Effect of Inhibition of Neuronal Uptake on the Flux of Extraluminal Noradrenaline into the Lumen of the Rat Tail Artery

1985 ◽  
Vol 22 (5) ◽  
pp. 244-246
Author(s):  
M.G. Venning ◽  
I.S. de la Lande
Keyword(s):  
Neuronal Uptake ◽  
Rat Tail Artery ◽  
Tail Artery ◽  
Rat Tail ◽  
Inhibition Of Neuronal Uptake

Release of 3,4-dihydroxyphenylglycol from the rat tail artery induced by veratridine

1984 ◽  
Vol 62 (1) ◽  
pp. 151-152 ◽  
Author(s):  
Vladimír Palatý
Keyword(s):  
Amperometric Detection ◽  
Neuronal Uptake ◽  
Rat Tail Artery ◽  
Free Solution ◽  
Release Of Noradrenaline ◽  
Tail Artery ◽  
Storage Vesicles ◽  
Rat Tail ◽  
Isolated Rat ◽  
External K

The overflow of endogenous 3,4-dihydroxyphenylethylene glycol and noradrenaline from the isolated rat tail artery was measured by high pressure liquid chromatography with amperometric detection. Veratridine, but not elevated external K, caused a significant increase in the overflow of the glycol under conditions when formation of the latter from released noradrenaline was prevented by blockade of neuronal uptake1 with desipramine. The results support the hypothesis that, in addition to evoking exocytotic release of noradrenaline into Ca-containing solution, the alkaloid also increases leakage of noradrenaline from storage vesicles. The latter process seems responsible for veratridine-induced release of noradrenaline into Ca2+-free solution.

Inactivation of Released Norepinephrine in Rat Tail Artery by Neuronal Uptake

1980 ◽  
Vol 2 (2) ◽  
pp. 121-132 ◽  
Author(s):  
R. Clinton Webb ◽  
Paul M. Vanhoutte ◽  
David F. Bohr
Keyword(s):  
Neuronal Uptake ◽  
Rat Tail Artery ◽  
Tail Artery ◽  
Rat Tail

Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes

2020 ◽  
Vol 182 ◽  
pp. 114263
Author(s):  
F. Fusi ◽  
P. Mugnai ◽  
A. Trezza ◽  
O. Spiga ◽  
G. Sgaragli
Keyword(s):  
Protein Kinases ◽  
Fine Tuning ◽  
Rat Tail Artery ◽  
Tail Artery ◽  
Channel Current ◽  
Cav1.2 Channel Current ◽  
Rat Tail

Neural control of reinnervated rat tail artery is restored despite incomplete perivascular plexus

2007 ◽  
Vol 135 (1-2) ◽  
pp. 130
Author(s):  
James A. Brock ◽  
Diana Tripovic ◽  
Svetlana Pianova ◽  
Elspeth M. McLachlan
Keyword(s):  
Neural Control ◽  
Rat Tail Artery ◽  
Tail Artery ◽  
Perivascular Plexus ◽  
Rat Tail

Ca2+-dependence of endothelin-1 induced contraction of rat tail artery

1991 ◽  
Vol 22 (2) ◽  
pp. 399-402 ◽  
Author(s):  
Xie-Nan Huang ◽  
Issei Takayanagi ◽  
Ryuichi Kurata ◽  
Tetsuhiro Hisayama
Keyword(s):  
Rat Tail Artery ◽  
Tail Artery ◽  
Endothelin 1 ◽  
Rat Tail

Calcium Efflux in Rat Tail Artery during Potassium Induced Relaxation

1980 ◽  
Vol 164 (3) ◽  
pp. 252-256 ◽  
Author(s):  
R. C. Webb ◽  
P. M. Vanhoutte ◽  
D. F. Bohr
Keyword(s):  
Rat Tail Artery ◽  
Calcium Efflux ◽  
Tail Artery ◽  
Rat Tail

scholarly journals VNUT and VMAT2 segregate within sympathetic varicosities and localize near preferred Cav2 isoforms in the rat tail artery

2019 ◽  
Vol 316 (1) ◽  
pp. H89-H105 ◽  
Author(s):  
Somayeh Mojard Kalkhoran ◽  
Sarah Heather Jane Chow ◽  
Jagdeep Singh Walia ◽  
Cynthia Gershome ◽  
Nickolas Saraev ◽  
...  
Keyword(s):  
Large Fraction ◽  
Atp Release ◽  
Sympathetic Nerves ◽  
Vesicular Monoamine Transporter ◽  
Rat Tail Artery ◽  
Monoamine Transporter ◽  
Vesicular Monoamine Transporter 2 ◽  
Tail Artery ◽  
Vesicle Pools ◽  
Rat Tail

ATP and norepinephrine (NE) are coreleased from peripheral sympathetic nerve terminals. Whether they are stored in the same vesicles has been debated for decades. Preferential dependence of NE or ATP release on Ca2+ influx through specific voltage-gated Ca2+ channel (Cav2) isoforms suggests that NE and ATP are stored in separate vesicle pools, but simultaneous imaging of NE and ATP containing vesicles within single varicosities has not been reported. We conducted an immunohistochemical study of vesicular monoamine transporter 2 (VMAT2/SLC18A2) and vesicular nucleotide translocase (VNUT/SLC17A9) as markers of vesicles containing NE and ATP in sympathetic nerves of the rat tail artery. A large fraction of varicosities exhibited neighboring, rather than overlapping, VNUT and VMAT2 fluorescent puncta. VMAT2, but not VNUT, colocalized with synaptotagmin 1. Cav2.1, Cav2.2, and Cav2.3 are expressed in nerves in the tunica adventitia. VMAT2 preferentially localized adjacent to Cav2.2 and Cav2.3 rather than Cav2.1. VNUT preferentially localized adjacent to Cav2.3 > Cav2.2 >> Cav2.1. With the use of wire myography, inhibition of field-stimulated vasoconstriction with the Cav2.3 blocker SNX-482 (0.25 µM) mimicked the effects of the P2X inhibitor suramin (100 µM) rather than the α-adrenergic inhibitor phentolamine (10 µM). Variable sensitivity to SNX-482 and suramin between animals closely correlated with Cav2.3 staining. We concluded that a majority of ATP and NE stores localize to separate vesicle pools that use different synaptotagmin isoforms and that localize near different Cav2 isoforms to mediate vesicle release. Cav2.3 appears to play a previously unrecognized role in mediating ATP release in the rat tail artery. NEW & NOTEWORTHY Immunofluorescence imaging of vesicular nucleotide translocase and vesicular monoamine transporter 2 in rat tail arteries revealed that ATP and norepinephrine, classical cotransmitters, localize to well-segregated vesicle pools. Furthermore, vesicular nucleotide translocase and vesicular monoamine transporter 2 exhibit preferential localization with specific Cav2 isoforms. These novel observations address long-standing debates regarding the mechanism(s) of sympathetic neurotransmitter corelease.

scholarly journals Influence of Mitochondrial Inhibition on Global and Local [Ca 2+ ] i in Rat Tail Artery

2002 ◽  
Vol 90 (7) ◽  
pp. 792-799 ◽  
Author(s):  
Karl Swärd ◽  
Karl Dreja ◽  
Anders Lindqvist ◽  
Erik Persson ◽  
Per Hellstrand
Keyword(s):  
Rat Tail Artery ◽  
Tail Artery ◽  
Global And Local ◽  
Rat Tail
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