Escape of Red Blood Cells through Gaps in Glomerular Basement Membrane in a Patient with Mixed Connective Tissue Disease

1995 ◽  
Vol 15 (2) ◽  
pp. 168-171 ◽  
Author(s):  
Hirofumi Makino ◽  
Isao Kumagai ◽  
Kazue Hironaka ◽  
Kosuke Ota ◽  
Kenichi Shikata ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Basement Membrane ◽  
Red Blood Cells ◽  
Connective Tissue Disease ◽  
Glomerular Basement Membrane ◽  
Blood Cells ◽  
Mixed Connective Tissue Disease

Importance of mechanical damage to urinary red blood cells by the glomerular basement membrane

1994 ◽  
Vol 36 (6) ◽  
pp. 656-657 ◽  
Author(s):  
YUKIHIRO ISHIHARA ◽  
MIYAKO MORITA ◽  
TAKESHI MATSUYAMA ◽  
MASAHIRO IKEDA ◽  
KUZUHIKO KAWAHARA ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Red Blood Cells ◽  
Glomerular Basement Membrane ◽  
Blood Cells ◽  
Mechanical Damage

Genetic inactivation of the laminin α5chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse

2008 ◽  
Vol 294 (2) ◽  
pp. F393-F406 ◽  
Author(s):  
Cécile Rahuel ◽  
Anne Filipe ◽  
Léa Ritie ◽  
Wassim El Nemer ◽  
Natacha Patey-Mariaud ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Basement Membrane ◽  
Red Blood Cells ◽  
Glomerular Basement Membrane ◽  
Blood Cells ◽  
Laminin Receptor ◽  
Limited Information ◽  
Wild Type ◽  
Muscle Coat

Lutheran blood group and basal cell adhesion molecule (Lu/BCAM) has been recognized as a unique receptor for laminin α5chain in human red blood cells and as a coreceptor in epithelial, endothelial, and smooth muscle cells. Because limited information is available regarding the function of this adhesion glycoprotein in vivo, we generated Lu/BCAM-null mice and looked for abnormalities in red blood cells as well as in kidney and intestine, two tissues showing alteration in laminin α5chain-deficient mice. We first showed that, in contrast to humans, wild-type murine red blood cells failed to express Lu/BCAM. Lu/BCAM-null mice were healthy and developed normally. However, although no alteration of the renal function was evidenced, up to 90% of the glomeruli from mutant kidneys exhibited abnormalities characterized by a reduced number of visible capillary lumens and irregular thickening of the glomerular basement membrane. Similarly, intestine analysis of mutant mice revealed smooth muscle coat thickening and disorganization. Because glomerular basement membrane and smooth muscle coat express laminin α5chain and are in contact with cell types expressing Lu/BCAM in wild-type mice, these results provide evidence that Lu/BCAM, as a laminin receptor, is involved in vivo in the maintenance of normal basement membrane organization in the kidney and intestine.

scholarly journals AB1138 High levels of anti-u1rnp and anti-sm in mixed connective tissue disease patients

2018 ◽  
Author(s):  
E. Grau Garcia ◽  
P. Jover Carbonell ◽  
I. Martinez Cordellat ◽  
R. Negueroles Albuixech ◽  
J.E. Oller Rodriguez ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease

MIXED CONNECTIVE TISSUE DISEASE IN CHILDREN

Rheumatology ◽  
1978 ◽  
Vol 17 (4) ◽  
pp. 245-248 ◽  
Author(s):  
S. A. PESKETT ◽  
B. M. ANSELL ◽  
P. FIZZMAN ◽  
A. HOWARD
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease
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