Physiological Modulation of α-Adrenoceptor and 5HT Receptor Expression in Blood Vessels

1990 ◽  
Vol 27 (2-5) ◽  
pp. 146-152
Author(s):  
J.C. McGrath ◽  
W.R. Dunn ◽  
A.G.B. Templeton
Keyword(s):  
Blood Vessels ◽  
Receptor Expression ◽  
Alpha Adrenoceptor

Evidence for nonclassical alpha adrenoceptor blockade by prazosin in isolated rabbit blood vessels

Life Sciences ◽  
1980 ◽  
Vol 27 (23) ◽  
pp. 2187-2195 ◽  
Author(s):  
Ralph E. Purdy ◽  
Cynthia G. Krueger ◽  
Serena Young
Keyword(s):  
Blood Vessels ◽  
Alpha Adrenoceptor ◽  
Rabbit Blood

scholarly journals Changes in Hyaluronan Metabolism and RHAMM Receptor Expression Accompany Formation of Complicated Carotid Lesions and May be Pro-Angiogenic Mediators of Intimal Neovessel Growth

2007 ◽  
Vol 2 ◽  
pp. 117727190700200 ◽  
Author(s):  
Jerzy Krupinski ◽  
Priya Ethirajan ◽  
M. Angels Font ◽  
Marta Miguel Turu ◽  
John Gaffney ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Carotid Artery ◽  
Blood Vessels ◽  
Vascular Endothelium ◽  
Plaque Rupture ◽  
Receptor Expression ◽  
Post Mortem ◽  
Enzyme Expression ◽  
Atherosclerotic Lesions

Previous studies have shown that changes in expression of the glycosaminoglycan, hyaluronan (HA) were associated with erosion in areas of post-mortem coronary artery liable to rupture. Angiogenesis is an important feature of ulcerating haemorrhagic plaques prone to rupture. HA is a glycosaminoglycan known to possess potent angiogenic properties on metabolism to oligosaccharides of HA (o-HA) in the presence of hyaluronidase (HYAL) enzymes. In this study we have examined HA receptor and HYAL enzyme expression in a series of carotid artery specimens used as vascular transplants and exhibiting various stages of atherosclerotic lesions as determined by anatomo-pathology. Our results demonstrated dramatically increased expression of HYAL-1 in regions of inflammation associated with complicated plaques. Receptor for HA-mediated motility (RHAMM), which is known to be important in transducing angiogenic signals in vascular endothelium, was strongly expressed on intimal blood vessels from complicated lesions but almost absent from other regions including adventitial vessels. Metabolism of HA, together with up-regulation of RHAMM in complicated plaque lesions might be partly responsible for over-production of leaky neovessels and predisposition to plaque rupture.

Increased maternal cortisol in late-gestation ewes decreases fetal cardiac expression of 11β-HSD2 mRNA and the ratio of AT1 to AT2 receptor mRNA

2006 ◽  
Vol 291 (6) ◽  
pp. R1708-R1716 ◽  
Author(s):  
Seth A. Reini ◽  
Charles E. Wood ◽  
Ellen Jensen ◽  
Maureen Keller-Wood
Keyword(s):  
Blood Vessels ◽  
Renin Angiotensin System ◽  
Left Ventricular ◽  
Receptor Expression ◽  
Late Gestation ◽  
Angiotensin Receptors ◽  
Fetal Sheep ◽  
Igf Receptors ◽  
Adult Kidney ◽  
Cortisol Levels

Moderately elevated maternal cortisol levels late in gestation cause enlargement of the fetal sheep heart. We have used quantitative real-time PCR to examine expression of candidate genes in fetal hearts from mothers in whom cortisol levels were increased (by infusion of 1 mg cortisol·kg−1·day−1) or decreased (by adrenalectomy and replacement to 0.5 mg cortisol·kg−1·day−1) from 115 to 130 days gestation. Control ewes were not treated with steroid. Expression of mineralocorticoid receptor (MR), glucocorticoid receptor (GR), 11β-hydroxysteroid dehydrogenases 1 and 2 (11β-HSD1 and -2), IGF I and II, IGF receptors 1 and 2 (IGF-1R and IGF-2R), endothelial nitric oxide synthase, VEGF, myotrophin, angiotensinogen, the angiotensin receptors 1 and 2 (AT1R and AT2R), and the angiotensin converting enzymes 1 and 2 were measured. MR mRNA abundance in fetal hearts was found to be similar to that in adult kidney and hippocampus. Although there were no significant changes in most genes, 11β-HSD2 and IGF-1R expression were significantly decreased in the high cortisol group and 11β-HSD2 expression negatively correlated to left ventricular wall thickness. There was also a significant change in the ratio of AT receptor expression, with increased AT2R and decreased AT1R in the high cortisol group. MR, GR, and 11β-HSD1 immunoreactivity was found in cardiomyocytes and cardiac blood vessels in 126–128 day fetal sheep; in contrast 11β-HSD2 staining was predominantly in blood vessels. These results indicate that cortisol could indeed act in the fetal heart to induce enlargement and suggest that the renin-angiotensin system may play a role.

Effect of aging on alpha-adrenoceptor function in blood vessels

1990 ◽  
Vol 31 (3) ◽  
pp. 265
Author(s):  
Toshimasa Yamamoto ◽  
Kunio Shimazu ◽  
Naotoshi Tamura ◽  
Seietsu Watanaba ◽  
Atsuhiro Onoda ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Alpha Adrenoceptor

Cholinergic submandibular effects and muscarinic receptor expression in blood vessels of the rat

2008 ◽  
Vol 53 (7) ◽  
pp. 605-616 ◽  
Author(s):  
Anders T. Ryberg ◽  
Hanna Selberg ◽  
Ondrej Soukup ◽  
Kathryn Gradin ◽  
Gunnar Tobin
Keyword(s):  
Blood Vessels ◽  
Muscarinic Receptor ◽  
Receptor Expression

Effect of Temperature on Alpha-Adrenoceptor Affinity and Contractility of Rabbit Ear Blood Vessels

1989 ◽  
Vol 26 (4) ◽  
pp. 185-196 ◽  
Author(s):  
Michel F. Roberts ◽  
John D. Chilgren ◽  
Andrew C. Zygmunt
Keyword(s):  
Blood Vessels ◽  
Effect Of Temperature ◽  
Alpha Adrenoceptor ◽  
Rabbit Ear

Increased substance P receptor expression by blood vessels and lymphoid aggregates inClostridium difficile-induced pseudomembranous colitis

1996 ◽  
Vol 41 (3) ◽  
pp. 614-620 ◽  
Author(s):  
Christopher R. Mantyh ◽  
John E. Maggio ◽  
Patrick W. Mantyh ◽  
Steven R. Vigna ◽  
Theodore N. Pappas
Keyword(s):  
Substance P ◽  
Blood Vessels ◽  
Pseudomembranous Colitis ◽  
Receptor Expression ◽  
Substance P Receptor ◽  
Lymphoid Aggregates

Change in Morphology and Oxytocin Receptor Expression in the Uterine Blood Vessels during the Involution Process

2009 ◽  
Vol 67 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Tomoko Wakasa ◽  
Kenichi Wakasa ◽  
Masahiro Nakayama ◽  
Yuko Kuwae ◽  
Keiko Matsuoka ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Oxytocin Receptor ◽  
Receptor Expression
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