Effect of Prolonged Galactose Consumption on Galactose Tolerance in Young Healthy Humans

1990 ◽  
Vol 34 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Inès Birlouez-Aragon ◽  
Suleiman Alloussi
Keyword(s):  
Healthy Humans ◽  
Galactose Tolerance

Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans

2003 ◽  
Vol 1 (3) ◽  
pp. 211-218 ◽  
Author(s):  
Heather J. Chial ◽  
Michael Camilleri ◽  
Irene Ferber ◽  
Silvia Delgado-Aros ◽  
Duane Burton ◽  
...  
Keyword(s):  
Healthy Humans

Diurnal time course of pain perception in healthy humans

2006 ◽  
Vol 37 (01) ◽  
Author(s):  
CG Bachmann ◽  
C Harder ◽  
A Antal ◽  
P Baier ◽  
T Tings ◽  
...  
Keyword(s):  
Time Course ◽  
Pain Perception ◽  
Healthy Humans

315-OR: Hyperglycemia Increases Central Aortic Stiffness in Response to Insulin in Healthy Humans

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 315-OR
Author(s):  
WILLIAM B. HORTON ◽  
LINDA JAHN ◽  
LEE HARTLINE ◽  
JAMES T. PATRIE ◽  
EUGENE BARRETT
Keyword(s):  
Aortic Stiffness ◽  
Healthy Humans

1910-P: Effects of Glucagon Concentrations on Splanchnic and Leg Glucagon Extraction in Healthy Humans

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1910-P
Author(s):  
FNU RUCHI ◽  
YOGESH R. YADAV ◽  
DAVIDE ROMERES ◽  
SAFIA SAWLEH ◽  
LINDA M. BENSON ◽  
...  
Keyword(s):  
Healthy Humans

Effect of stress hormones on splanchnic substrate and insulin disposal after glucose ingestion in healthy humans

Diabetes ◽  
1987 ◽  
Vol 36 (2) ◽  
pp. 127-135 ◽  
Author(s):  
W. K. Waldhausl ◽  
S. Gasic ◽  
P. Bratusch-Marrain ◽  
M. Komjati ◽  
A. Korn
Keyword(s):  
Stress Hormones ◽  
Healthy Humans ◽  
Glucose Ingestion

XMODULATION IN MICEAND MEN: IL-10 PRODUCING CELLS INBLOOD AND LYMPHOID TISSUE

2008 ◽  
Vol 31 (4) ◽  
pp. 3
Author(s):  
L Barrett ◽  
M Grant ◽  
R Liwski ◽  
K West
Keyword(s):  
Immune System ◽  
Peripheral Blood ◽  
Lymphoid Tissue ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
White Blood Cells ◽  
Interleukin 10 ◽  
Healthy Individuals ◽  
Human Immune System ◽  
Healthy Humans

Background: The human immune system provides remarkable protection from a plethora of pathogens, but can cause damage when activated for a prolonged time (as inpersistent infections) or against self (autoimmunity). Therefore, mechanisms of immune system downregulation and control are imperative. There is little data on how the immune system is controlled in healthy individuals. We recently described a novel population of white blood cells that constitutively produce the immunomodulatory cytokine interleukin-10 (IL-10). Our objective was to further delineate the distribution of these cells in human and mouse models, as well as potential triggers for interleukin-10 production in vitro. Methods: Human and animal protocols were reviewed and approved by the institutional ethics board and animal care facilities, and informed consent was obtained from all human donors. The ex vivo percentage of peripheral blood CD36^+IL-10^+ mononuclear cells was assessed by intracellular flow cytometry in 10 healthy individuals. IL-10 production after exposure to twoCD36 ligands, thrombospondin and oxidized low density lipoprotein (oxLDL) was measured at 8 hours. Peripheral blood mononuclear cells and splenocytes from BL/6 (n=5) and Balb/c (n=1) micewere assessed for CD36^+IL-10^+ cells ex vivo as well. Results: The percentage of CD36^+IL-10^+ cells in peripheral blood fromhealthy individuals ranges between 0.1% and 0.9%. The percentage was similar in mouse peripheral blood, with a range of 0.4%-1.1%. These cells were also found in mouse spleen at a higher frequency than peripherally (1.1-1.5%). Human CD36^+IL-10^+ cells have more IL-10 when exposed to thrombospondin, oxLDL. Conclusions: Our novel population of IL-10 producing cells is found not only in healthy humans, but also in lymphoid tissue and blood from pathogen free mice. This highlights the evolutionary conservation of the cell across species, and suggests an important homeostatic function. The physiologic ligands for CD36 are ubiquitous in circulation, and ourin vitro data suggests a link between CD36 ligation and IL-10 production. IL-10 is a known immune system modulator, and its production by these cells may help maintain homeostaticcontrol of the immune system.

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