Doubling Time of Carcinoembryonic Antigen Is a Significant Prognostic Factor after the Surgical Resection of Locally Recurrent Rectal Cancer

2008 ◽  
Vol 25 (4) ◽  
pp. 319-324 ◽  
Author(s):  
Koji Tanaka ◽  
Shingo Noura ◽  
Masayuki Ohue ◽  
Yosuke Seki ◽  
Terumasa Yamada ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prognostic Factor ◽  
Carcinoembryonic Antigen ◽  
Surgical Resection ◽  
Doubling Time ◽  
Recurrent Rectal Cancer ◽  
Significant Prognostic Factor ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent

Usefulness of carcinoembryonic antigen doubling time in prognosis prediction after curative resection of locally recurrent rectal cancer: A retrospective study

2021 ◽  
Author(s):  
JUNICHI SAKAMOTO ◽  
Heita Ozawa ◽  
Hiroki Nakanishi ◽  
Shin Fujita
Keyword(s):  
Rectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Curative Resection ◽  
Doubling Time ◽  
Multivariate Analyses ◽  
Recurrent Rectal Cancer ◽  
Oncologic Outcomes ◽  
Prognosis Prediction ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent

Introduction: Given that doubling time is an indicator of tumor growth, we assessed the usefulness of carcinoembryonic antigen doubling time (CEA-DT) in prognosis prediction after curative resection for locally recurrent rectal cancer. Methods: During January 1986 to December 2016, 33 patients with locally recurrent rectal cancer who underwent curative resection at our hospital were retrospectively reviewed. The primary endpoint was the 3-year recurrence-free survival (RFS) rate. The Kaplan-Meier method was used to compare RFS rates and evaluate univariate and multivariate analyses for factors associated with oncologic outcomes, including CEA-DT. CEA-DT was classified into two groups: the short and long CEA-DT groups. Results: The 3-year overall survival and RFS rates were 62.6% and 42.4%, respectively. In multivariate analyses, CEA-DT was an independent risk factor for poor RFS. The 3-year RFS rate was significantly better in the long CEA-DT group than in the short CEA-DT group (58.8% vs. 25.0%, p = 0.0063). Conclusion: CEA-DT is a useful prognostic factor that can be assessed before surgery for locally recurrent rectal cancer. Long CEA-DT may indicate a favorable prognosis. Contrarily, short CEA-DT is associated with poor prognosis; therefore, further treatment intervention is necessary for patients with short CEA-DT.

Outcome of surgical resection of second-time locally recurrent rectal cancer

2012 ◽  
Vol 100 (3) ◽  
pp. 403-409 ◽  
Author(s):  
D. P. Harji ◽  
P. M. Sagar ◽  
K. Boyle ◽  
S. Maslekar ◽  
B. Griffiths ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Surgical Resection ◽  
Recurrent Rectal Cancer ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent

scholarly journals Intraoperative Electron Radiation Therapy (IOERT) in the management of locally recurrent rectal cancer

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Falk Roeder ◽  
Joerg-Michael Goetz ◽  
Gregor Habl ◽  
Marc Bischof ◽  
Robert Krempien ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Recurrent Rectal Cancer ◽  
Electron Radiation ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent

scholarly journals Advances in surgical management for locally recurrent rectal cancer: How far have we come?

2017 ◽  
Vol 23 (23) ◽  
pp. 4170 ◽  
Author(s):  
Daniel Jin-Keat Lee ◽  
Peter M Sagar ◽  
Gaitri Sadadcharam ◽  
Kok-Yang Tan
Keyword(s):  
Rectal Cancer ◽  
Surgical Management ◽  
Recurrent Rectal Cancer ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent
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