Hepatic Cholesterogenesis and Cholesterol 7α-Hydroxylase Activity in Hamsters Fed Diets Enriched with Pectins and/or Cholesterol

1987 ◽  
Vol 31 (1) ◽  
pp. 61-68 ◽  
Author(s):  
R. Sablé-Amplis ◽  
R. Sicart ◽  
D. Dupouy
Keyword(s):  
Hydroxylase Activity ◽  
Hepatic Cholesterogenesis

Evidence for impaired 21-hydroxylase activity in patients with septic shock

2004 ◽  
Vol 112 (S 1) ◽  
Author(s):  
MWA Angstwurm ◽  
A Rashidi-Kia ◽  
M Bidlingmeier ◽  
J Schopohl ◽  
R Gaertner
Keyword(s):  
Septic Shock ◽  
Hydroxylase Activity

16α-HYDROXYLASE ACTIVITY IN UTERINE TISSUE OF THE RHESUS MONKEY

1973 ◽  
Vol 71 (4_Suppl) ◽  
pp. S4 ◽  
Author(s):  
M. Breckwoldt ◽  
A. Trautwein ◽  
B. P. Lisboa
Keyword(s):  
Rhesus Monkey ◽  
Uterine Tissue ◽  
Hydroxylase Activity

scholarly journals Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 350
Author(s):  
Julianty Frost ◽  
Mark Frost ◽  
Michael Batie ◽  
Hao Jiang ◽  
Sonia Rocha
Keyword(s):  
Gene Expression ◽  
Hypoxia Inducible Factor ◽  
Transcriptional Regulator ◽  
Hydroxylase Activity ◽  
Control Of Gene Expression ◽  
Prolyl Hydroxylases ◽  
Chromatin Organisation ◽  
Sense And Respond ◽  
Almost All ◽  
And Function

Hypoxia—reduction in oxygen availability—plays key roles in both physiological and pathological processes. Given the importance of oxygen for cell and organism viability, mechanisms to sense and respond to hypoxia are in place. A variety of enzymes utilise molecular oxygen, but of particular importance to oxygen sensing are the 2-oxoglutarate (2-OG) dependent dioxygenases (2-OGDs). Of these, Prolyl-hydroxylases have long been recognised to control the levels and function of Hypoxia Inducible Factor (HIF), a master transcriptional regulator in hypoxia, via their hydroxylase activity. However, recent studies are revealing that dioxygenases are involved in almost all aspects of gene regulation, including chromatin organisation, transcription and translation. We highlight the relevance of HIF and 2-OGDs in the control of gene expression in response to hypoxia and their relevance to human biology and health.

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