Beta-2-Microglobulin Amyloidosis in Long-Term Dialysis Patients

1989 ◽  
Vol 9 (3) ◽  
pp. 177-183 ◽  
Author(s):  
William J. Stone ◽  
Raymond M. Hakim
Keyword(s):  
Dialysis Patients ◽  
Beta 2 ◽  
Beta 2 Microglobulin

scholarly journals The unresolved problem of beta-2 microglobulin amyloid deposits in the intervertebral discs of long-term dialysis patients

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Tsung-Ting Tsai ◽  
Arun-Kumar Kaliya-Perumal ◽  
Chang-Chyi Jenq ◽  
Chi-Chien Niu ◽  
Natalie Yi-Ju Ho ◽  
...  
Keyword(s):  
Intervertebral Discs ◽  
Dialysis Patients ◽  
Unresolved Problem ◽  
Amyloid Deposits ◽  
Beta 2 ◽  
Beta 2 Microglobulin

scholarly journals Systemic amyloidosis of beta 2-microglobulin type: a complication of long-term haemodialysis.

1987 ◽  
Vol 40 (10) ◽  
pp. 1247-1251 ◽  
Author(s):  
J M Theaker ◽  
A E Raine ◽  
A J Rainey ◽  
A Heryet ◽  
A Clark ◽  
...  
Keyword(s):  
Type A ◽  
Systemic Amyloidosis ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Beta 2-Microglobulin Synthesis of Mononuclear Cells in Chronic Dialysis Patients

1992 ◽  
Vol 15 (7) ◽  
pp. 401-407 ◽  
Author(s):  
K. Kumano ◽  
M. Nanbu ◽  
S. Kusakari ◽  
T. Sakai
Keyword(s):  
Healthy Volunteers ◽  
Mononuclear Cells ◽  
Cultured Cells ◽  
Dialysis Patients ◽  
Amyloid Deposits ◽  
Cell Mediated Immune Response ◽  
Before And After ◽  
Dialysis Membranes ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Beta 2 microglobulin (B2M) has been identified as a major component of amyloid deposits. This study was designed to determine whether changes occur in the synthesis of B2M in dialysis patients. Mononuclear cells (MNC) were isolated in peripheral blood from healthy volunteers, patients on hemodialysis (HD) and on continuous ambulatory peritoneal dialysis (CAPD). MNC were cultured in a medium of RPMI 1640 with or without interleukins IL-1, IL-2 or interferon INF-r. B2M in the cultured cells and supernatant was measured by enzyme immunoassay. IL-2 or INF-r stimulated B2M synthesis 'was significantly lower (25%) in patients on HD than in normal controls regardless of the type of dialysis membranes used, with no change in basal B2M synthesis. No differences were detected between healthy volunteers and CAPD patients. Preincubation of MNC with complement - activating or non-complement - activating membrane had no influence on B2M synthesis. The basal B2M synthesis of MNC significantly increased after a 4-hour HD regardless of the membranes used, and IL-2 and IFN-r stimulated synthesis were both essentially the same before and after HD. It was thus concluded that maximum capacity for B2M synthesis of MNC decreases in hemodialysis patients. This low responsiveness of MNC may be partially the cause for the reduction in cell-mediated immune response in HD patients.

Long-Term On-Line Hemodiafiltration Reduces Predialysis Beta-2-Microglobulin Levels in Chronic Hemodialysis Patients

2001 ◽  
Vol 19 (3) ◽  
pp. 301-307 ◽  
Author(s):  
Chun-Liang Lin ◽  
Chih-Wei Yang ◽  
Chin-Chen Chiang ◽  
Ching-Tung Chang ◽  
Chiu-Ching Huang
Keyword(s):  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
On Line ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Subcutaneous Amyloid-Tumor of Beta-2-Microglobulin Origin in a Long-Term Hemodialysis Patient

Nephron ◽  
1989 ◽  
Vol 53 (1) ◽  
pp. 73-75 ◽  
Author(s):  
J. Floege ◽  
A. Brandis ◽  
B. Nonnast-Daniel ◽  
M. Westhoff-Bleck ◽  
G. Tiedow ◽  
...  
Keyword(s):  
Hemodialysis Patient ◽  
Beta 2 ◽  
Beta 2 Microglobulin

scholarly journals Serum beta 2-microglobulin levels in asymptomatic HIV-1-infected subjects during long-term zidovudine treatment.

1991 ◽  
Vol 67 (3) ◽  
pp. 188-193 ◽  
Author(s):  
J W Mulder ◽  
P Krijnen ◽  
R A Coutinho ◽  
M Bakker ◽  
J Goudsmit ◽  
...  
Keyword(s):  
Zidovudine Treatment ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Hiv 1 ◽  
Asymptomatic Hiv

scholarly journals Pseudotumoral amyloidosis of beta 2-microglobulin origin in the buttock of a patient receiving long term haemodialysis.

1993 ◽  
Vol 46 (8) ◽  
pp. 771-772 ◽  
Author(s):  
J Fernandez-Alonso ◽  
C Rios-Camacho ◽  
A Valenzuela-Castano ◽  
J L Rocha-Castilla
Keyword(s):  
Beta 2 ◽  
Beta 2 Microglobulin
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