Left Ventricular Systolic and Diastolic Function in Severe Obesity: A Radionuclide Study

Cardiology ◽  
1996 ◽  
Vol 87 (4) ◽  
pp. 347-353 ◽  
Author(s):  
Sergio Ferraro ◽  
Pasquale Perrone-Filardi ◽  
Alfonso Desiderio ◽  
Sandro Betocchi ◽  
Michele D’Alto ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Severe Obesity ◽  
Left Ventricular ◽  
Radionuclide Study ◽  
Systolic And Diastolic Function

Abstract 402: Vitamin C Deficiency Impairs Cardiac Function and Post-infarction Survival in the Mouse

2017 ◽  
Vol 121 (suppl_1) ◽  
Author(s):  
Adolfo G Mauro ◽  
Donatas Kraskauskas ◽  
Bassem M Mohammed ◽  
Bernard J Fisher ◽  
Eleonora Mezzaroma ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cardiac Function ◽  
Diastolic Function ◽  
Left Ventricular ◽  
Coronary Artery Ligation ◽  
Artery Ligation ◽  
Additional Group ◽  
Gulonolactone Oxidase ◽  
Low Levels ◽  
Systolic And Diastolic Function

Introduction: L-gulonolactone oxidase (Gulo) is the rate limiting enzyme for Vitamin C (VitC) biosynthesis. Humans rely on dietary VitC for collagen synthesis, extracellular matrix formation, and tissue regeneration. VitC deficiency is an unrecognized condition and its role in cardiac homeostasis and post-acute myocardial infarction (AMI) remodeling is unknown. Hypothesis: Low levels of VitC impair cardiac function and tissue repair following AMI. Methods: Adult male Gulo -/- knockout mice (C57BL6 background, N=8) and control C57BL (N=8), which are able to synthesize VitC were used. VitC deficiency was maintained supplying low levels of VitC (30mg/l) to Gulo -/- mice in drinking water. Mice underwent M-mode and Doppler echocardiography to measure left ventricular (LV) diameters and wall thicknesses, fractional shortening (FS), E and A waves, E/A ratio, isovolumetric relaxation time (IRT) and myocardial performance index (MPI). Experimental AMI was induced by coronary artery ligation for 7 days. An additional group of Gulo -/- were mice supplemented with physiological levels of VitC (330 mg/l) and underwent AMI. Results: VitC deficient Gulo -/- mice exhibited significantly reduced LV wall thicknesses, reduced FS, and impaired diastolic function, measured as significantly reduced E/A ratio and longer IRT (Panel A, B & C). Following AMI, 100% (8/8) of deficient Gulo -/- mice died within 5 days. Supplementation with physiological levels of VitC significantly improved survival after AMI (Panel D). Conclusion: VitC deficiency impairs systolic and diastolic function. Moreover, VitC is critical for the post-AMI survival.

scholarly journals Left ventricular systolic and diastolic function during orthostatic heat stress

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Michael D Nelson ◽  
Luis A Altamirano‐Diaz ◽  
Stewart R Petersen ◽  
Timothy P Just ◽  
Darren DeLorey ◽  
...  
Keyword(s):  
Heat Stress ◽  
Diastolic Function ◽  
Left Ventricular ◽  
Systolic And Diastolic Function
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