Role of Dietary Intervention in the Primary Prevention of Coronary Heart Disease

Cardiology ◽  
1987 ◽  
Vol 74 (1) ◽  
pp. 2-21 ◽  
Author(s):  
Conrad B. Blum ◽  
Robert I. Levy
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Primary Prevention ◽  
Dietary Intervention

Lycopene, Tomatoes, and the Prevention of Coronary Heart Disease

2002 ◽  
Vol 227 (10) ◽  
pp. 908-913 ◽  
Author(s):  
A. V. Rao
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Dietary Intervention ◽  
Antioxidant Properties ◽  
Ldl Oxidation ◽  
Western World ◽  
Principal Mechanism ◽  
Myocardial Infraction

Coronary heart disease (CHD) is one of the primary causes of death in the Western world. The emphasis so far has been on the relationship between serum cholesterol levels and the risk of CHD. More recently, oxidative stress induced by reactive oxygen species (ROS) is also considered to play an important part in the etiology of this disease. Oxidation of the circulating low-density lipoprotein (LDLox) is thought to play a key role in the pathogenesis of atherosclerosis and CHD. According to this hypothesis, macrophages inside the arterial wall take up the LDLox and initiate the process of plaque formation. Dietary antioxidants such as vitamin E and ß-carotene have been shown in In vitro studies to prevent the formation of LDLox and their uptake by microphages. In a recent study, healthy human subjects ingesting lycopene, a carotenoid antioxidant, in the form of tomato juice, tomato sauce, and oleoresin soft gel capsules for 1 week had significantly lower levels of LDLox compared with controls. The antioxidant effects of lycopene have also been shown in four other human trials, including one where lycopene consumption reduced the levels of breath pentane. However, in one recent study, dietary supplementation with ß-carotene but not with lycopene was shown to inhibit LDL oxidation. The sources of lycopene used in most of these studies were either tomato products or lycopene extracted from tomatoes containing other carotenoids in various proportions. Therefore, it is not possible to attribute the effects solely to lycopene. Mechanisms other than the antioxidant properties of lycopene have also been shown to reduce the risk of CHD. Lycopene was shown to inhibit the activity of an essential enzyme involved in cholesterol synthesis in an in vitro and a small clinical study suggesting a hypocholesterolemic effect. Other possible mechanisms include enhanced LDL degradation, LDL particle size and composition, plaque rupture, and altered endothelial functions. Recent epidemiological studies have also shown an inverse relationship between tissue and serum levels of lycopene and mortality from CHD, cerebrovascular disease, and myocardial infraction. However, the most impressive population-based evidence comes from a multicenter case-control study where subjects from 10 European countries were evaluated for relationship between antioxidant status and acute myocardial infarctions. After adjusting for a range of dietary variables, only lycopene levels but not ß-carotene were found to be protective. At present, the role of lycopene in the prevention of CHD is strongly suggestive. Although the antioxidant property of lycopene may be one of the principal mechanism for its effect, other mechanisms may also be responsible. Controlled clinical and dietary intervention studies using well-defined subject populations and disease end points must be undertaken in the future to provide definitive evidence for the role of lycopene in the prevention of CHD. Mechanistic studies must also be initiated to understand the mode of lycopene action.

Modern ideas about the role of hyperuricemia in the pathogenesis of coronary heart disease

2018 ◽  
Vol 2 (1) ◽  
pp. 47-54
Author(s):  
Eleonora TASHKENBAEVA ◽  
◽  
Dilshod TOGAEV ◽  
Farzona KADIROVA ◽  
Shukhrat ZIYADULLAEV ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease

The Role of Mapalus Culture by Minahasa Ethnic in North Sulawesi to the Coronary Heart Disease Incidents

2018 ◽  
Vol 8 (3) ◽  
Author(s):  
Jeini Ester Nelwan ◽  
Edi Widjajanto ◽  
Sri Andarini ◽  
Sasmito Djati ◽  
Oksfriani Jufri Sumampouw
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
North Sulawesi

Plasma antioxidative activity during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention

2004 ◽  
Vol 18 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Jan Kowalski ◽  
Lucjan Pawlicki ◽  
Joanna Grycewicz ◽  
Jan Blaszczyk ◽  
Robert Irzmanski ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Primary Prevention ◽  
Antioxidative Activity
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