Autosomal Dominant Polycystic Kidney Disease Complicated by Primary Aldosteronism

1994 ◽  
Vol 14 (3) ◽  
pp. 236-238 ◽  
Author(s):  
Fumitake Gejyo ◽  
Kiichiro Ishida ◽  
Masaaki Arakawa
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Primary Aldosteronism ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney

scholarly journals Tolvaptan for Primary Aldosteronism and Autosomal Dominant Polycystic Kidney Disease: A Case Report

2018 ◽  
Vol 8 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Kyohei Kunizawa ◽  
Junichi Hoshino ◽  
Hiroki Mizuno ◽  
Tatsuya Suwabe ◽  
Keiichi Sumida ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Muscle Weakness ◽  
Primary Aldosteronism ◽  
Autosomal Dominant ◽  
Japanese Woman ◽  
High Dose ◽  
Polycystic Kidney ◽  
Old Japanese ◽  
Autosomal Dominant Polycystic Kidney

A 59-year-old Japanese woman was admitted for evaluation of muscle weakness. Autosomal dominant polycystic kidney disease had been diagnosed at the age of 47 years, followed by primary aldosteronism at 53 years. At the age of 58, tolvaptan was started (60 mg/day) to treat her renal disease. After 8 months of tolvaptan therapy, hypokalemia-related muscle weakness became prominent, and hypertension became refractory. Finally, treatment with low-dose tolvaptan (30 mg/day) and high-dose spironolactone (100 mg/day) normalized serum potassium and the blood pressure. Tolvaptan can induce urinary excretion of potassium in patients with primary aldosteronism, and possible mechanisms are discussed.

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