Cooling Augments Contractile Response to 5-Hydroxytryptamine via an Endothelium-Dependent Mechanism

1989 ◽  
Vol 26 (6) ◽  
pp. 347-359 ◽  
Author(s):  
M. Bodelsson ◽  
B. Arneklo-Nobin ◽  
K. Törnebrandt
Keyword(s):  
Contractile Response ◽  
Dependent Mechanism

A Calcium-Dependent Mechanism Responsible for Increasing the Freezing Tolerance of the Bivalve Mollusc Modiolus Demissus

1977 ◽  
Vol 69 (1) ◽  
pp. 13-21
Author(s):  
DENNIS J. MURPHY
Keyword(s):  
Low Temperature ◽  
Freezing Tolerance ◽  
Time Course ◽  
Cell Membranes ◽  
Contractile Response ◽  
Temperature Acclimation ◽  
Freezing Injury ◽  
Total Change ◽  
Calcium Dependent ◽  
Dependent Mechanism

1. A time course of the changes in blood Ca2+ and freezing tolerance of Modiolus demissus (Dillwyn) demonstrated that increases in freezing tolerance parallel increases in blood Ca2+. The increases in freezing tolerance occurred rapidly, suggesting that Ca2+ affects freezing tolerance directly by its presence in the blood. 2. The presence of La3+ reduced the freezing tolerance of isolated foot muscle. Thus, Ca2+ appears to increase freezing tolerance directly by binding to cell membranes. 3. The loss of the contractile response of freeze-thawed foot muscle to Ach, KCl and caffeine and the continued response to CaCl2 suggested that cell membranes are the primary sites of freezing injury. 4. The increase in blood Ca2+ following low-temperature acclimation accounted for only 40% of the total change in freezing tolerance. Therefore, other mechanisms responsible for increasing the freezing tolerance of M. demissus following low temperature acclimation also exist.

149: The Effect of Denervation on Signal Transduction Mechanisms of M2 and M3 Mediated Bladder Contractile Response

2005 ◽  
Vol 173 (4S) ◽  
pp. 40-40
Author(s):  
Leo R. Doumanian ◽  
Alan S. Braverman ◽  
Amitt S. Tibb ◽  
Michael R. Ruggieri
Keyword(s):  
Signal Transduction ◽  
Contractile Response ◽  
Transduction Mechanisms

Prostaglandin E2 does not attenuate adrenergic-induced cardiac contractile response

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
S. Pecha ◽  
E. Mudersbach ◽  
F.M. Wagner ◽  
Y. Alassar ◽  
S. Hakmi ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Contractile Response ◽  
Cardiac Contractile

Platelet Mobilization Induced by PAF and Its Role in the Thrombocytosis Triggered by Adrenaline in Rats

1989 ◽  
Vol 62 (04) ◽  
pp. 1107-1111 ◽  
Author(s):  
Hugo C Castro-Faria-Neto ◽  
Patricia T Bozza ◽  
Marco A Martins ◽  
Paulo M F L Dias ◽  
Patricia M R Silva ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Blood Samples ◽  
Platelet Counts ◽  
Platelet Number ◽  
Edta Solution ◽  
Web 2086 ◽  
Dependent Mechanism

SummaryThe injection of PAP (6 μg/kg, i. v.) induced, in rats, haemoconcentration accompanied by an increase in the platelet number, as attested by the counts of platelets in blood samples diluted in formalin-free EDTA solution. This increase was significant at 15 min, peaked from 1 to 4 h and returned to basal levels 24 h after the lipid administration. The release of platelets induced by PAP was inhibited dose-dependently by specific PAP receptor antagonists such as WEB 2086 (0.5-2 mg/kg), BN 52021 and 48740 RP (5-25 mg/kg). Furthermore, platelet mobilization was clearly impaired in splenectomized animals stimulated by PAP, whereas thrombocytopenia and haemoconcentration by the same stimulus were intact. It was also noted that a second injection of PAP, 24 h after the initial stimulation with the lipid, failed to induce an increase in platelet counts, indicating autodesensitization. Desensitization to PAP or pretreatment with PAP antagonists clearly prevented the increase in the platelet counts after stimulation by adrenaline (15 μg/kg). These findings suggest that, in rats, PAP can induce release of platelets by a spleen-dependent mechanism and that this lipid may be relevant to the thrombocytosis triggered by adrenaline.

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