An Overview of Slow Channel Blocking Drugs: Pharmacological Basis for Therapeutic Applications

Cardiology ◽  
1982 ◽  
Vol 69 (1) ◽  
pp. 2-25 ◽  
Author(s):  
B.N. Singh
Keyword(s):  
Therapeutic Applications ◽  
Slow Channel ◽  
Channel Blocking ◽  
Pharmacological Basis

Interaction between calcium and slow channel blocking drugs on atrial rate

1983 ◽  
Vol 322 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Mar�a Cristina Camili�n de Hurtado ◽  
Horacio Eugenio Cingolani
Keyword(s):  
Atrial Rate ◽  
Slow Channel ◽  
Channel Blocking

Electrophysiologic and hemodynamic effects of slow-channel blocking drugs

1982 ◽  
Vol 25 (2) ◽  
pp. 103-132 ◽  
Author(s):  
Bramah N. Singh ◽  
Harvey S. Hecht ◽  
Koonlawee Nademanee ◽  
Christopher Y.C. Chew
Keyword(s):  
Hemodynamic Effects ◽  
Slow Channel ◽  
Channel Blocking

scholarly journals Pharmacological basis for the medicinal use of Viola odorata in diarrhea, bronchial asthma and hypertension

2015 ◽  
Vol 10 (4) ◽  
pp. 836 ◽  
Author(s):  
Khalid Hussain Janbaz ◽  
Waseem Ullah Khan ◽  
Fatima Saqib ◽  
Mamoona Khalid
Keyword(s):  
Channel Blocker ◽  
Response Curves ◽  
Relaxant Effect ◽  
Viola Odorata ◽  
Medicinal Use ◽  
Channel Blocking ◽  
Blocking Activity ◽  
Rabbit Jejunum ◽  
Spontaneous Contractions ◽  
Pharmacological Basis

<p class="Abstract"><em>Viola odorata</em> is traditionally used in the management of gastrointestinal,  respiratory and vascular disorders. The present study was undertaken to validate its folkloric uses. The application of <em>V. odorata</em> to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions. Moreover, it also caused relaxation of K<sup>+ </sup>(80 mM)-induced contractions and shifted the Ca<sup>2+ </sup>concentration response curves toward right in isolated jejunum similar to verapamil (standard Ca<sup>2+ </sup>channel blocker), confirming Ca<sup>2+ </sup>channel blocking activity. <em>V. odorata</em> also caused relaxation of carbachol (1 µM)- and K<sup>+ </sup>(80 mM)-induced contractions in isolated rabbit tracheal preparations comparable to verapamil, reflecting that observed relaxant effect may be the outcome of anti-muscarinic and/or Ca<sup>2+ </sup>channel blocking activities. It also exerted relaxant effect on phenylephrine (1 µM)- and K<sup>+ </sup>(80 mM)-induced contractions in isolated rabbit aortic preparations thus providing rationale for  its folkloric  uses to treat diarrhea, asthma and hypertension.</p>

Clinical applications of slow channel blocking compounds

1983 ◽  
Vol 23 (1) ◽  
pp. 1-43 ◽  
Author(s):  
A. Gray Ellrodt ◽  
Bramah N. Singh
Keyword(s):  
Clinical Applications ◽  
Slow Channel ◽  
Channel Blocking
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