Expression of HLA-DR and Cytokine Genes on Interferon-γ-Stimulated Human Salivary Gland Cell Line

Pathobiology ◽  
1996 ◽  
Vol 64 (5) ◽  
pp. 255-261 ◽  
Author(s):  
Hironori Hamano ◽  
Norio Haneji ◽  
Kumiko Yanagi ◽  
Naozumi Ishimaru ◽  
Yoshio Hayashi
Keyword(s):  
Salivary Gland ◽  
Cell Line ◽  
Interferon Gamma ◽  
Gland Cell ◽  
Salivary Gland Cell ◽  
Cytokine Genes ◽  
Human Salivary Gland ◽  
Hla Dr

Interferon-γ induced cell death in a cultured human salivary gland cell line

1996 ◽  
Vol 167 (2) ◽  
pp. 297-304 ◽  
Author(s):  
Ava J. Wu ◽  
Zhi Jian Chen ◽  
Maria Tsokos ◽  
Brian C. O'Connell ◽  
Indu S. Ambudkar ◽  
...  
Keyword(s):  
Cell Death ◽  
Salivary Gland ◽  
Cell Line ◽  
Gland Cell ◽  
Interferon Γ ◽  
Salivary Gland Cell ◽  
Human Salivary Gland

Effect of tumor necrosis factor-? and interferon-? on the growth of a human salivary gland cell line

1994 ◽  
Vol 161 (2) ◽  
pp. 217-226 ◽  
Author(s):  
Ava J. Wu ◽  
Regina H. Kurrasch ◽  
Joseph Katz ◽  
Philip C. Fox ◽  
Bruce J. Baum ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Tumor Necrosis Factor ◽  
Cell Line ◽  
Tumor Necrosis ◽  
Gland Cell ◽  
Salivary Gland Cell ◽  
Human Salivary Gland ◽  
Necrosis Factor

scholarly journals Ca2+is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line

2015 ◽  
Vol 19 (3) ◽  
pp. 249
Author(s):  
Soonhong Park ◽  
Sang Kyun Ku ◽  
Hye Won Ji ◽  
Jong-Hoon Choi ◽  
Dong Min Shin
Keyword(s):  
Salivary Gland ◽  
Cell Line ◽  
Gland Cell ◽  
Salivary Gland Cell ◽  
Human Salivary Gland

scholarly journals RAGE expression and NF-κB activation attenuated by extracellular domain of RAGE in human salivary gland cell line

2009 ◽  
Vol 221 (2) ◽  
pp. 430-434 ◽  
Author(s):  
Christopher Chuong ◽  
Joseph Katz ◽  
Kaleb M. Pauley ◽  
Marievic Bulosan ◽  
Seunghee Cha
Keyword(s):  
Salivary Gland ◽  
Cell Line ◽  
Gland Cell ◽  
Extracellular Domain ◽  
Salivary Gland Cell ◽  
Human Salivary Gland ◽  
Rage Expression

Interferon-gamma induces persistent depletion of internal Ca2+ stores in a human salivary gland cell line

1996 ◽  
Vol 270 (2) ◽  
pp. C514-C521 ◽  
Author(s):  
A. J. Wu ◽  
Z. J. Chen ◽  
B. J. Baum ◽  
I. S. Ambudkar
Keyword(s):  
Cell Proliferation ◽  
Salivary Gland ◽  
Cell Line ◽  
Interferon Gamma ◽  
Prolonged Treatment ◽  
Tnf Alpha ◽  
Salivary Gland Cell ◽  
Ifn Gamma ◽  
Human Salivary Gland ◽  
In Cells

Interferon-gamma (IFN-gamma), in the presence of tumor necrosis factor-alpha (TNF-alpha), decreases proliferation of a human salivary gland ductal cell line, HSG (Wu, A., R. Kurrasch, J. Katz, P. Fox, B. Baum, and J. Atkinson. J. Cell. Physiol. 161:217-226, 1994). We examined the possible effects of these cytokines (1,000 U/ml IFN-gamma +/- 20 U/ml TNF-alpha for 7 days) on Ca2+ mobilization in HSG cells. In HSG cells, fetal bovine serum (10%) or carbachol (100 microM) stimulated rapid increases in cytosolic Ca2+ concentration ([Ca2+]i), apparently mobilized from different thapsigargin-sensitive intracellular Ca2+ stores. Serum induced a proliferative effect on HSG cells, which was suppressed (> 90%) by treatment with IFN-gamma +/- TNF-alpha, but not with TNF-alpha alone. Serum-, carbachol-, and thapsigargin-stimulated [Ca2+]i elevations were reduced by 90, 60, and > 65%, respectively, in cells treated with IFN-gamma +/- TNF-alpha and 30, 45, and 45%, respectively, in cells treated with TNF-alpha. Removal of the cytokines from the growth medium induced recovery of both cell proliferation and Ca2+ mobilization responses within 7 days. Treatment of HSG cells with thapsigargin (0.02-2 nM) induced a dose-dependent decrease in cell proliferation. Additionally, acute treatment (< 10 min) of cells with IFN-gamma did not affect [Ca2+]i or alter carbachol-, thapsigargin-, or serum-induced changes in [Ca2+]i. These data demonstrate that prolonged treatment of HSG cells with IFN-gamma +/- TNF-alpha leads to a persistent depletion of intracellular Ca2+ stores. We suggest that this may have a role in cell growth.

Modulation of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) by interferon-γ in a human salivary gland cell line

1997 ◽  
Vol 171 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Ava J. Wu ◽  
Robert M. Lafrenie ◽  
Chan Park ◽  
Wandee Apinhasmit ◽  
Zhi Jian Chen ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Line ◽  
Gland Cell ◽  
Interferon Γ ◽  
Salivary Gland Cell ◽  
Gelatinase A ◽  
Gelatinase B ◽  
Human Salivary Gland

Cytokines Modulate Interleukin-6 Production by Human Salivary Gland Cell Line

1994 ◽  
Vol 159 (2) ◽  
pp. 211-219 ◽  
Author(s):  
Joseph Katz ◽  
Rafi Nagler ◽  
Shlomo Barak ◽  
Avi Livneh ◽  
Bruce Baum ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Line ◽  
Interleukin 6 ◽  
Gland Cell ◽  
Salivary Gland Cell ◽  
Human Salivary Gland

Small Rho GTPases are important for acinus formation in a human salivary gland cell line

2006 ◽  
Vol 325 (3) ◽  
pp. 493-500 ◽  
Author(s):  
Virgínia O. Crema ◽  
Dânia E. Hamassaki ◽  
Marinilce F. Santos
Keyword(s):  
Salivary Gland ◽  
Cell Line ◽  
Rho Gtpases ◽  
Gland Cell ◽  
Salivary Gland Cell ◽  
Human Salivary Gland ◽  
Small Rho Gtpases
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