Dose-Dependent Effect of 17β-Estradiol Determined by Growth Curves and Flow Cytometric DNA Analysis of a Human Breast Carcinoma (T61) Grown in Nude Mice

Pathobiology ◽  
1985 ◽  
Vol 53 (4) ◽  
pp. 220-232 ◽  
Author(s):  
N. Brünner ◽  
M. Spang-Thomsen ◽  
L. Vindeløv ◽  
A. Nielsen ◽  
S.A. Engelholm ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Nude Mice ◽  
Dna Analysis ◽  
Growth Curves ◽  
Human Breast Carcinoma ◽  
Human Breast ◽  
Dependent Effect ◽  
Flow Cytometric ◽  
Dose Dependent ◽  
Dose Dependent Effect

Flow Cytometric DNA Analysis as Prognostic Factor in Human Breast Carcinoma

1993 ◽  
Vol 189 (4) ◽  
pp. 405-410 ◽  
Author(s):  
L. Ottestad ◽  
E.O. Pettersen ◽  
J.M. Nesland ◽  
E. Hannisdal ◽  
S.D. Fosså ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Breast Carcinoma ◽  
Dna Analysis ◽  
Human Breast Carcinoma ◽  
Human Breast ◽  
Flow Cytometric

beta-Carotene is Accumulated, Metabolized, and Possibly Converted to Retinol in Human Breast Carcinoma Cells (MCF-7)

2004 ◽  
Vol 74 (3) ◽  
pp. 171-177 ◽  
Author(s):  
Torres ◽  
Borojevic ◽  
Trugo
Keyword(s):  
Breast Carcinoma ◽  
Beta Carotene ◽  
Human Breast Carcinoma ◽  
Breast Carcinoma Cell Line ◽  
Human Breast ◽  
Cell Extracts ◽  
Human Breast Carcinoma Cells ◽  
Dose Dependent ◽  
Mcf 7 ◽  
In Cells

The aims of the present study were to investigate the uptake, accumulation, and metabolism of beta-carotene by the human breast carcinoma cell line MCF-7. Beta-carotene uptake was time- and dose-dependent, and independent of cell polarity. Beta-carotene accumulation in cells was linear as a function of its concentration in medium (1.3–4.1 mumol/L). It was accompanied by increasing amounts of retinol, which accumulated in cells following a sigmoid pattern, and by other four putative metabolites. Beta-apocarotenals, epoxides, endoperoxides, retinal, retinoic acid, and retinyl esters were not detected in cell extracts. Beta-carotene and its metabolites did not induce alterations in cell morphology or subcellular localization of epithelial mucins. Beta-carotene and retinol were released from cells that had previously accumulated beta-carotene, and were further incubated in beta-carotene- and retinol-free medium, but intracellular retinol content remained constant whereas b-carotene decreased. In conclusion, beta-carotene added to culture medium in physiological concentrations (1–6 mumol/L) is taken up and metabolized in MCF-7 cells, and is possibly converted to retinol.

Characterization of the T61 human breast carcinoma established in nude mice

1985 ◽  
Vol 21 (7) ◽  
pp. 833-843 ◽  
Author(s):  
N. Brünner ◽  
G.B. Bastert ◽  
H.S. Poulsen ◽  
M. Spang-Thomsen ◽  
S.A. Engelholm ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Nude Mice ◽  
Human Breast Carcinoma ◽  
Human Breast

Hormone-Independent Adenocarcinoma BX-1 Which Arose Spontaneously in Nude Mice Bearing Br-10, a Human Breast Carcinoma Strain

2015 ◽  
pp. 202-208
Author(s):  
Fumiki Asanuma ◽  
Yoshinori Yamada ◽  
Eiji Kawamura ◽  
Tetsuro Kubota ◽  
Shoichi Oka ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Nude Mice ◽  
Human Breast Carcinoma ◽  
Human Breast

Combined cytotoxic and endocrine therapy for human breast carcinoma (Br-10) serially transplanted into nude mice

1984 ◽  
Vol 14 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Tetsuro Kubota ◽  
Koichi Kubouchi ◽  
Jun-ichi Koh ◽  
Fumiki Asanuma ◽  
Koji Enomoto ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Endocrine Therapy ◽  
Nude Mice ◽  
Human Breast Carcinoma ◽  
Human Breast
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