Pharmacological Characterization of Alpha-Adrenergic Receptor Subtypes Mediating Contraction in Human Mesenteric Arteries and Veins

1985 ◽  
Vol 22 (4) ◽  
pp. 179-195 ◽  
Author(s):  
Kenneth Törnebrandt ◽  
Anders Nobin ◽  
Christer Owman
Keyword(s):  
Adrenergic Receptor ◽  
Mesenteric Arteries ◽  
Receptor Subtypes ◽  
Pharmacological Characterization ◽  
Alpha Adrenergic Receptor ◽  
Arteries And Veins

Molecular cloning and pharmacological characterization of three human alpha-2 adrenergic receptor subtypes

1990 ◽  
Vol 183 (3) ◽  
pp. 731-732
Author(s):  
R. Dijkema ◽  
J.H.G.M. Brands ◽  
J.H. Meyerink ◽  
P.G.J. Sanders ◽  
J.A.D.M. Tonnaer
Keyword(s):  
Molecular Cloning ◽  
Adrenergic Receptor ◽  
Receptor Subtypes ◽  
Pharmacological Characterization

Pharmacological Characterization of Postjunctional α-Adrenoceptors in Human Nasal Mucosa

2005 ◽  
Vol 19 (5) ◽  
pp. 495-502 ◽  
Author(s):  
Michel R. Corboz ◽  
Maria A. Rivelli ◽  
Lori Varty ◽  
Jennifer Mutter ◽  
Mark Cartwright ◽  
...  
Keyword(s):  
Nasal Mucosa ◽  
Isometric Force ◽  
Ringer Solution ◽  
Predominant Role ◽  
Pharmacological Characterization ◽  
Human Nasal Mucosa ◽  
Force Transducers ◽  
Arteries And Veins

Background Functional α1- and α2-adrenoreceptor subtype pharmacology was characterized in an in vitro human nasal mucosa contractile bioassay. Methods Nasal mucosa was obtained from 49 donor patients and mucosal strips were placed in chambers filled with Krebs–Ringer solution and attached to isometric force transducers. Results Nonselective α-adrenoreceptor agonists epinephrine, norepinephrine, and oxymetazoline produced concentration-dependent contractions of isolated human nasal mucosa (pD2= 5.2, 4.9, and 6.5, respectively). The α2-adrenoreceptor agonist BHT-920 (10 μM)–induced contractions were blocked by yohimbine (0.01–1 μM) and prazosin (0.01–1 μM) inhibited the contractile response to the α1-adrenoreceptor agonist phenylephrine (10 μM). Histological analysis showed that phenylephrine and BHT-920 differentially contracted the arteries and veins of human nasal mucosa, respectively. Conclusion Our results indicate that functional α1- and α2-adrenoceptors are present and functional in human nasal mucosa. The a 2-adrenoceptors display a predominant role in contracting the veins and the α1-adrenoceptors appear to preferentially constrict the human nasal arteries.

Pharmacological characterization of postjunctional α-adrenoceptors in isolated human omental arteries and veins

1984 ◽  
Vol 120 (1) ◽  
pp. 109-116 ◽  
Author(s):  
STIG STEEN ◽  
TOR V. C. SKÄRBY ◽  
LARS NORGREN ◽  
KARL-ERIK ANDERSSON
Keyword(s):  
Pharmacological Characterization ◽  
Arteries And Veins

Control of arteriovenous anastomoses in rabbit ear model of digital perfusion

1996 ◽  
Vol 271 (5) ◽  
pp. H2007-H2013
Author(s):  
D. C. Pollock ◽  
Z. Li ◽  
L. A. Koman ◽  
E. S. Gordon ◽  
T. L. Smith
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Subtypes ◽  
Arteriovenous Anastomoses ◽  
Cold Intolerance ◽  
Cutaneous Microcirculation ◽  
Rabbit Ear ◽  
New Zealand White Rabbits ◽  
Initial Characterization ◽  
Hands And Feet

The arteriovenous anastomoses (AVA) of the cutaneous microcirculation of the hands and feet are fundamental determinants of thermoregulatory blood flow and may be involved in cold intolerance. These direct microvascular studies are an initial characterization of adrenergic receptor subtypes participating in control of AVA in the ears of anesthetized male New Zealand White rabbits. Adrenergic alpha 1-stimulation with phenylephrine produced AVA constriction, whereas terazosin (an alpha 1-antagonist) produced dilation and attenuated the responses to phenylephrine. Adrenergic alpha 2-stimulation with UK-14304 produced constriction of the AVA, whereas atipamezole (an alpha 2-antagonist) produced dilation and attenuated the responses to UK-14304. When equimolar concentrations of antagonists were studied, the AVA dilation produced by alpha 2-blockade was greater than that produced by alpha 1-blockade. Norepinephrine (a mixed alpha 1- and alpha 2-agonist) also produced vasoconstriction, which was attenuated by both prazosin (an alpha 1-antagonist) and atipamezole. In summary, 1) AVA contain a heterogeneous mixture of both alpha 1- and alpha 2-receptors, and 2) alpha 2-receptors may have a greater influence than alpha 1-receptors on overall tone in AVA.

scholarly journals Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant.

Endocrinology ◽  
1996 ◽  
Vol 137 (6) ◽  
pp. 2638-2641 ◽  
Author(s):  
M R Candelore ◽  
L Deng ◽  
L M Tota ◽  
L J Kelly ◽  
M A Cascieri ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Pharmacological Characterization ◽  
Receptor Mutant

Alpha-Adrenergic Receptor Subtypes in the Cavernous Tissue of the Penis

1987 ◽  
Vol 137 (6) ◽  
Author(s):  
C.B. Dhabuwala ◽  
Jennifer Appleyard ◽  
Gordon F. Anderson
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Subtypes ◽  
Alpha Adrenergic Receptor ◽  
Cavernous Tissue
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