Amlodipine and the Total Ischemic Burden: Circadian Anti-Ischemia Program in Europe (CAPE) Trial – Methodology, Safety and Toleration

Cardiology ◽  
1994 ◽  
Vol 85 (2) ◽  
pp. 24-30
Author(s):  
Jean-Marie Detry
Keyword(s):  
Total Ischemic Burden

scholarly journals Serum Bilirubin Level Predicts Frontal QRS-T Angle Change in Patients with Acute Coronary Syndrome

2020 ◽  
Vol 6 (4) ◽  
pp. 75-83
Author(s):  
Güney Erdoğan ◽  
Mustafa Yenercağ ◽  
Gündüz Durmus ◽  
Diyar Koprulu ◽  
Uğur Arslan
Keyword(s):  
Acute Coronary Syndrome ◽  
Total Bilirubin ◽  
Serum Bilirubin ◽  
Multivariate Logistic Regression Analysis ◽  
Serum Bilirubin Level ◽  
Serum Total Bilirubin ◽  
Operating Characteristics ◽  
Coronary Syndrome ◽  
Angle Change ◽  
Total Ischemic Burden

AbstractIntroduction: The predictive role of serum bilirubin levels on the alteration of total ischemic burden expressed via frontal QRS-T angle change has never been studied in patients with acute coronary syndrome (ACS). In this study, we aimed to investigate the relationship between serum bilirubin levels and frontal QRS-T angle change after percutaneous coronary intervention (PCI) in ACS patients.Methods: Frontal QRS-T angle change was accepted as positive or negative according to whether the value of the baseline frontal QRS-T angle minus the post PCI frontal QRS-T angle is positive or negative. A total of 314 consecutive patients with ACS who underwent PCI were divided into two groups based on their negative frontal QRS-T angle change (n = 152 patients) and positive frontal QRS-T angle change (n = 162 patients).Results: Multivariate logistic regression analysis showed that the C-reactive protein (CRP) to albumin ratio (CAR) (Odds ratio [OR]: 0.519, 95% CI: 0.373–0.724, p <0.001), total bilirubin (OR: 3.687, 95% CI: 1.151–8.095, p = 0.03), and low-density lipoprotein (LDL) (OR: 0.985, 95% CI: 0.970–1.000, p = 0.04) were independent predictors of positive QRS-T angle change. In receiver operating characteristics curve analysis, a cut-off value of 0.59 total bilirubin had a 69% sensitivity and a 65% specificity (area under curve: 0.739, p <0.001) for the prediction of positive QRS-T angle change.Conclusion: In ACS patients, serum total bilirubin has been found to be a useful decision-making tool to predict positive frontal QRS-T angle change as a sign of reduced total ischemic burden, to assess early invasive strategy independently from other study parameters.

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