lnterleukin-8 and Tumor Necrosis Factor-Alpha Are Involved in Human Aortic Endothelial Cell Migration

Pathobiology ◽  
1994 ◽  
Vol 62 (3) ◽  
pp. 134-139 ◽  
Author(s):  
Zoltan Szekanecz ◽  
Manisha R. Shah ◽  
Lisa A. Harlow ◽  
William H. Pearce ◽  
Alisa E. Koch
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Endothelial Cell Migration ◽  
Human Aortic Endothelial Cell ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Anti-Atherosclerotic Effect of Hibiscus Leaf Polyphenols against Tumor Necrosis Factor-alpha-Induced Abnormal Vascular Smooth Muscle Cell Migration and Proliferation

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 620 ◽  
Author(s):  
Cheng-Chung Chou ◽  
Chi-Ping Wang ◽  
Jing-Hsien Chen ◽  
Hui-Hsuan Lin
Keyword(s):  
Smooth Muscle ◽  
Cell Migration ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

The proliferation and migration of vascular smooth muscle cells (VSMCs) are major events in the development of atherosclerosis following stimulation with proinflammatory cytokines, especially tumor necrosis factor-alpha (TNF-α). Plant-derived polyphenols have attracted considerable attention in the prevention of atherosclerosis. Hibiscus leaf has been showed to inhibit endothelial cell oxidative injury, low-density lipoprotein oxidation, and foam cell formation. In this study, we examined the anti-atherosclerotic effect of Hibiscus leaf polyphenols (HLPs) against abnormal VSMC migration and proliferation in vitro and in vivo. Firstly, VSMC A7r5 cells pretreated with TNF-α were demonstrated to trigger abnormal proliferation and affect matrix metalloproteinase (MMP) activities. Non-cytotoxic doses of HLPs abolished the TNF-α-induced MMP-9 expression and cell migration via inhibiting the protein kinase PKB (also known as Akt)/activator protein-1 (AP-1) pathway. On the other hand, HLP-mediated cell cycle G0/G1 arrest might be exerted by inducing the expressions of p53 and its downstream factors that, in turn, suppress cyclin E/cdk2 activity, preventing retinoblastoma (Rb) phosphorylation and the subsequent dissociation of Rb/E2F complex. HLPs also attenuated reactive oxygen species (ROS) production against TNF-α stimulation. In vivo, HLPs improved atherosclerotic lesions, and abnormal VSMC migration and proliferation. Our data present the first evidence of HLPs as an inhibitor of VSMC dysfunction, and provide a new mechanism for its anti-atherosclerotic activity.

HIGH LEVELS OF TUMOR NECROSIS FACTOR-ALPHA REDUCES PLACENTAL AQUAPORIN 3 EXPRESSION AND IMPAIRS in vitro TROPHOBLASTIC CELL MIGRATION

Placenta ◽  
2021 ◽  
Vol 112 ◽  
pp. e43
Author(s):  
Rinaldo Rodrigues dos Passos Junior ◽  
Raiany Alves Freitas ◽  
Julieta Reppetti ◽  
Yollyseth Medina ◽  
Vanessa Dela Justina ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Trophoblastic Cell ◽  
Necrosis Factor Alpha ◽  
Aquaporin 3 ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Suppression of endothelial cell activity by inhibition of tumor necrosis factor-alpha

2012 ◽  
Vol 14 (2) ◽  
pp. R88 ◽  
Author(s):  
Qiang Shu ◽  
Mohammad A Amin ◽  
Jeffrey H Ruth ◽  
Phillip L Campbell ◽  
Alisa E Koch
Keyword(s):  
Endothelial Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Cell Activity ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells

2014 ◽  
Vol 20 (47) ◽  
pp. 17863-17876 ◽  
Author(s):  
Atsushi Shiozaki ◽  
Hiroki Shimizu ◽  
Daisuke Ichikawa ◽  
Hirotaka Konishi ◽  
Shuhei Komatsu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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