The Effects of Nitric Oxide Donor Molsidomine on Skeletal Muscle Damage in a Rat Hind Limb Model of Ischemia-Reperfusion

2008 ◽  
Vol 42 (2) ◽  
pp. 71-77 ◽  
Author(s):  
K. Öztürk ◽  
H. Ozyurt ◽  
A. Somay ◽  
C. Karaca
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Muscle Damage ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Nitric Oxide Donor ◽  
Skeletal Muscle Damage

Effect of Ischemia and Reperfusion on Skeletal Muscle Damage

2010 ◽  
Author(s):  
Sandra Loerakker ◽  
Emmy Manders ◽  
Gustav J. Strijkers ◽  
Frank P. T. Baaijens ◽  
Dan L. Bader ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Soft Tissues ◽  
Ischemia Reperfusion Injury ◽  
Tissue Injury ◽  
Ischemia Reperfusion ◽  
Ischemia And Reperfusion ◽  
Skin Damage ◽  
Deep Tissue ◽  
Skeletal Muscle Damage

Sustained mechanical loading of soft tissues covering bony prominences, as experienced by bedridden and wheelchair-bound individuals, may cause skeletal muscle damage. This can result in a condition termed pressure-related deep tissue injury (DTI), a severe kind of pressure ulcer that initiates in deep tissue layers, and progresses towards the skin. Damage pathways leading to DTI can involve ischemia, ischemia/reperfusion injury, impaired lymphatic drainage, and sustained tissue deformation. Recently, we have provided evidence that in a controlled animal model, deformation is the main trigger for damage within a 2h loading period [1,2]. However, ischemia and reperfusion may play a more important role in the damage process during prolonged loading periods.

Effect of Continuous and Intermittent Mechanical Loading on the Development of Skeletal Muscle Damage - A Combined Experimental/Numerical Approach

2009 ◽  
Author(s):  
Sandra Loerakker ◽  
Anke Stekelenburg ◽  
Gustav J. Strijkers ◽  
Klaas Nicolay ◽  
Dan L. Bader ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Mechanical Loading ◽  
Soft Tissues ◽  
Tissue Injury ◽  
Ischemia Reperfusion ◽  
Clear Correlation ◽  
Tissue Deformation ◽  
Deep Tissue ◽  
Skeletal Muscle Damage

Prolonged mechanical loading of soft tissues, as present when individuals are bedridden or wheelchair-bound, can lead to degeneration of skeletal muscle tissue. This can result in a condition termed pressure-related deep tissue injury (DTI), a severe kind of pressure ulcer that initiates in deep tissue layers, e.g. skeletal muscle, near bony prominences and progresses towards the skin. Complications associated with DTI include sepsis, renal failure, and myocardial infarction. Damage pathways leading to DTI involve ischemia, ischemia-reperfusion injury, impaired lymphatic drainage, and sustained tissue deformation. Recently, the role of tissue deformation in the onset of skeletal muscle damage was established by combining animal experiments with finite element (FE) modeling [1]. After 2 hours of continuous loading, a clear correlation between maximum shear strain and damage was found.

scholarly journals Cryotherapy reduces skeletal muscle damage after ischemia/reperfusion in rats

2012 ◽  
Vol 222 (2) ◽  
pp. 223-230 ◽  
Author(s):  
Gustavo O. Puntel ◽  
Nélson R. Carvalho ◽  
Fernando Dobrachinski ◽  
Andréia C. F. Salgueiro ◽  
Robson L. Puntel ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Ischemia Reperfusion ◽  
Skeletal Muscle Damage

Cardiorespiratory and skeletal muscle damage due to COVID-19: making the urgent case for rehabilitation

2021 ◽  
pp. 1-14
Author(s):  
Rebeca Nunes Silva ◽  
Cássia Da Luz Goulart ◽  
Murilo Rezende Oliveira ◽  
Guilherme Yassuyuki Tacao ◽  
Guilherme Dionir Back ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Skeletal Muscle Damage ◽  
Urgent Case

Modifications in the Concentrations of Circulating Myoglobin after Treatment with Low Doses of Adriamycin

1985 ◽  
Vol 71 (5) ◽  
pp. 463-468 ◽  
Author(s):  
Giovanni Carulli ◽  
Aldo Clerico ◽  
Alessandra Marini ◽  
Maria Grazia Del Chicca ◽  
Renato Vanacore ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Cancer Patients ◽  
Muscle Damage ◽  
Low Doses ◽  
Skeletal Muscle Damage ◽  
Creatine Kinase Mb

The modifications in the concentration of circulating myoglobin have been studied by means of a radioimmunoassay in 15 cancer patients undergoing polychemotherapy including adriamycin. In 8 patients significant increases in myoglobin levels were found after injection of low doses of the drug (25-50 mg/m2). Moreover, a disturbance of the normal biorhythm of the protein was evident in 12 patients. Creatine kinase-MB was evaluated by means of a radioimmunoassay, but there was no relation between an increase in the isoenzyme and an increase in myoglobin. No ECG modifications were detected. These data indicate that the measurement of myoglobin may offer an indication of myocardial or skeletal muscle damage caused by adriamycin.

Isoform specific ALT measurement during liver and skeletal muscle damage

2012 ◽  
Vol 211 ◽  
pp. S48
Author(s):  
Björn Glinghammar ◽  
Ingalill Rafter ◽  
Ina Schuppe-Koistinen ◽  
Ian Cotgreave
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Skeletal Muscle Damage

The effect of the nitric oxide donor sodium nitroprusside on glucose uptake in human primary skeletal muscle cells

Nitric Oxide ◽  
2009 ◽  
Vol 21 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Darren C. Henstridge ◽  
Brian G. Drew ◽  
Melissa F. Formosa ◽  
Alaina K. Natoli ◽  
David Cameron-Smith ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Sodium Nitroprusside ◽  
Glucose Uptake ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Nitric Oxide Donor
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