Clonal Variation in the Impact of Ethyl Methanesulfonate and 5-Azacytidine on the Metastatic Phenotype of Human Prostatic Tumor Cells in Athymic Nude Mice

Pathobiology ◽  
1988 ◽  
Vol 56 (5) ◽  
pp. 270-276
Author(s):  
Joy L. Ware
Keyword(s):  
Tumor Cells ◽  
Nude Mice ◽  
Ethyl Methanesulfonate ◽  
Clonal Variation ◽  
Metastatic Phenotype ◽  
Athymic Nude Mice ◽  
Prostatic Tumor ◽  
The Impact

Establishment of Seven New Human Prostatic Tumor Lines in NMRI Athymic Nude Mice

1996 ◽  
pp. 49-51
Author(s):  
Wytske M. van Weerden ◽  
Gert J. van Steenbrugge ◽  
Cortina M. A. de Ridder ◽  
Johannes C. Romijn ◽  
Theodorus H. van der Kwast ◽  
...  
Keyword(s):  
Nude Mice ◽  
Athymic Nude Mice ◽  
Prostatic Tumor

Measurement of the survival of human tumor cells after implantation in athymic nude mice

1986 ◽  
Vol 38 (1) ◽  
pp. 97-101 ◽  
Author(s):  
J. C. Romijn ◽  
C. F. Verkoelen ◽  
F. H. Schroeder
Keyword(s):  
Tumor Cells ◽  
Nude Mice ◽  
Human Tumor ◽  
Human Tumor Cells ◽  
Athymic Nude Mice

scholarly journals Immunoselection of tumor cell variants by mice suppressed with ultraviolet radiation.

1982 ◽  
Vol 156 (4) ◽  
pp. 1025-1041 ◽  
Author(s):  
J L Urban ◽  
J M Holland ◽  
M L Kripke ◽  
H Schreiber
Keyword(s):  
Ultraviolet Radiation ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Nude Mice ◽  
Tumor Development ◽  
Phenotypic Change ◽  
Athymic Nude Mice ◽  
Induced Tumors ◽  
Progressive Growth ◽  
Parental Tumor

It has previously been shown that mice exposed to ultraviolet radiation (UV) fail to reject highly immunogenic UV-induced tumors, which are regularly rejected by normal mice. The present study shows, however, that this immunosuppresion is incomplete, as UV-treated mice can still mount certain tumor-specific immune responses and reject smaller inocula of tumor cells that regularly grow progressively in athymic nude mice. Furthermore, all tumor cell lines that were reisolated from the tumor mass resulting from one tumor passage through UV-treated recipients heritably lost a tumor-specific determinant present on the parental tumor cells used for transplantation, and a large percentage of these reisolated variant tumors had changed to progressively growing tumors, in that they were no longer rejected by normal mice. In contrast, none of the tumors reisolated from passage through athymic nude mice or anti-idiotypically suppressed mice showed this change in antigenicity and progressive growth behavior. Thus, it appears that the phenotypic change in tumors reisolated from UV-treated mice was caused by immunoselection, and that the tumor-specific immunity in these mice apparently restrained the outgrowth of the parental tumor cells despite the partial immunosuppression. Because of the regularity at which tumor variants arose in the UV-treated mice after tumor transplantation, it appears that the partial immunosuppression caused by UV-treatment may have favored the outgrowth of antigenic variants from the parental tumor cell population, possibly by allowing more time for the generation of tumor variants. A similar immunoselection process might be part of tumor progression during tumor development and preferentially occur in cancer-bearing individuals showing concomitant tumor immunity.

SURVIVAL OF HEMATOGENOUSLY DISSEMINATED ALLOGENEIC TUMOR CELLS IN ATHYMIC NUDE MICE

1976 ◽  
Vol 22 (2) ◽  
pp. 208-211 ◽  
Author(s):  
ISAIAH J. FIDLER ◽  
SHARON CAINES ◽  
ZOA DOLAN
Keyword(s):  
Tumor Cells ◽  
Nude Mice ◽  
Athymic Nude Mice ◽  
Allogeneic Tumor
Sign in / Sign up

Export Citation Format

Share Document