Age-Related Changes in Rat Glomerular Basement Membrane Components Solubilised with Pepsin

1985 ◽  
Vol 8 (2) ◽  
pp. 120-128
Author(s):  
Farhad Khalil-Manesh ◽  
Robert G. Price
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Age Related ◽  
Membrane Components ◽  
Age Related Changes ◽  
Basement Membrane Components

scholarly journals Relationship Between Immunoglobulin Deposition and Early Lesions of Progressive Glomerulonephropathy in Young Common Marmosets

2017 ◽  
Vol 55 (1) ◽  
pp. 173-176 ◽  
Author(s):  
Naoaki Yamada ◽  
Nanako Hashimoto ◽  
Junichi Kamiie ◽  
Takuya Doi ◽  
Junko Sato ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Ultrastructural Changes ◽  
Common Marmosets ◽  
Early Lesions ◽  
Age Related ◽  
Tubulointerstitial Lesions ◽  
Glomerular Lesions ◽  
Foot Process ◽  
Age Related Changes

The authors previously investigated progressive glomerulonephropathy in 2- to 11-year-old common marmosets and characterized age-related changes of the renal glomeruli and development of tubulointerstitial lesions. In this study, immunoglobulin deposition and ultrastructural changes of the glomeruli were investigated in 5 young marmosets from 6 months to 3 years of age with pre-onset or early glomerulonephropathy. In all animals, the foot processes of podocytes were effaced, and IgM was deposited into the glomeruli. In glomeruli without glomerular basement membrane (GBM) alteration, IgM was the only immunoglobulin type deposited in the glomeruli. In cases with more advanced lesions of reticulation and thickening of GBM, IgA and IgG deposits were also observed. Therefore, the authors conclude that IgM may be the primary or earliest immunoglobulin deposited in this nephropathy, whereas IgA and IgG deposition may be connected to the progression of the glomerular lesions. IgM deposition and foot process effacement of podocytes occur early in the life of affected marmosets.

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