Expression of Plasma Renin Activity in Terms of Urinary Sodium Excretion and Posture in Normal Subjects on Free Sodium Intake

1984 ◽  
Vol 7 (4) ◽  
pp. 237-242
Author(s):  
J.P. Wolf ◽  
M.T. Henriet ◽  
N.U. Nguyen ◽  
G. Dumoulin ◽  
M. Laroze ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Sodium Excretion ◽  
Sodium Intake ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
Renin Activity

Plasma Renin, Urinary Sodium Excretion and Vascular Disease

1974 ◽  
Vol 48 (s2) ◽  
pp. 127s-129s
Author(s):  
A. E. Doyle ◽  
K. G. Chua ◽  
S. Duffy ◽  
W. J. Louis
Keyword(s):  
Plasma Renin Activity ◽  
Urinary Excretion ◽  
Vascular Disease ◽  
Sodium Excretion ◽  
Mild Hypertension ◽  
Sodium Intake ◽  
Plasma Renin ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
Renin Activity

1. Urinary sodium excretion and plasma renin activity have been measured in a group of persons with untreated mild hypertension and in a control normotensive group. 2. Preliminary analyses of the data indicate that the daily sodium excretion was significantly higher in the hypertensive group but the plasma renin activity did not correlate significantly with the urinary excretion of sodium. 3. These findings suggest that sodium intake was significantly greater in a population with mild hypertension than in a comparable normotensive group.

Acute effect of a thromboxane synthetase inhibitor on renal function in unanaesthetized sheep

1987 ◽  
Vol 73 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Allan D. Cumming ◽  
Robert M. Lindsay ◽  
J. W. D. McDonald ◽  
Adam L. Linton
Keyword(s):  
Plasma Renin Activity ◽  
Sodium Excretion ◽  
Urine Volume ◽  
Plasma Renin ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
Renin Activity ◽  
Synthetase Inhibitor ◽  
Fractional Sodium Excretion ◽  
Thromboxane Synthetase

1. Eleven healthy, unanaesthetized sheep were given either a single intravenous bolus infusion of U63,577A (Upjohn), a selective thromboxane synthetase inhibitor, at a dose of 30 mg/kg (group 1, n = 6), or vehicle alone (group 2, n = 5). Animals were maintained in metabolic cages during the study, and received 150 ml of water/h and 7.5 mmol of sodium/h as Ringers lactate by intravenous infusion for 24 h before and during the study. During two 1 h control urine collections via bladder catheter, urine volume and sodium excretion closely paralleled these infusion rates. 2. In the first hour after injection of U63,577A, there were significant two- to three-fold increases in urine volume, urinary sodium excretion and fractional sodium excretion, compared with the control collections. During the subsequent 4 h, urine volume, urinary sodium excretion, and fractional sodium excretion fell to values significantly lower than in the control period. Creatinine clearance was reduced 1, 2 and 4 h post injection and returned to control values at 5 h. Urinary excretion of thromboxane B2 was significantly reduced compared with control values during the 5 h after injection of U63,577A. Excretion of 6-keto-prostaglandin F1α did not change. Plasma renin activity was significantly increased 1, 3 and 5 h after injection of U63,577A. Vehicle controls showed no change in any of the above parameters. 3. The results indicate that in healthy conscious sheep, sodium and water replete, U63,577A has a transient but significant diuretic and natriuretic effect, followed by sodium and water retention and increased plasma renin activity. The results may reflect an antidiuretic/antinatriuretic effect of thromboxane A2, or possibly diversion of cyclic endoperoxides into formation of vasodilator/natriuretic prostaglandins. These effects might be exaggerated and/or modified in conditions where arachidonic acid metabolism is stimulated.

Influence of Age and Sodium Intake on Plasma Renin Activity of Normal Subjects

Nephron ◽  
1980 ◽  
Vol 26 (4) ◽  
pp. 189-194 ◽  
Author(s):  
S. Salvetti ◽  
R. Pedrinelli ◽  
A. Magagna ◽  
L. Poli ◽  
P. Sassano ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Sodium Intake ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Renin Activity

Biochemical Correlates of the Increase in Blood Pressure with Age

1978 ◽  
Vol 55 (s4) ◽  
pp. 377s-379s ◽  
Author(s):  
C. E. Grim ◽  
M. H. Weinberger ◽  
D. P. Henry ◽  
F. C. Luft ◽  
N. S. Fineberg
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Sodium Intake ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Renin Activity ◽  
Multiple Correlation Analysis ◽  
Normotensive Subjects ◽  
Relationship Of ◽  
The Relationship

1. Blood pressure, plasma renin activity, plasma aldosterone, urinary noradrenaline during sleep (UNA-S) and several estimates of sodium intake were determined in 379 normotensive subjects (age 13–70) to investigate the relationship of these variables to blood pressure. 2. Blood pressure was correlated with age, weight, plasma renin activity UNA-S, and estimates of sodium intake. These variables were frequently intercorrelated. 3. Multiple-correlation analysis revealed that after removal of the effects of age, blood pressure was related to weight, plasma renin activity, UNA-S and estimates of sodium intake. 4. However, multiple-regression analysis failed to demonstrate an effect of plasma renin activity, UNA-S, or estimates of sodium intake on blood pressure when the effects of age, weight, race and sex were removed. 5. Careful matching of subjects by age, weight, race and sex in studies of blood pressure and biochemical factors in normal subjects is crucial to proper interpretation of such data.

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