Mechanisms of Pancreatic Hypersecretion following Intraduodenal Hyperosmolar Glucose Infusion in Rats

1983 ◽  
Vol 27 (4) ◽  
pp. 338-344
Author(s):  
J. Chariot ◽  
C. Roze ◽  
J.A. Chayvialle
Keyword(s):  
Glucose Infusion ◽  
Hyperosmolar Glucose

Intestinal responses to hyperosmolar glucose infusion in dogs

1977 ◽  
Vol 12 (2) ◽  
pp. 30-38 ◽  
Author(s):  
Tsuneo Fukushima ◽  
Naoki Ishiguro ◽  
Fumihiko Kito ◽  
Takashi Suda ◽  
Toshihiko Yamagishi ◽  
...  
Keyword(s):  
Glucose Infusion ◽  
Hyperosmolar Glucose

Plasma hyperosmolality stimulates leptin secretion acutely by a vasopressin-adrenal mechanism

2004 ◽  
Vol 287 (2) ◽  
pp. E263-E268 ◽  
Author(s):  
James R. Levy ◽  
Wayne Stevens
Keyword(s):  
Sodium Chloride ◽  
Peak Plasma ◽  
Glucose Infusion ◽  
Hypertonic Solution ◽  
Dependent Manner ◽  
Glucose Administration ◽  
Hypertonic Glucose ◽  
Plasma Leptin ◽  
Dose Dependent ◽  
Hyperosmolar Glucose

Glucose administration to rodents acutely stimulates leptin secretion. To investigate the mechanism, rats were infused intravenously with various concentrations of glucose, and plasma leptin concentrations were measured with time. The osmolality of the infusates was equalized with various concentrations of carbohydrates that are not metabolized. Hyperosmolar glucose stimulates leptin secretion in a dose-dependent manner, with peak plasma leptin concentrations occurring ∼3 h after the end of the glucose infusion. Hypertonic infusions of galactose, mannitol, and sodium chloride independently stimulate leptin secretion with approximately one-half the strength of equivalent osmolar concentrations of glucose. Peak plasma leptin concentrations occur ∼4 h after the end of the hypertonic solution infusion. Hypertonic solutions of mannitol do not stimulate leptin secretion in vasopressin-deficient or in adrenalectomized animals. In conclusion, intravenous infusions of hypertonic glucose and hypertonic mannitol independently stimulate leptin secretion. Hyperosmolality stimulates leptin secretion by a vasopressin-adrenal mechanism.

Serum insulin response to slow-rise glucose infusion in "genetic prediabetics" (offspring of two diabetic parents)

Diabetes ◽  
1977 ◽  
Vol 26 (5) ◽  
pp. 490-499 ◽  
Author(s):  
M. H. Tan ◽  
R. F. Williams ◽  
J. S. Soeldner ◽  
R. E. Gleason
Keyword(s):  
Serum Insulin ◽  
Insulin Response ◽  
Glucose Infusion ◽  
Slow Rise

Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion

Diabetes ◽  
1989 ◽  
Vol 38 (1) ◽  
pp. 49-53 ◽  
Author(s):  
S. Bonner-Weir ◽  
D. Deery ◽  
J. L. Leahy ◽  
G. C. Weir
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Compensatory Growth ◽  
Glucose Infusion ◽  
Short Term ◽  
Adult Rats

scholarly journals Arterial concentration and forearm extraction of glucose and insulin during the early phase of a glucose infusion

Diabetologia ◽  
1976 ◽  
Vol 12 (6) ◽  
pp. 589-592 ◽  
Author(s):  
G. Riccardi ◽  
D. Heaf ◽  
L. Kaijser ◽  
B. Eklund ◽  
L. A. Carlson
Keyword(s):  
Early Phase ◽  
Glucose Infusion ◽  
Arterial Concentration

scholarly journals Inaccuracy in automated measurement of hematocrit and corpuscular indices in the presence of severe hyperglycemia

Blood ◽  
1981 ◽  
Vol 57 (6) ◽  
pp. 1065-1067 ◽  
Author(s):  
JA Strauchen ◽  
W Alston ◽  
J Anderson ◽  
Z Gustafson ◽  
LF Fajardo
Keyword(s):  
Blood Glucose ◽  
Mean Corpuscular Volume ◽  
Hemoglobin Concentration ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Volume ◽  
Automated Measurement ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Hyperosmolar Glucose

Abstract Because we recently observed two patients with severe diabetic hyperglycemia and spuriously elevated electronically determined hematocrit and mean corpuscular volume (MCV), we investigated the effect of hyperglycemia on two popular automated hematology systems, the Coulter S and Ortho ELT-8. Marked hyperglycemia (blood glucose 800-- 2000 mg/dl) caused consistent overestimation of the electronically determined MCV compared to that derived from a simultaneous spun microhematocrit. The resultant overestimation and underestimation, respectively, of the derived values for hematocrit and mean corpuscular hemoglobin concentration may be clinically misleading. The mechanism of MCV elevation in hyperglycemia appears to be swelling of hyperosmolar glucose “loaded” erythrocytes when diluted into “isotonic” counting medium. This effect is readily circumvented by determination of a spun microhematocrit.

PRE-DIALYSIS APPLICATION OF THE GLUCOSE INFUSION TEST FOR RECIRCULATION DETECTION

2005 ◽  
Vol 31 (4) ◽  
pp. 191-193
Author(s):  
C. Libori ◽  
M. Spallazzi ◽  
M. Bono ◽  
C. Brozzo ◽  
M. Celsi ◽  
...  
Keyword(s):  
Glucose Infusion ◽  
Infusion Test ◽  
Glucose Infusion Test
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