Extrarenal Potassium Adaptation: Review of a Concept

1995 ◽  
Vol 15 (5) ◽  
pp. 367-373 ◽  
Author(s):  
Aaron Spital ◽  
Richard H. Sterns
Keyword(s):  
Potassium Adaptation

Haematological influences of potassium adaptation in normotensive and renally-hypertensive Wistar rats

2002 ◽  
Vol 59 (2) ◽  
pp. 80-84
Author(s):  
R.I. Ozolua ◽  
E.K.I. Omogbai ◽  
A.B. Famodu ◽  
A.B. Ebeigbe ◽  
O.I. Ajayi
Keyword(s):  
Wistar Rats ◽  
Potassium Adaptation

scholarly journals Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule

1984 ◽  
Vol 26 (6) ◽  
pp. 798-807 ◽  
Author(s):  
David Hirsch ◽  
Michael Kashgarian ◽  
Emile L. Boulpaep ◽  
John P. Hayslett
Keyword(s):  
Potassium Adaptation ◽  
Collecting Tubule

Potassium adaptation in hypothyroidism: changes in transport adenosinetriphosphatases

1993 ◽  
Vol 264 (1) ◽  
pp. F31-F36 ◽  
Author(s):  
M. M. Salem ◽  
Y. Chen ◽  
S. K. Mujais
Keyword(s):  
Morphological Changes ◽  
Thick Ascending Limb ◽  
Adaptive Responses ◽  
Medullary Thick Ascending Limb ◽  
Potassium Adaptation ◽  
Adenosine Triphosphatases ◽  
Collecting Tubule ◽  
Pump Activity ◽  
Major Increase ◽  
K Depletion

To evaluate whether hypothyroidism alters the adaptive responses of renal transport adenosine-triphosphatases (ATPases) to modifications in dietary K content, we examined the activities of Na-K pump and H-K pump in hypothyroid rats under basal conditions and after dietary K changes. Hypothyroidism led to a decline in Na-K pump activity in all three nephron segments examined [proximal convoluted tubule from 2,333 +/- 103 to 1,099 +/- 32, medullary thick ascending limb from 4,344 +/- 119 to 1,613 +/- 61, and cortical collecting tubule (CCT) from 1,133 +/- 45 to 640 +/- 38 pmol.mm-1 x h-1; all P < 0.01 vs. euthyroid] along with morphological changes manifest in a decrease in tubule diameter. K loading led to an increase in Na-K pump activity in the CCT of both euthyroid (from 1,133 +/- 45 to 2,269 +/- 74, pmol.mm-1 x h-1, P < 0.01) and hypothyroid (from 640 +/- 38 to 1,118 +/- 67 pmol.mm-1 x h-1, P < 0.01) animals. Furthermore, in euthyroid rats, 3 wk of K depletion led to a major increase in H-K pump activity in both the CCT (from 203 +/- 14 to 331 +/- 22 pmol.mm-1 x h-1, P < 0.01) and medullary collecting tubule (MCT, from 137 +/- 9 to 210 +/- 14 pmol.mm-1 x h-1, P < 0.01). Hypothyroidism was associated with a decline in H-K pump activity in the CCT and MCT (to 94 +/- 6 and 55 +/- 5 pmol.mm-1 x h-1, respectively; both P < 0.01 vs. euthyroid).(ABSTRACT TRUNCATED AT 250 WORDS)

Renal memory after potassium adaptation: role of Na+-K+-ATPase

1988 ◽  
Vol 254 (6) ◽  
pp. F845-F850 ◽  
Author(s):  
S. K. Mujais
Keyword(s):  
Atpase Activity ◽  
Time Course ◽  
Base Line ◽  
Sprague Dawley ◽  
Membrane Transport Proteins ◽  
Sprague Dawley Rats ◽  
Potassium Adaptation ◽  
Collecting Tubule ◽  
Cortical Collecting Tubule

The present study was designed to explore the time course of the resolution of enhanced Na+-K+-ATPase activity in the cortical collecting tubule (CCT) and the parallel changes in renal K excretion that are characteristic of potassium adaptation. Potassium-adapted male Sprague-Dawley rats manifested an enhanced kaliuretic response to an acute intravenous load of KCl and a doubling of Na+-K+-ATPase activity in the CCT. Withdrawal of dietary K loading from these adapted rats was associated with a gradual resolution of these adaptive biochemical (t1/2 of Na+-K+-ATPase return to base line 48 h) and excretory changes. During this resolution phase, however, a temporal discrepancy was uncovered between the change in dietary K and the slower changes in enzyme activity and renal K excretion with a persistence of the enhanced kaliuresis leading to a negative K balance. We conclude that the slow inactivation, after withdrawal of K loading, of the increased membrane transport proteins of K adaptation, will manifest as a renal memory of the antecedent excretory requirements.

Aldosterone secretion and the mechanism of potassium adaptation in rats

Steroids ◽  
1993 ◽  
Vol 58 (7) ◽  
pp. 305-313 ◽  
Author(s):  
Richard D. McCabe ◽  
Manis J. Smith ◽  
Terry M. Dwyer
Keyword(s):  
Aldosterone Secretion ◽  
Potassium Adaptation

scholarly journals Changes in membrane surfaces of collecting duct cells in potassium adaptation

1980 ◽  
Vol 18 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Asghar Rastegar ◽  
Daniel Biemesderfer ◽  
Michael Kashgarian ◽  
John P. Hayslett ◽  
Dr M Kashgarian
Keyword(s):  
Collecting Duct ◽  
Membrane Surfaces ◽  
Duct Cells ◽  
Potassium Adaptation ◽  
Collecting Duct Cells
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