Studies on the Toxicity and Binding Kinetics of Abrin in Normal and Epstein Barr Virus-Transformed Lymphocyte Culture-I: Experimental Results – 1

Pathobiology ◽  
1981 ◽  
Vol 49 (6) ◽  
pp. 306-318 ◽  
Author(s):  
Matthew Witten ◽  
Carol E. Bennett ◽  
Armand Glassman
Keyword(s):  
Epstein Barr Virus ◽  
Lymphocyte Culture ◽  
Experimental Results ◽  
Binding Kinetics ◽  
Barr Virus ◽  
Epstein Barr ◽  
Kinetics Of

scholarly journals Host factors associated with the kinetics of Epstein-Barr virus DNA load in patients with primary Epstein-Barr virus infection

2012 ◽  
Vol 56 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Hidetaka Nakai ◽  
Yoshiki Kawamura ◽  
Ken Sugata ◽  
Hiroko Sugiyama ◽  
Yoshihiko Enomoto ◽  
...  
Keyword(s):  
Virus Infection ◽  
Epstein Barr Virus ◽  
Host Factors ◽  
Epstein Barr Virus Infection ◽  
Factors Associated ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Kinetics Of

scholarly journals Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease

Blood ◽  
1994 ◽  
Vol 83 (9) ◽  
pp. 2715-2722 ◽  
Author(s):  
A Savoie ◽  
C Perpete ◽  
L Carpentier ◽  
J Joncas ◽  
C Alfieri
Keyword(s):  
Peripheral Blood ◽  
Epstein Barr Virus ◽  
Mononuclear Cells ◽  
Polymerase Chain Reaction Amplification ◽  
Lymphoproliferative Disease ◽  
Lymphocyte Culture ◽  
Barr Virus ◽  
Transplant Patients ◽  
Infected Cells ◽  
Epstein Barr

Abstract The Epstein-Barr virus (EBV) is known to cause posttransplant lymphoproliferative disease (PTLD) in immunosuppressed transplant patients. The results of this pilot study showed that all EBV- patients pretransplant experienced primary EBV infection within the first 3 months after transplant surgery. Virtually all of these patients had a higher burden of EBV-infected cells in their peripheral blood (PB) after infection by EBV than did the EBV+ pretransplant group when tested at the same intervals posttransplant. Salivary EBV titers also increased in most patients, but the difference between the two groups was statistically significant only at 12 months, whereupon EBV+ patients showed higher titers compared with EBV- (alpha < 0.053). Also, polymerase chain reaction amplification followed by Southern blotting was performed to detect EBV sequences in PB mononuclear cells. This technique allowed confirmation of the blood culture results and constituted a faster alternative compared with the culture assay. The highest increase in the number of EBV-infected lymphocytes at 3 months posttransplant obtained from PB was seen in a patient who developed fatal PTLD and in another with protracted infectious mononucleosis. Thus, the number of EBV-infected cells in PB was found to correlate positively with risk of development of PTLD at 3 months posttransplant in our group of pediatric transplant patients. This study showed that quantitative lymphocyte culture of PB was an accurate index of immunosuppression and a reliable method for assessing the risk of PTLD development.

scholarly journals Reactivation of lymphocryptovirus (Epstein–Barr virus chimpanzee) and dominance in chimpanzees

2010 ◽  
Vol 91 (8) ◽  
pp. 2049-2053 ◽  
Author(s):  
Rain Yamamoto ◽  
Migaku Teramoto ◽  
Ikuo Hayasaka ◽  
Koki Ikeda ◽  
Toshikazu Hasegawa ◽  
...  
Keyword(s):  
Viral Load ◽  
Epstein Barr Virus ◽  
Group Formation ◽  
Dominance Rank ◽  
Male Dominance ◽  
Barr Virus ◽  
Immunological Stress ◽  
Epstein Barr ◽  
Set Up ◽  
Kinetics Of

Nine male chimpanzees originally reared in solitary cages were set up to form a group. Plasma viral load of the lymphocryptovirus (LCV) of chimpanzee [Epstein–Barr virus chimpanzee (EBVcmp)] was measured by real-time PCR. In the group formation (Form) period, the first-ranking male showed an imminent increase in plasma EBVcmp load compared with 1 week before (pre-Form) and 3 months after (post-Form) group formation. Other upper-ranking males such as the second-, third- and fourth-male also showed the highest level of viral load in the Form period. The kinetics of EBVcmp load in the Form period were statistically different from other periods (against pre-Form, t=−4.878, P<0.001; against post-Form, t=6.434, P<0.001). The effect of the male dominance rank did not differ between the pre-Form and post-Form periods (t=−1.557, P=0.12). Reactivation of LCV (EBV) as an immunological stress marker for humans might also be applied to chimpanzees.

Kinetics of Epstein-Barr virus load and virus-specific CD8+ T cells in acute infectious mononucleosis

2011 ◽  
Vol 50 (3) ◽  
pp. 244-246 ◽  
Author(s):  
Yo Hoshino ◽  
Kazuo Nishikawa ◽  
Yoshinori Ito ◽  
Kiyotaka Kuzushima ◽  
Hiroshi Kimura
Keyword(s):  
T Cells ◽  
Infectious Mononucleosis ◽  
Cd8 T Cells ◽  
Epstein Barr Virus ◽  
Virus Load ◽  
Barr Virus ◽  
Epstein Barr ◽  
Acute Infectious Mononucleosis ◽  
Kinetics Of
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