Loss of Glomerular Polyanion in vitro Induced by Mononuclear Blood Cells from Patients with Minimal-Change Nephrotic Syndrome

1986 ◽  
Vol 6 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Winston W. Bakker ◽  
Wilma H.J. van Luijk ◽  
Ronald J. Hené ◽  
Elizabeth M. Desmit ◽  
Gjalt K. van der Hem ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Blood Cells ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Glomerular Polyanion ◽  
Mononuclear Blood Cells

Cytochrome P-450 as a source of catalytic iron in minimal change nephrotic syndrome in rats

2001 ◽  
Vol 280 (1) ◽  
pp. F88-F94 ◽  
Author(s):  
Hua Liu ◽  
Sudhir V. Shah ◽  
Radhakrishna Baliga
Keyword(s):  
Nephrotic Syndrome ◽  
In Vitro Study ◽  
Minimal Change Nephrotic Syndrome ◽  
Significant Loss ◽  
Minimal Change ◽  
Puromycin Aminonucleoside ◽  
Glomerular Epithelial Cells ◽  
Cytochrome P 450 ◽  
Cyp Inhibitors

We have recently demonstrated an important pathogenic role for glomerular catalytic iron in the puromycin aminonucleoside (PAN) induced minimal change nephrotic syndrome (MCNS). The source of this iron capable of catalyzing free radical reactions is not known. We examined the role of cytochrome P-450 (CYP) as a source of catalytic iron in a model MCNS induced by single injection of PAN to rats. Treatment of PAN resulted in a marked increase in the catalytic iron associated with significant loss of glomerular CYP content. Administration of CYP inhibitors significantly prevented the injury-induced loss of CYP content and the increase in the catalytic iron in the glomeruli accompanied by a marked decrease in proteinuria. In an in vitro study utilizing glomerular epithelial cells (GEC), CYP inhibitors also markedly prevented the PAN-induced increase in the catalytic iron and hydroxyl radical formation accompanied by significant protection against PAN-induced cytotoxicity. Taken together our data indicate that the CYP, a group of heme protein, may serve as a significant source of this catalytic iron.

scholarly journals The beneficial effects of plasma exchange for treatment of acute kidney injury in minimal change nephrotic syndrome

2011 ◽  
Vol 45 (2) ◽  
pp. 179-185
Author(s):  
Hideyo Oguchi ◽  
Marohito Murakami ◽  
Takashi Araki ◽  
Mariko Meguro ◽  
Akinori Hashiguchi ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Nephrotic Syndrome ◽  
Plasma Exchange ◽  
Kidney Injury ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Beneficial Effects

scholarly journals Effect of single-dose rituximab on steroid-dependent minimal-change nephrotic syndrome in adults

2012 ◽  
Vol 28 (5) ◽  
pp. 1225-1232 ◽  
Author(s):  
T. Takei ◽  
M. Itabashi ◽  
T. Moriyama ◽  
C. Kojima ◽  
S. Shiohira ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Single Dose ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Steroid Dependent

LONG-TERM OUTCOME FOR CHILDREN WITH MINIMAL-CHANGE NEPHROTIC SYNDROME

The Lancet ◽  
1985 ◽  
Vol 325 (8425) ◽  
pp. 368-370 ◽  
Author(s):  
R.S. Trompeter ◽  
J. Hicks ◽  
B.W. Lloyd ◽  
R.H.R. White ◽  
J.S. Cameron
Keyword(s):  
Nephrotic Syndrome ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Role of ‘catalytic’ iron in an animal model of minimal change nephrotic syndrome

1996 ◽  
Vol 49 (2) ◽  
pp. 370-373 ◽  
Author(s):  
Norishi Ueda ◽  
Radhakrishna Baliga ◽  
Sudhir V. Shah
Keyword(s):  
Animal Model ◽  
Nephrotic Syndrome ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change
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