Natural Cytotoxicity against Chemically Induced Neurogenic Rat Tumors

Pathobiology ◽  
1982 ◽  
Vol 50 (1) ◽  
pp. 39-55
Author(s):  
E. De Bernardo
Keyword(s):  
Natural Cytotoxicity ◽  
Chemically Induced ◽  
Rat Tumors

Biological and Surface Properties of C-Type Virus Particles Produced by Novikoff Ascites Hepatoma Cells

1977 ◽  
Vol 35 ◽  
pp. 388-389
Author(s):  
D.C. Hixson ◽  
J.C. Chan ◽  
J.M. Bowen ◽  
E.F. Walborg
Keyword(s):  
Surface Properties ◽  
Ricinus Communis ◽  
Rat Kidney ◽  
Leukemia Virus ◽  
Viral Envelope ◽  
Virus Particles ◽  
Chemically Induced ◽  
Sarcoma Virus ◽  
Hepatocarcinoma Cells ◽  
Type C

Several years ago Karasaki (1) reported the production of type C virus particles by Novikoff ascites hepatocarcinoma cells. More recently, Weinstein (2) has reported the presence of type C virus particles in cell cultures derived from transplantable and primary hepatocellular carcinomas. To date, the biological function of these virus and their significance in chemically induced hepatocarcinogenesis are unknown. The present studies were initiated to determine a possible role for type C virus particles in chemically induced hepatocarcinogenesis. This communication describes results of studies on the biological and surface properties of type C virus associated with Novikoff hepatocarcinoma cells.Ecotropic and xenotropic murine leukemia virus (MuLV) activity in ascitic fluid of Novikoff tumor-bearing rats was assayed in murine sarcoma virus transformed S+L- mouse cells and S+L- mink cells, respectively. The presence of sarcoma virus activity was assayed in non-virus-producing normal rat kidney (NRK) cells. Ferritin conjugates of concanavalin A (Fer-Con wheat germ agglutinin (Fer-WGA), and Ricinus communis agglutinins I and II (Fer-RCAI and Fer-RCAII) were used to probe the structure and topography of saccharide determinants present on the viral envelope.

Caspase-8 acts as a tumor suppressor in chemically induced hepatocarcinogenesis in mice

2014 ◽  
Vol 52 (01) ◽  
Author(s):  
HM Zimmermann ◽  
N Moro ◽  
R Sonntag ◽  
JM Bangen ◽  
YA Nevzorova ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Caspase 8 ◽  
Chemically Induced

Hepatic B cell leukemia-3 attenuates chemically-induced hepatocarcinogenesis in mice

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
N Gehrke ◽  
MA Wörns ◽  
Y Alt ◽  
A Waisman ◽  
N Hoevelmeyer ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Leukemia ◽  
Chemically Induced ◽  
B Cell Leukemia
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