Effects of Sodium Vanadate on Various Types of Vascular Smooth Muscles

1986 ◽  
Vol 23 (3) ◽  
pp. 113-124 ◽  
Author(s):  
Tomoko Shimada ◽  
Keiichi Shimamura ◽  
Satoru Sunano
Keyword(s):  
Smooth Muscles ◽  
Vascular Smooth Muscles ◽  
Sodium Vanadate

scholarly journals Modeling of the Bayliss‐Effect in Vascular Smooth Muscles

PAMM ◽  
2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Klemens Uhlmann ◽  
Daniel Balzani
Keyword(s):  
Smooth Muscles ◽  
Vascular Smooth Muscles ◽  
Bayliss Effect

Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery

2003 ◽  
Vol 284 (6) ◽  
pp. H2325-H2334 ◽  
Author(s):  
Tom Karkanis ◽  
Shaohua Li ◽  
J. Geoffrey Pickering ◽  
Stephen M. Sims
Keyword(s):  
Smooth Muscle ◽  
Current Density ◽  
Internal Thoracic Artery ◽  
Smooth Muscles ◽  
Vascular Smooth Muscles ◽  
Rt Pcr ◽  
Regulation Of Proliferation ◽  
Negative Membrane Potential ◽  
Inwardly Rectifying ◽  
Contractile Cells

Inwardly rectifying K+ (KIR) currents are present in some, but not all, vascular smooth muscles. We used patch-clamp methods to examine plasticity of this current by comparing contractile and proliferative phenotypes of a clonal human vascular smooth muscle cell line. Hyperpolarization of cells under voltage clamp elicited a large inward current that was selective for K+ and blocked by Ba2+. Current density was greater in proliferative compared with contractile cells (−4.5 ± 0.9 and −1.4 ± 0.3 pA/pF, respectively; P < 0.001). RT-PCR of mRNA from proliferative cells identified transcripts for Kir2.1 and Kir2.2 but not Kir2.3 potassium channels. Western blot analysis demonstrated greater expression of Kir2.1 protein in proliferative cells, consistent with the higher current density. Proliferative cells displayed a more negative membrane potential than contractile cells (−71 ± 2 and −35 ± 4 mV, respectively; P < 0.001). Ba2+ depolarized all cells, whereas small increases in extracellular K+ concentration elicited hyperpolarization only in contractile cells. Ba2+ inhibited [3H]thymidine incorporation, indicating a possible role for KIR channels in the regulation of proliferation. The phenotype-dependent plasticity of KIR channels may have relevance to vascular remodeling.

scholarly journals Hypercapnic Acidosis Activates K ATP Channels in Vascular Smooth Muscles

2003 ◽  
Vol 92 (11) ◽  
pp. 1225-1232 ◽  
Author(s):  
Xueren Wang ◽  
Jianping Wu ◽  
Li Li ◽  
Fuxue Chen ◽  
Runping Wang ◽  
...  
Keyword(s):  
Smooth Muscles ◽  
Hypercapnic Acidosis ◽  
Vascular Smooth Muscles

scholarly journals Rhythmic contraction generates adjustable passive stiffness in rabbit detrusor

2010 ◽  
Vol 108 (3) ◽  
pp. 544-553 ◽  
Author(s):  
Atheer M. Almasri ◽  
Paul H. Ratz ◽  
Hersch Bhatia ◽  
Adam P. Klausner ◽  
John E. Speich
Keyword(s):  
Kinase Inhibitor ◽  
Smooth Muscles ◽  
Physiological Role ◽  
Passive Tension ◽  
Passive Stiffness ◽  
Vascular Smooth Muscles ◽  
Rhythmic Contraction ◽  
Length Changes ◽  
Changes Over Time ◽  
Adjustable Passive Stiffness

The length-tension ( L-T) relationships in airway and vascular smooth muscles have been shown to adapt with length changes over time. Our prior studies have shown that the active and passive L-T relationships in rabbit detrusor smooth muscle (DSM) can adapt and that DSM exhibits adjustable passive stiffness (APS) characterized by a passive L-T curve that is a function of strain and activation history. The present study demonstrates that passive tension due to APS can represent a substantial fraction of total tension over a broad length range. Our previous studies have shown that maximal KCl-induced contractions at short muscle lengths generate APS that is revealed by increased pseudo-steady-state passive tension at longer lengths compared with previous measurements at those lengths. The objective of the present study was to determine the mechanisms involved in APS generation. Increasing the number of KCl-induced contractions or the duration of a contraction increased the amount of APS generated. Furthermore, a fraction of APS was restored in calcium-free solution and was sensitive to the general serine and threonine protein kinase inhibitor staurosporine. Most importantly, rhythmic contraction (RC) generated APS, and because RC occurs spontaneously in human bladder, a physiological role for RC was potentially identified.

Demonstration of an ectoATP-diphosphohydrolase (E.C.3.6.1.5.) in non-vascular smooth muscles of the bovine trachea

1994 ◽  
Vol 1200 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Maryse Picher ◽  
Richard Béliveau ◽  
Michel Potier ◽  
Diane Savaria ◽  
Éric Rousseau ◽  
...  
Keyword(s):  
Smooth Muscles ◽  
Vascular Smooth Muscles
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