J. N. Tone ◽  
D. R. Jensen
Keyword(s):  
Acetic Acid ◽  
Male Rats ◽  
Gossypol Acetic Acid

Mutual anti-oxidative effect of gossypol acetic acid and gossypol–iron complex on hepatic lipid peroxidation in male rats

2009 ◽  
Vol 47 (11) ◽  
pp. 2735-2741 ◽  
Author(s):  
A.S. El-Sharaky ◽  
M.M. Wahby ◽  
M.M. Bader El-Dein ◽  
R.A. Fawzy ◽  
I.N. El-Shahawy
Keyword(s):  
Lipid Peroxidation ◽  
Acetic Acid ◽  
Iron Complex ◽  
Male Rats ◽  
Hepatic Lipid ◽  
Gossypol Acetic Acid ◽  
Hepatic Lipid Peroxidation ◽  
Oxidative Effect

scholarly journals Ulcer Protective and Ulcer Healing Activities of Aqueous and Methanolic Extracts of Leaves of Rumex Bequaertii De Wild (Polygonaceae) in Rats

2015 ◽  
Vol 6 (2) ◽  
pp. 61
Author(s):  
Gilbert Ateufack ◽  
Breuil R. Dongmo Feudjio ◽  
William Nana Yousseu ◽  
Albert D. Atsamo ◽  
Albert Kamanyi
Keyword(s):  
Acetic Acid ◽  
Significant Variation ◽  
Healing Process ◽  
Negative Control ◽  
Chronic Ulcer ◽  
Male Rats ◽  
Control Group ◽  
Traditional Use ◽  
Mucus Production ◽  
Methanolic Extracts

The aqueous and methanolic extracts of Rumex bequaertii leaves were investigated for their ability to prevent and treated ulceration of the gastric mucosa in animal models.For this, adult male rats three to four months old and weighing on average 180 g were used for both tests. The extracts were tested orally at doses of 125, 250 and 500 mg/kg, on ulcerations experimentally induced by HCl/ethanol and pylorus ligation (acute ulcer) and acetic acid (chronic ulcer).These extracts showed protective and healing properties on ulcer induced models. A dose of 500 mg/kg of the two extracts inhibited ulceration induced by HCl/ethanol by 98.86 and 91.59 % respectively. With pyloric ligation, no significant variation of the volume of gastric juices, pH and gastric acidity was observed compared to the negative control rats. The aqueous extract alone at different doses presented a significant reduction of the ulceration surface resulting from chronic ulcer induced with acetic acid compared to the negative control group that received distilled water. For all three models of gastric ulcer induction used, the mass of mucus significantly increased in the groups that received the extracts. There was no significant variation in plasmatic nitric oxide (NO) concentrationand gastric supernatant of rats treated with both extracts compared to both control groups. These results reveal that the healing process of the extracts is not achieved through the NO pathway. This process could be due to increase in mucus production and thus supports its traditional use of the plant

scholarly journals Gossypol Acetic Acid Attenuates Cardiac Ischemia/Reperfusion Injury in Rats via an Antiferroptotic Mechanism

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1667
Author(s):  
Jian-Hong Lin ◽  
Kun-Ta Yang ◽  
Pei-Ching Ting ◽  
Yu-Po Luo ◽  
Ding-Jyun Lin ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Cell Death ◽  
Acetic Acid ◽  
Ischemia Reperfusion ◽  
Neonatal Rat ◽  
Mrna Levels ◽  
H9c2 Cells ◽  
Rat Cardiomyocytes ◽  
Protein Levels ◽  
Gossypol Acetic Acid

Myocardial ischemia/reperfusion (I/R) injury has been associated with ferroptosis, which is characterized by an iron-dependent accumulation of lipid peroxide to lethal levels. Gossypol acetic acid (GAA), a natural product taken from the seeds of cotton plants, prevents oxidative stress. However, the effects of GAA on myocardial I/R-induced ferroptosis remain unclear. This study investigated the ability of GAA to attenuate I/R-induced ferroptosis in cardiomyocytes along with the underlying mechanisms in a well-established rat model of myocardial I/R and isolated neonatal rat cardiomyocytes. H9c2 cells and cardiomyocytes were treated with the ferroptosis inducers erastin, RSL3, and Fe-SP. GAA could protect H9c2 cells against ferroptotic cell death caused by these ferroptosis inducers by decreasing the production of malondialdehyde and reactive oxygen species, chelating iron content, and downregulating mRNA levels of Ptgs2. GAA could prevent oxygen-glucose deprivation/reperfusion-induced cell death and lipid peroxidation in the cardiomyocytes. Moreover, GAA significantly attenuated myocardial infarct size, reduced lipid peroxidation, decreased the mRNA levels of the ferroptosis markers Ptgs2 and Acsl4, decreased the protein levels of ACSL4 and NRF2, and increased the protein levels of GPX4 in I/R-induced ex vivo rat hearts. Thus, GAA may play a cytoprotectant role in ferroptosis-induced cardiomyocyte death and myocardial I/R-induced ferroptotic cell death.

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