Intermediate Density Lipoprotein-Apolipoprotein B Turnover in Rabbits Fed Semipurified Diets Containing Casein or Soy Protein

1990 ◽  
Vol 34 (2) ◽  
pp. 98-103 ◽  
Author(s):  
S. Samman ◽  
P. Khosla ◽  
K.K. Carroll
2018 ◽  
Vol 19 (11) ◽  
pp. 3593 ◽  
Author(s):  
Hong Yang ◽  
Ningya Zhang ◽  
Emmanuel Okoro ◽  
Zhongmao Guo

Passage of apolipoprotein B-containing lipoproteins (apoB-LPs), i.e., triglyceride-rich lipoproteins (TRLs), intermediate-density lipoproteins (IDLs), and low-density lipoproteins (LDLs), through the endothelial monolayer occurs in normal and atherosclerotic arteries. Among these lipoproteins, TRLs and IDLs are apoE-rich apoB-LPs (E/B-LPs). Recycling of TRL-associated apoE has been shown to form apoE-carrying high-density lipoprotein (HDL)-like (HDLE) particles in many types of cells. The current report studied the formation of HDLE particles by transcytosis of apoB-LPs through mouse aortic endothelial cells (MAECs). Our data indicated that passage of radiolabeled apoB-LPs, rich or poor in apoE, through the MAEC monolayer is inhibited by filipin and unlabeled competitor lipoproteins, suggesting that MAECs transport apoB-LPs via a caveolae-mediated pathway. The cholesterol and apoE in the cell-untreated E/B-LPs, TRLs, IDLs, and LDLs distributed primarily in the low-density (LD) fractions (d ≤ 1.063). A substantial portion of the cholesterol and apoE that passed through the MAEC monolayer was allotted into the high-density (HD) (d > 1.063) fractions. In contrast, apoB was detectable only in the LD fractions before or after apoB-LPs were incubated with the MAEC monolayer, suggesting that apoB-LPs pass through the MAEC monolayer in the forms of apoB-containing LD particles and apoE-containing HD particles.


1969 ◽  
Vol 130 ◽  
pp. 680-683 ◽  
Author(s):  
Gerald R. Faloona ◽  
Bruce N. Stewart ◽  
Melvin Fried

2007 ◽  
Vol 195 (2) ◽  
pp. e28-e34 ◽  
Author(s):  
Barbara J. Meyer ◽  
Laurence Duvillard ◽  
Alice Owen ◽  
Christopher J. Packard ◽  
Muriel J. Caslake

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